S. Singh

This study shows YAP1 is essential for bile duct development and reveals hepatocyte adaptation in its absence.

This study identifies the EphB2-MYC axis as a key driver of Barrett's Esophagus progression to esophageal adenocarcinoma and a potential therapeutic target.

This study evaluates the replication, antibody sensitivity, and vaccine efficacy of the SARS-CoV-2 B.1.617.2 Delta variant compared to other variants and vaccine-elicited immunity.

This paper develops a 3-D vascularized breast cancer model to study osteoblast influence on tumor progression and identifies gene expression changes associated with pre-metastatic niche formation.

This study evaluates the efficacy of three herbicides against Rumex spp. in wheat, finding that carfentrazone + metsulfuron provides 70-90% control at double the recommended dose.

The paper identifies nine promoter-variant strains of HIV-1C in Indian patients, showing genetic diversity in transcription factor binding sites that may affect viral latency and reservoir characteristics.

The paper investigates how a cryptic pocket in β-lactamase, formed under the Ω-loop, enhances enzyme activity against penicillin, suggesting excited states can improve function.

This study identifies molecular interfaces that mediate EphA2 receptor assembly and distinguishes between canonical and noncanonical signaling pathways.

The paper analyzes monoclonal antibodies from vaccinated non-human primates to identify a conserved immunodominant epitope in HIV-1 Env and how different lineages target it for potent neutralization.

The paper examines the antibody response to SARS-CoV-2 mRNA vaccines in pregnant women and their neonates, highlighting the need for further study on vaccine immunology during pregnancy.

This paper shows that combining MEK and STAT3 inhibitors reprograms stromal inflammation and enhances immunotherapy response in pancreatic cancer.

The paper investigates how loss of GGTA1 function in primates affects host-microbiota interactions, finding that it reduces microbiota pathogenicity through IgA targeting of Gal-expressing bacteria.

The paper identifies recurrent transcriptional regulatory heterogeneities in early-stage luminal breast cancer using stochastic profiling and 10-cell RNA sequencing, revealing genes associated with EMT and pan-cancer drivers.

This study identifies replication stress in premalignant OPCs before glioma formation using stochastic profiling in a mouse model.

This study identifies single domain antibodies that neutralize SARS-CoV2 by targeting the cleavage site and receptor binding domain of the spike protein, showing their stability and effectiveness in blocking infectivity.

This paper identifies mucoricin, a ricin-like toxin produced by Mucorales fungi, critical for mucormycosis pathogenesis and a potential therapeutic target.

This study repositions Alisporivir, an anti-Hepatitis C drug, as a potential treatment for artemisinin-resistant malaria by targeting PfCyP-19B, which is overexpressed in resistant parasites.

This study identifies metabolic reprogramming in ibrutinib-resistant DLBCL using multi-omics integration, revealing the BTK-PI3K-AKT-IL4I1 axis as a key driver of drug resistance.

This study evaluates the antimalarial effect of Prasugrel, an FDA-approved purinergic receptor antagonist, on Plasmodium falciparum by targeting PfSR12, a putative purinergic receptor.

This study examines nAb responses in an infant with interclade HIV-1 superinfection, finding that neutralizing antibodies primarily target the superinfecting strain and depend on glycans.

This paper investigates how Nsp10 activates Nsp16 and identifies a cryptic pocket in SARS-CoV-2 Nsp16 that could be targeted for pan-coronavirus antivirals.

This study shows that HIV-1 broadly neutralizing antibodies and plasma from HIV-1 infected children can cross-neutralize SARS-CoV-2 by targeting conserved epitopes and glycans on the spike protein.

The paper identifies a NOTCH-YAP1/TEAD-DNMT1 axis that drives hepatocyte reprogramming into intrahepatic cholangiocarcinoma and reveals its role in tumor development.

This study identifies a single sulfatase essential for colonic mucin O-glycan metabolism and intestinal colonization by Bacteroides thetaiotaomicron.

This study evaluates the protective efficacy of a CRISPR-edited Leishmania major strain against visceral leishmaniasis in hamsters and shows it induces a pro-inflammatory immune response and prevents disease.

This study shows the bone microenvironment enhances metastatic potential of cancer cells, enabling further dissemination and multi-organ metastasis, independent of genetic selection.

The paper shows that the bone microenvironment induces endocrine resistance in ER+ breast cancer metastases through epigenomic reprogramming mediated by EZH2.

This study identifies GAK and PRKCD as positive regulators of PRKN-independent mitophagy through genetic screening and functional analysis in vitro and in vivo.

This study establishes a mouse model to investigate PPRV pathogenesis, showing that IFNR KO mice succumb to infection regardless of dose, with neutrophils/macrophages transporting virus to CNS and CD8+ T cells providing protection.