J. Zheng

This study identifies and characterizes Aeromonas species in farmed loaches from China, finding high prevalence of A. veronii and resistance to multiple antibiotics.

This study identifies SNP markers associated with salt tolerance traits in upland cotton through genome-wide association analysis.

The paper uses statistical coupling analysis to study sensor-effector organization in TRP and Kv ion channels, identifying conserved core sectors and family-specific accessory sectors with three localization principles.

This study investigates a weak mode of bacterial adhesion by applying an electric field to pilus-less Caulobacter crescentus mutants, revealing transient 'quasi-attachment' behavior.

This study investigates cell-type apoptosis in lung tissues during SARS-CoV-2 infection, finding both intrinsic and extrinsic apoptotic pathways are activated, while some cell types remain refractory to infection.

This study identifies the PLA2G2D-PGD2/DP1 pathway as a therapeutic target for severe COVID-19 in middle-aged mice, showing protection through DP1 antagonism.

The paper defines and extends the near-infrared biological window for improved in vivo fluorescence imaging, proposing new regions and demonstrating enhanced imaging capabilities.

This study identifies molecular interfaces that mediate EphA2 receptor assembly and distinguishes between canonical and noncanonical signaling pathways.

This study analyzes Salmonella contamination in pistachios using genomic data to identify persistent strains and their adaptation mechanisms.

This study determines the crystal structures of DRH-3 domains bound to RNA, revealing structural features that explain its role in RNAi and evolutionary divergence from Dicer-like helicases.

This study shows that high oxygen tension upregulates integrin α6 in nucleus pulposus cells, which protects against intervertebral disc degeneration by reducing apoptosis and oxidative stress.

This study uses AIE dots for non-invasive NIR-IIb fluorescence hysterography to visualize uterine structures and function in mice without impairing reproductive capacity.

This study shows that post-infection treatment with a deuterated protease inhibitor improves survival and reduces viral load in mice infected with SARS-CoV-2.

The paper uses synthetic TAL effectors delivered by bacteria to activate the maize gene gl3, revealing its role in cuticular wax biosynthesis and identifying downstream genes involved in this process.

This study identifies genetic factors enabling Exiguobacterium's cosmopolitan distribution through comparative genomics and metabolic analysis of 103 strains.

This study identifies a regulatory pathway involving CPEB2 m6A methylation that affects BTB permeability through SRSF5 and P51-ETS1, enhancing drug efficacy in glioma treatment.

This paper develops a potent, low-cost nanobody therapeutic, Nanosota-1C-Fc, that effectively blocks SARS-CoV-2 infection in vitro and in vivo with high affinity and stability.

This study identifies an unconventional voltage-sensing mechanism in TRPV1 channels where outer pore acidic residues, not the S4 segment, mediate voltage sensitivity and activation.

This study investigates how different doses of glycerol monolaurate (GML) affect gut microbiota and metabolic syndrome in low-fat diet-fed mice, showing high-dose GML reduces MetS through microbiota changes.

The paper identifies lanthipeptide synthetases as key enzymes in the biosynthesis of 2-aminovinyl-cysteine motifs in thioamitides, revealing their role in dehydration and macrocyclization.

This study develops a recombinant SARS-CoV-2 RBD molecule fused with a T helper epitope as an adjuvant, showing strong neutralizing antibody response in mice.

This study combines proteomics and Mendelian randomization to identify aspirin-targeted proteins associated with reduced colorectal cancer risk.

This study uses K18-hACE2 mice to demonstrate severe SARS-CoV-2 infection in lungs and brains, thrombosis in severe cases, and the protective effect of convalescent plasma against lethal disease, while showing anosmia occurs independently of clinical outcome.

The paper investigates whether pre-existing cutaneous conditions increase SARS-CoV-2 infection risk by examining ACE2 expression and skin barrier function in human and mouse models.

The paper estimates the germline mutation rate in rhesus macaques and finds paternal age correlation, male contribution dominance, and divergence time implications for primate phylogeny.

This study identifies and characterizes the CdrSL gene regulatory network in archaea, showing its role in regulating cell division through transcriptional control of FtsZ2.

The paper uses scRNA-seq to compare ACE2 expression and bladder cell clusters in OAB and healthy mice, finding reduced umbrella cells and higher ACE2 in epithelial cells, suggesting altered 2019-nCoV infection pathways.

The paper investigates the host range of SARS-CoV-2 and related coronaviruses and identifies an improved ACE2-Fc variant effective against both SARS-CoV-2 and SARS-CoV-1.

This study identifies non-steroid soluble factors released by CNS cancers and injuries that cause systemic immunosuppression by inducing thymic and splenic involution and reducing MHC class II expression.

This study shows artesunate interacts with the vitamin D receptor to reverse sepsis-induced immunosuppression by enhancing autophagy and modulating NF-κB activity.