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Synonymous codon usage defines functional gene families

The paper defines functional gene families in S. cerevisiae by analyzing codon usage patterns using a new statistical method called ASCS.

Three Open Questions in Polygenic Score Portability

This paper investigates the portability of polygenic scores across genetic and demographic differences, identifying three key gaps in understanding.

Joint Modeling of Effect Sizes for Two Correlated Traits: Characterizing Trait Properties to Enhance Polygenic Risk Prediction

This study introduces PleioSDPR, a method that improves polygenic risk prediction by jointly modeling genetic effects across correlated traits, showing significant accuracy gains in real trait applications.

Global phylogeography of Amrasca biguttula (Hemiptera: Cicadellidae) across eight countries reveals a single-haplotype incursion into the United States beyond its putative native range

The paper analyzes genetic diversity of Amrasca biguttula across multiple regions to determine its native and invaded ranges and identify introduction patterns.

Proteomics profiles of growth-related proteins of Red Sokoto and West African Dwarf goats

This study compares plasma proteomic profiles of Red Sokoto and West African Dwarf goats to identify growth-related differences in protein expression and functional pathways.

A Sensitized ENU Mutagenesis Screen for Thrombosis Modifiers Identifies Suppressor Variants in Non-mutagenized Parental Generations Due to Antithrombotic Selective Pressures

The paper identifies four spontaneous mutations that confer survival in a thrombosis model by reducing platelet aggregation and altering gene expression.

Polyamine dysregulation converges with RASopathies on RAS/MAPK and sensory processing phenotypes in Drosophila

The paper identifies polyamine metabolism genes that converge with RASopathies on RAS/MAPK and sensory processing phenotypes in Drosophila.

Establishment of the Saudi Bank of Induced Pluripotent Stem Cells (SBiPSCs): A National Platform for iPSC-Based Research and Therapy

The paper establishes the Saudi Bank of Induced Pluripotent Stem Cells (SBiPSCs) to address underrepresentation of Middle Eastern populations in iPSC resources and supports immunocompatible cell therapies.

Genomic and pedigree-based approaches to predict parental breeding values for nut and kernel traits in almond (Prunus dulcis Mill. D. A. Webb)

This study uses genomic and pedigree-based methods to predict breeding values for nut and kernel traits in almond, finding that genomic methods provide slightly better predictions than pedigree-based methods.

The forbidden doubling: exploring rare spermatocyte polyploidy in mammals

The paper investigates rare polyploid spermatocytes in subterranean rodents, identifying unique meiotic features and potential checkpoint mechanisms.

CRISPR-mediated conditional mutagenesis of Smad1/5/8 reveals BMP/GDF signaling restricts postnatal bone overgrowth

This paper uses CRISPR-mediated conditional mutagenesis to show BMP/GDF signaling restricts postnatal bone overgrowth by regulating both periosteal and endosteal osteoblasts.

Targeting AKAP13 RhoGEF activity ameliorates pro-fibrotic phenotypes driven by the IPF associated AKAP13 risk variant

This study shows that an AKAP13 genetic variant promotes fibrosis by altering epithelial signaling, and inhibiting AKAP13's RhoGEF activity reduces fibrotic markers in IPF models.

Mismatch repair MLH complexes make distinct contributions to post-replicative mismatch repair versus trinucleotide repeat expansions

This study defines the hierarchy of MLH complex functions in Msh2-Msh3-mediated mismatch repair and trinucleotide repeat expansions in yeast.

Optimizing multi environment cowpea yield trial by appraising the fitness and similarities among test sites: a case study of IITA cowpea breeding program

This study evaluates the testing network of a cowpea breeding program by analyzing genotype-environment interactions and site similarities to optimize multi-environment yield trials.

Synaptic networks shape clinical phenotypes in neurodevelopmental disorders: An integrative clinical, genetic and biological perspective

This paper integrates genetic, synaptic, and developmental expression data to show how synaptic characteristics influence clinical phenotypes in neurodevelopmental disorders.

Systematic functional dissection of germline noncoding risk variants impacting clonal hematopoiesis

The paper identifies non-coding variants associated with clonal hematopoiesis and demonstrates their regulatory impact on gene expression and clonal expansion.

Mapping NMD-coupled alternative splicing in iPSC-derived brain cells: a resource for therapeutic discovery

The paper maps NMD-coupled alternative splicing events in iPSC-derived brain cells and identifies therapeutic targets for neurodevelopmental disorders.

Creating a new oilseed crop, pennycress, by combining key domestication traits using CRISPR genome editing

This paper uses CRISPR to edit pennycress, reducing glucosinolates and weediness to create a high-yield, low-carbon crop for agricultural and fuel use.

Genome-wide association study, network analysis, and reverse genetics pinpoint novel genes associated with seedling root growth variation of Arabidopsis thaliana under drought

This study identifies 68 genes associated with drought tolerance in Arabidopsis thaliana seedlings using GWAS and validates their roles through reverse genetics.

The MexMAGIC population reveals the genetic architecture of clinal trait variation in Mexican native maize

The paper uses a MAGIC population to study genetic architecture of clinal traits in Mexican maize, finding one major QTL for tassel branching and multiple QTL for flowering time with complex environmental associations.