structural biology

This paper identifies a pH-sensing motif in PagC, an outer membrane protein, that drives bacterial vesicle production and aggregation at acidic pH using in situ NMR and EM.

This study benchmarks RNA 3D structure prediction models using varying accuracy 2D structures, finding that 3D models modify input base-pairing interactions and are more sensitive to false positives in 2D structures.

This study determines the structural plasticity of HIV-1 RRE stem-loop II and shows how it modulates Rev binding and nuclear export of viral RNA.

This study examines how blue light influences the photosynthetic apparatus of the seagrass Posidonia oceanica across different depths, identifying a novel PSI-LHCII supercomplex and depth-dependent structural adaptations.

This study identifies CtdA, a tRNA deacetylase that removes canavanine from mischarged tRNAArg, and reveals its structural and evolutionary relationships to B3/B4 domains.

This study uses deep learning and simulations to uncover the molecular mechanisms of TnsC filament assembly in a CRISPR-associated transposon.

The paper investigates the conformational dynamics of a histidine switch in the MrpA subunit of a cation/proton antiporter, showing how charge and protonation state changes drive proton transport.

The paper identifies toxic intermediate complexes formed during mitochondrial complex I assembly in NDUFS4 mutant mice, revealing hypoxia's role in rescuing disease by preventing pathological reverse electron transfer.

This study examines how two oncogenic histone mutations affect nucleosome stability through molecular dynamics simulations and biophysical assays, showing reduced interface stability and altered thermal properties.

This study reveals the structure of a hexameric phosphatase holoenzyme formed by a pathogen effector and host enzyme, showing enhanced stability and virulence function.

This study provides structural, kinetic, and biophysical insights into human ACOD1 to support drug discovery for cancer and inflammatory diseases.

The paper determines the crystal structures of New World arenavirus GP1-GP2 complexes, revealing structural differences from Old World counterparts and demonstrating their antigenic relevance for vaccine development.

This study identifies and characterizes novel Rv0183 inhibitors using high-throughput screening and X-ray crystallography, demonstrating species-selective inhibition against Mycobacterium tuberculosis.

The paper introduces local stability compensation (LSC) as a principle governing RNA folding, showing it is prevalent in RNA structures and validated through chemical mapping experiments.

This paper determines the structure of Escherichia coli PatZ, revealing its homotetrameric architecture and the role of the regulatory domain in catalytic activity and substrate specificity.

The paper uses an atomic model of the human cardiac thick filament to compute contributions of different components to X-ray diffraction patterns, confirming some interpretations and contradicting others.

This study compares conventional and CENP-A nucleosomes using high-pressure SAXS, revealing differences in their conformational stability and response to pressure.

This study compares isoleucine regulation of IlvA in Escherichia coli and Staphylococcus aureus, revealing structural differences in their regulatory domains and feedback mechanisms.

The paper determines the structure of HPAMPD, a mollusk adenosine deaminase with nucleotide specificity, and shows how it binds the 5-monophosphate group of AMP through specific structural elements.

The paper identifies and characterizes mini-bacterioferritin, a novel ferritin-like protein from an anaerobic methane-oxidizing archaeon, revealing its structure and evolutionary relationships.

This study determines the structure of the PelBC exopolysaccharide transporter in Pseudomonas aeruginosa and identifies its gating mechanism for exopolysaccharide transport.

This study shows FABP4 binds diverse PFAS with varying affinities and identifies three distinct binding modes through crystal structures.

The paper presents the first structure of a bifunctional terpene synthase, revealing its architecture and suggesting how GGPP might be transferred between domains.

This study identifies a histidine switch in C9CARD that regulates pH-dependent filament formation through electrostatic interactions and structural changes.

This study identifies five conformational states of Na+-NQR in Vibrio cholerae using mutants and inhibitors, revealing that 2Fe-2S reduction drives Na+ translocation through structural rearrangements.

The paper identifies PqqU as a high-affinity PQQ importer in Gram-negative bacteria, showing its structural basis and widespread distribution across diverse environments.

This paper shows that anle138b binds to a cavity in lipidic Aβ fibrils and reduces fibril formation by 75%, suggesting a potential therapeutic mechanism for Alzheimer's disease.

This study uses high-throughput MicroED to analyze structural dynamics of NaK and NaK2CNG ion channels, revealing sodium binding and dynamic selectivity filter behavior.