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A comparison of continuous-wave fNIRS with quantitative fMRI-derived indices of brain function in the visual cortex

This study compares continuous-wave fNIRS with fMRI-derived indices in the visual cortex, finding strong cross-modal agreement and state-dependent relationships between haemoglobin modulations and fMRI signals.

Enhancing hypercompact Cas{Phi}2 activity through EPICA.2, an optimized eukaryotic directed evolution platform

The paper enhances Cas{Phi}2 activity using EPICA.2, an optimized directed evolution platform, resulting in evoCas{Phi}2 with 70-fold increased activity in human cells.

A cellular automaton model of osteogenic differentiation reveals identifiability limits of endpoint assays

This paper introduces a cellular automaton model to study osteogenic differentiation and shows endpoint assays have limited ability to distinguish underlying mechanisms.

Development of a PEGylated Parylene Nanopocket Membrane for the Capture and Release of Lipid Vesicles

This paper develops a PEGylated nanopocket membrane for size-selective capture and release of lipid vesicles and extracellular vesicles, demonstrating its effectiveness in separating particles of different sizes.

Controlled In Vitro Characterization of the Dynamic Response of Continuous Glucose Monitoring Systems: Adaptation of a Programmable Flow Platform and Decomposition of Dynamic Error

This paper develops a programmable flow platform to assess CGM systems' dynamic response and introduces metrics to decompose dynamic error into its components.

3D Hydrodynamic Flow Lithography

This paper introduces a 3D hydrodynamic flow lithography method to rapidly generate complex microstructures with tailored functionalities.

A platform for automated training of mammalian cell physiology

The paper introduces a platform called the Cell Trainer for automated training of mammalian cells using timed drug pulses and fluorescence imaging, demonstrating sensitization-like dynamics and feedback control in single-cell responses.

From Generation to Discrimination: Vision Foundation Models for Synthetic SEM Image Detection

This paper develops a deep learning framework to detect synthetic SEM images generated by GANs, using CLIP ViT-L-14 fine-tuned on real and synthetic datasets.

Human Osteochondral Granular Extracellular Matrix (gECM) Hydrogels Drive Tissue-Specific Composition and Mechanics

This study develops human-derived granular extracellular matrix hydrogels for osteochondral repair, showing distinct biochemical and mechanical properties between cartilage and bone gECM.

Dynamically actuated reconfigurable topographical surface enables active control of implant-associated infections

This paper introduces DARTS, a dynamic surface that kills and removes bacteria to control implant infections without antibiotics, showing effectiveness in a mouse model.

A universal plug-and-display vaccine platform for mucosal and systemic immunity using Bacillus subtilis membrane vesicles

This paper develops a universal vaccine platform using Bacillus subtilis membrane vesicles that elicit both systemic and mucosal immunity against Yersinia pestis.

A permeable protein nanocage enables facile cargo loading and cytosolic protein delivery

This paper introduces a permeable protein nanocage, QtEnc, enabling rapid and efficient cytosolic protein delivery through post-assembly cargo loading and pH-triggered release.

Multimodal profiling of proinflammatory protease activity identifies caspase-1 as a target for lung cancer interception

The paper identifies caspase-1 as a target for lung cancer interception by analyzing protease activity in a murine model and showing reduced tumor formation with combined IL-1b and caspase-1 inhibition.

A High-Throughput Platform for Rapid Adaptation of DNA Aptamers to SARS-CoV-2 Evolution

This paper develops a high-throughput platform to rapidly adapt DNA aptamers against evolving SARS-CoV-2 variants, identifying mutants with improved binding affinity and specificity.

Electrochemical Deformation of PEDOT:PSS Drives Mechanosensitive Cell Activation

This study shows that electrochemical deformation of PEDOT:PSS activates mechanosensitive pathways in HEK293T cells, revealing a mechanical component in conducting polymer-based interfaces.

Tuning viscoelasticity of dynamic covalent hydrogels for human tissue modeling

This study develops a tunable DCC hydrogel platform to control viscoelastic properties for 3D human tissue modeling.

MAE-UNETR++: Masked Autoencoder Pretraining for 3-D Lung Nodule Segmentation

This paper proposes MAE-UNETR++ for 3-D lung nodule segmentation, showing that MAE pretraining outperforms random initialization and Decathlon transfer learning in low-data scenarios.

Hydrophilic Polydopamine (hPDA) Fueled Bioglue Enhances Tissue Adhesion and Promotes Healing of Avascular Meniscus Tears

This paper introduces a hydrophilic polydopamine (hPDA) bioglue that enhances tissue adhesion and promotes healing of avascular meniscus tears by improving mechanical properties and tissue integration.

Development of Visually Indistinguishable Acoustic Coupling Pads for Double-Blind Focused Ultrasound Neuromodulation Studies

This paper develops and validates visually and mechanically indistinguishable acoustic coupling pads for double-blind tFUS studies, achieving precise control over ultrasound transmission and blocking.

Interpretable AI driven materiomics to decode microenvironmental cues for stem cell immunomodulation

This study uses AI to analyze hydrogel microenvironments and identifies matrix stiffness as key for enhancing MSC immunomodulation.