J. Huang

This study shows that progestin receptors regulate coagulation factors during ovulation in zebrafish, linking blood clotting to the ovulation process.

The paper identifies IgA-secreting AT2-like cells in fibrotic lungs and shows their role in ECM IgA deposition through spatial transcriptomics and scRNA-seq.

The paper investigates paradoxical activation of RAF kinases, showing that 14-3-3 proteins enhance this effect by stabilizing RAF conformations and dimerization.

This study identifies physiochemical features of TCRs that influence dissociation kinetics using SMD and machine learning, showing hydrogen bonds in specific regions are critical for bond lifetime and immunogenicity.

This study identifies PLATZ4's role in enhancing drought tolerance and ABA sensitivity in Arabidopsis by suppressing PIP2;8 and upregulating stress-related genes through interaction with AITR6.

This paper develops a lung-selective Cas13d-based nanotherapy targeting Ctsl to inhibit SARS-CoV-2 infection, showing improved survival and reduced viral burden in mice.

This study identifies molecular aberrations in normal breast tissue from high-risk women, linking epigenetic and transcriptional changes to breast cancer susceptibility.

The paper investigates DNA repair mechanisms after CRISPR-Cas12a-induced double-strand breaks in Magnaporthe oryzae, identifying locus-dependent and error-prone repair pathways leading to various mutation types.

This study shows Yersinia enterocolitica modulates histone modifications in human macrophages to alter gene expression related to immune response and metabolism.

The paper identifies three new folds in the solute carrier superfamily, with one validated experimentally in the SLC44 family, providing insights into structure-function relationships.

This study identifies 17 FDA-approved compounds with antiviral efficacy against SARS-CoV-2 using high-throughput screening and finds lactoferrin as a promising drug candidate with multiple antiviral mechanisms.

This study uses iTRAQ-based proteomics to identify cold stress-responsive proteins in japonica rice seedlings, finding 289 regulated proteins involved in photosynthesis and metabolism.

This study examines how Salmonella develops resistance to enrofloxacin under varying sub-inhibitory concentrations, identifying gene expression changes and mutations involved in resistance.

The paper identifies two circRNAs whose m6A methylation synergistically promotes pulmonary fibrosis by targeting eIF4A3, mediated by METTL3.

This study uses recombinant Lloviu virus to investigate replication mechanisms and host interactions of an uncultured filovirus related to Ebola.

This study uses iPSC-derived airway cells to model SARS-CoV-2 infection, showing multiciliated cells as primary targets and demonstrating antiviral responses to remdesivir and camostat methylate.

This study identifies 187 DNA/RNA differences in 36 wheat genes associated with Fusarium head blight, showing their role in regulating FHB response through structural changes and miRNA interactions.

This study examines antibody responses to SARS-CoV-2 mRNA vaccines in naive and previously infected individuals, finding robust IgG and varying neutralizing antibody levels against different variants.

This study investigates how two first-generation MsbA inhibitors, TBT1 and G247, induce opposite allosteric effects by binding to distinct sites in the transmembrane domains.

The paper shows that CRISPR-Cas13 can reduce RNA in plants without the Cas13 protein, using a mechanism similar to RNAi.

This study determines the structure of post-fusion hMPV B2 F protein, assesses its receptor binding and immunogenicity, and shows it induces neutralizing antibodies against multiple hMPV strains.

The paper shows lung epithelial cells can produce TD-Ag-specific antibodies, dependent on CD4+ T cells, challenging the notion that B cells are the sole source of such antibodies.

This paper identifies PRC2-mediated epigenetic repression as critical for regulating gene expression during biotrophic growth in M. oryzae, with Pmk1 coordinating this process by modulating Suz12.

This study identifies three ultrapotent SARS-CoV-2 neutralizing antibodies effective against B.1.351 variants, showing synergistic effects and protective efficacy in mice.

The paper identifies simeprevir as a potent inhibitor of SARS-CoV-2 replication that synergizes with remdesivir in vitro.

This study evaluates the impact of phase resolution strategies on phylogenomic analyses under the multispecies coalescent model, finding that random phasing leads to biased parameter estimates.

This paper investigates cytostatic hypothermia as a therapeutic approach for glioblastoma, showing it extends survival in rodent models by halting tumor growth without chemical interventions.

This study shows that combining anti-GD2 and anti-CD47 antibodies enhances anti-tumor responses by recruiting macrophages and disrupting the GD2:Siglec-7 interaction in GD2+ cancers.

The paper observes actomyosin contractile instability in isolated cytokinetic rings and shows myosin II turnover prevents catastrophic aggregation and fracture.

This study shows SUMOylation of GMFB increases its stability and trans-localization, upregulating inflammatory pathways in RPE cells under oxidative stress and inflammation.