Lipid metabolism and disorders

LIPC-E97G Gain-of-function variant potentiates the hypocholesterolemic and anti-atherogenic effects of evinacumab in Ldlr-/- mice

This study shows that the LIPC-E97G variant enhances the cholesterol-lowering and anti-atherogenic effects of evinacumab in Ldlr-/- mice.

Genetic trans-effects link triglyceride-rich lipoproteins to blood pressure

The paper identifies genetic trans-effects linking triglyceride-rich lipoproteins to blood pressure using GWAS and protein expression data.

Functional characterization of hypertriglyceridemia-associated mutations in Lipase Maturation Factor 1 by a second-generation activity assay

This paper develops a new assay to functionally analyze LMF1 variants linked to hypertriglyceridemia, identifying 12 loss-of-function variants and highlighting Loop C as a critical region.

Dual Control of Low-Density Lipoprotein Cholesterol Levels by ANGPTL3 and ANGPTL8

This study investigates how ANGPTL3 and ANGPTL8 regulate LDL cholesterol levels through their cleavage products and interactions with lipases, showing that both proteins are required for maximal lipolysis inhibition.

Lipoprotein lipase requires a flexible lid and stable C-terminal, both maintained by ApoC-II peptide binding

This study uses molecular dynamics simulations and biochemical assays to show that ApoC-II peptide binding stabilizes LPL's structure and regulates its activity through lid flexibility and CTD flipping.

Impaired Chylomicron Secretion Results in Reduced Body Fat and Increased Intestinal Fatty Acid Oxidation by Activation of Autophagy

This study shows that DENND5B is critical for dietary triglyceride absorption and that its deletion reduces body fat and increases intestinal fatty acid oxidation via autophagy in both sexes.

Angiopoietin like protein 3 regulates low-density lipoprotein transport through aortic endothelial cells via endothelial lipase.

This study shows ANGPTL3 inhibits endothelial lipase-mediated LDL transport through aortic endothelial cells, which may explain mixed effects on ASCVD risk.

Endothelial CEPT1 Regulates Hepatic MTTP-Mediated Lipid Metabolism and Impacts Aortic Atherosclerosis

This study shows endothelial CEPT1 regulates hepatic MTTP activity, affecting lipid metabolism and aortic atherosclerosis.

CD300LG is a receptor for triglyceride-rich lipoproteins that facilitates postprandial lipid clearance

This study identifies CD300LG as a receptor for triglyceride-rich lipoproteins, showing its role in postprandial lipid clearance and linking it to cardiovascular disease risk.

Endothelial lipase facilitates low-density lipoprotein (LDL) uptake in LDL receptor deficiency by a heparan sulfate proteoglycan-dependent mechanism.

This study shows endothelial lipase (EL) enables LDL uptake in LDLR-deficient cells via heparan sulfate proteoglycans, highlighting a new pathway for LDL cholesterol reduction.

A Genetic Analysis of Lipid Metabolism Regulation in Han Chinese Youth in Xinjiang via Extreme Phenotypic Strategies

This study identifies potential lipid metabolism-related genes in Han Chinese youth from Xinjiang using extreme phenotypic selection and whole-exome sequencing.

ANGPTL3 binds to PCSK9 to coordinately regulate intracellular lipid homeostasis.

This study identifies a direct interaction between ANGPTL3 and PCSK9, showing they form a complex that regulates intracellular lipid homeostasis by modulating LDL uptake, degradation, and metabolism.

Lipoprotein distribution of Apo CIII glycoforms in healthy men is linked with low TG and increased insulin sensitivity

The paper measures Apo CIII proteoform distribution in lipoprotein fractions and finds two variants linked to lower triglycerides and improved insulin sensitivity.

RNA-binding protein A1CF modulates plasma triglyceride levels through posttranscriptional regulation of stress-induced VLDL secretion

This study identifies A1CF as a regulator of plasma triglycerides through posttranscriptional control of VLDL secretion and intracellular stress pathways.