structural biology

This paper identifies an effector from Phytophthora infestans that bridges NbTOL9a to an activated NLR to suppress immunity, revealing a novel structural and functional mechanism.

This study presents three new crystal structures of STEP (PTPN5) revealing unexpected conformational features and ligand binding events that provide insights for structure-based drug design.

The paper reports the structure of the PSI-SOD supercomplex from Chromera velia, showing how energy conversion and oxidative stress protection are directly coupled.

This study uses multiscale modeling to show that microtubule plus-end tips bend outward into curved structures regardless of GTP hydrolysis state, challenging existing models linking curvature to nucleotide state.

The paper characterizes CryoRhodopsins from cold environments, revealing their dual functionality and structural adaptations to low temperatures.

This paper investigates the molecular mechanism of aminooxyacetic acid (AOAA) inhibition of MtbCBS, a key bacterial enzyme, using cryo-EM and computational methods, revealing critical residues and structural factors for irreversible inhibition.

This study determines the cryo-EM structure of SLC1A1 bound to an inhibitor, identifies its binding mechanism, and develops improved inhibitors with enhanced cytotoxicity in kidney cancer cells.

This study identifies ANTXR2 as the receptor for C. perfringens NetF toxin, revealing structural insights into its binding mechanism and pore formation.

This study determines the cryo-EM structure of the heterohexameric LGI1-ADAM22 complex and visualizes its dynamics using high-speed atomic force microscopy.

The paper shows that Sec18/NSF disassembles SNARE complexes through side-loading, overcoming topological constraints by threading the SNARE domain through the ATPase rings.

The paper presents structures of the yeast clamp loader RFC and shows PCNA facilitates nucleotide exchange by promoting ADP release through subunit separation.

The paper determines the structure of the insulin receptor complexed with a dimeric aptamer agonist, revealing how it induces full activation through specific conformational changes and intermolecular phosphorylation.

This study determines the structure of the complete extracellular bacterial flagellum, revealing mechanisms of flagellin incorporation and filament assembly.

This study reveals the conformational dynamics and membrane insertion mechanism of B4GALNT1 in ganglioside synthesis using crystal structures and molecular simulations.

A small molecule stabilizes the pre-activated state of arrestin-3, enhancing its binding to phosphorylation-deficient β2-adrenergic receptors.

The paper identifies structural determinants of the DM3 alpha/beta hydrolase that trigger NLR-mediated genetic incompatibility in plants by disrupting dimer interface integrity.

This study compares the conformational flexibility of Drosophila and bovine tubulins and links it to differences in microtubule dynamic instability.

The paper improves qFit-ligand to better model ligand conformations in structural data, enhancing analysis of conformational heterogeneity in ligand-bound structures.

This study shows that pathogen-induced neuronal signaling disrupts lysosomal function and collagen homeostasis in C. elegans, identifying NSIF-1 and ELT-3 as key regulators.

This study investigates how Class 4 and Class 5 antibodies modulate the conformational dynamics and immune escape of SARS-CoV-2 spike protein through allosteric effects and mutational scanning.

This study investigates the regulatory mechanism of RipA, a cell wall hydrolase in Mtb, through structural and functional analysis of the SteAB system.

The paper reports the cryo-EM structure of the RP4 conjugation pilus, revealing it is functional without phospholipid modification, challenging previous assumptions about pilus biogenesis.

The paper investigates how the Xre-RES toxin-antitoxin system from Pseudomonas putida regulates its own transcription through DNA binding and structural dynamics.

This paper combines AlphaFold with small-angle scattering data to predict multiple conformational states of a membrane protein under specific conditions and their transition pathways.

This study uses molecular dynamics simulations to analyze how TREM2 mutations affect the stability of the TREM2-DAP12 complex, revealing structural impacts on neuroimmune signaling in Alzheimer's disease.

This paper introduces a groupwise registration framework for longitudinal infant DTI images, improving alignment accuracy through clustering and sample-specific common space alignment.

The paper reports the crystal structure of fungal Trl1-LIG with a tRNA substrate, revealing conserved binding principles and RNA end specificity.

This paper reveals how the HCMV protein US6 inhibits the peptide-loading complex by altering TAP dynamics, providing insights into viral immune evasion mechanisms.

The paper presents a structural model of the closed Shaker potassium channel, revealing how voltage sensor movement drives pore opening and identifies a binding site for dalfampridine.

This study reveals that Arpin homodimerization enhances inhibition of Arp2/3 complex-mediated actin polymerization, suppressing cancer cell migration and metastasis.