Vilas Menon

The paper investigates how Th17 cytokines influence microglial and blood-brain barrier responses during post-infectious encephalitis using single-cell RNA sequencing and spatial transcriptomics.

This study shows that INPP5D/SHIP1 regulates inflammasome activation in human microglia, with reduced INPP5D leading to increased IL-1β and IL-18 secretion.

This study shows that SORL1 loss reduces APOE levels specifically in neurons and astrocytes, linking SORL1 and APOE to Alzheimer's disease risk through distinct pathways.

This paper presents a cellular taxonomy of the adult human spinal cord using single nucleus RNA-sequencing and spatial transcriptomics, identifying 29 glial and 35 neuronal clusters and highlighting motoneuron vulnerability to ALS.

This study identifies St18 as a transcriptional determinant specifying projection neuron identity in the MGE lineage and shows its role in regulating migration and morphology of GPe neurons.

The paper identifies cell-type and cell-subtype specific eQTLs in aging human cortex, revealing variant effects on gene expression and disease associations.

This study uses snRNAseq to analyze HD mouse models and human brain tissue, identifying impaired oligodendrocyte maturation and a potential role for thiamine metabolism in disease pathology.

The paper identifies somatostatin and intra-telencephalic neurons as significantly associated with Alzheimer's disease using bulk and single-nucleus transcriptomics across multiple datasets.

This study identifies disease-enriched microglial subsets and validates compounds that modulate their states using single-cell RNA sequencing and in vitro experiments.

The paper identifies a cell-type specific signature of cognitive resilience to Alzheimer's disease in human and mouse models, highlighting excitatory intratelencephalic cortical neurons and several resilience genes.

The paper compares TDP-43's transcriptional and splicing effects in muscle and neuronal cells, showing tissue-specific roles in disease.

The paper uses single-cell RNA-seq to analyze relay neurons in the dLGN across species, finding subtle transcriptomic differences compared to morphological and functional distinctions.

The paper uses scRNA-seq to analyze alternative splicing regulation across neuronal cell types, revealing distinct splicing programs and RBPs involved in graded regulation.

The paper identifies an epigenomic factor linked to reduced activated microglia that mitigates the risk of Alzheimer's disease in APOE ε4 carriers.

The paper identifies gene expression changes in Alzheimer's disease pathology linked to cognitive impairment in hydrocephalus biopsies, showing microglial activation and loss of homeostatic genes.

The paper identifies molecularly distinct proprioceptor subtypes in muscle spindles and Golgi tendon organs using single-cell RNA sequencing and validates their functional roles.

This study uses snRNA-seq to identify distinct transcriptional states of astrocytes in Huntington disease, revealing gene expression changes compared to controls.

The paper identifies Hox gene-dependent mechanisms that govern the molecular diversity and connectivity of spinocerebellar tract neurons (SCTNs) involved in proprioception.

The paper identifies two types of motor cortex neurons with distinct roles in movement preparation and execution using single-cell profiling and axonal reconstructions.

The paper identifies shared and distinct transcriptomic cell types in two mouse neocortical regions using scRNA-seq, showing most excitatory types are region-specific while inhibitory types are shared.

The paper develops generalized leaky integrate-and-fire models to classify neuron types in the mammalian neocortex using electrophysiological data.