A. Thomas

SATB2 induction of a neural crest mesenchyme-like program drives invasion and drug resistance in melanoma

This study shows SATB2 drives melanoma invasion and drug resistance by inducing a neural crest mesenchyme-like transcriptional program in zebrafish and human models.

Magnitude and kinetics of T cell and antibody responses during H1N1pdm09 infection in outbred and inbred Babraham pigs

This study compares T cell and antibody responses to H1N1pdm09 infection in inbred and outbred pigs, showing similar immune responses despite differences in genetic background.

Peripheral microtubules ensure asymmetric furrow positioning in neural stem cells

The paper shows that peripheral microtubules and the Chromosome Passenger Complex are required for cortical centralspindlin recruitment, which ensures asymmetric furrow positioning in neural stem cells.

HIV-specific T-cell responses reflect substantive in vivo interactions with infected cells despite long-term therapy

The paper shows HIV-specific T-cell responses persist despite long-term ART, indicating ongoing recognition of infected cells and suggesting the reservoir is not fully immunologically silent.

A small molecule screen identified N-Acetyl-L-cysteine for promoting ex vivo growth of single circulating tumor cells

The paper identifies N-acetylcysteine (NAC) as a compound that promotes ex vivo growth of single circulating tumor cells by reducing oxidative stress.

Scoping reviews in medical education: A scoping review

This study analyzes scoping reviews in medical education journals to identify gaps in their conduct and reporting.

Activation of bone marrow adaptive immunity in type 2 diabetes: rescue by co-stimulation modulator Abatacept

This paper investigates adaptive immune activation in bone marrow of T2D patients and mice, showing that Abatacept reduces T cell activation and improves cardiac function.

A metabolic CRISPR-Cas9 screen in Chinese hamster ovary cells identifies glutamine-sensitive genes

The paper uses a CRISPR-Cas9 screen in Chinese hamster ovary cells to identify glutamine-sensitive genes, revealing a novel lipase involved in TCA cycle regulation.

SCLC_CellMiner: Integrated Genomics and Therapeutics Predictors of Small Cell Lung Cancer Cell Lines based on their genomic signatures

SCLC_CellMiner provides an integrated resource of 118 SCLC cell lines with omics data and drug sensitivity, identifying molecular subtypes and therapeutic targets.

High laboratory mouse pre-weaning mortality associated with litter overlap, advanced mother age, small and large litters

This study identifies risk factors for high pre-weaning mortality in laboratory mice, finding that litter overlap, advanced mother age, and extreme litter sizes increase pup death rates.

Longitudinal whole-exome sequencing of cell-free DNA unravels the metastatic evolutionary dynamics of BRCA2 mutated breast cancer

This study uses longitudinal whole-exome sequencing of cell-free DNA to track the evolutionary dynamics of BRCA2-mutated breast cancer over 12 years, identifying key mutations and immune escape mechanisms.

Diet-induced loss of adipose Hexokinase 2 triggers hyperglycemia

The paper shows that loss of Hexokinase 2 in adipose tissue due to high fat diet leads to hyperglycemia through systemic glucose homeostasis disruption.

Oligomeric state of the ZIKV E protein defines protective immune responses.

This study shows that dimeric Zika E protein antigens induce stronger neutralizing antibodies than monomers, suggesting that mimicking viral quaternary structure improves subunit vaccine efficacy.

Clades of huge phage from across Earth’s ecosystems

The paper identifies major clades of large phage genomes across diverse ecosystems and highlights their expanded genetic repertoires and potential functional roles.

Crowdsourced MRI quality metrics and expert quality annotations for training of humans and machines

The paper introduces MRIQC Web-API, a crowdsourced database for MRI quality metrics and expert annotations to train humans and machines in image quality assessment.

Neuroendocrine negative SCLC is mostly RB1 WT and may be sensitive to CDK4/6 inhibition

The paper identifies RB1 WT SCLC cell lines and finds some are sensitive to CDK4/6 inhibition.

Integrated proteogenomic analysis of metastatic thoracic tumors identifies APOBEC mutagenesis and copy number alterations as drivers of proteogenomic tumor evolution and heterogeneity