structural biology

This study characterizes the structural evolution of Fcα/μR-mediated antibody recognition across vertebrates by analyzing duck and mouse Fc/R interactions with IgM and IgA.

The paper predicts a cohesin acetylation complex in budding yeast that interacts with nicked DNA and confirms its function through experiments.

This study identifies the endothelial protein C receptor (EPCR) as the entry receptor for Langya virus and reveals the molecular basis of its interaction with the viral attachment glycoprotein.

This study uses MAS NMR to determine the binding mode of HRF-4467, a second-generation HIV-1 maturation inhibitor, in the CA-SP1-NC11 complex with IP6, revealing its mechanism of action and resistance profile.

The paper identifies prokaryotic homologs of the major vault protein that assemble into vault nanocapsules, revealing structural and size variability.

This study investigates coenzyme specificity in yeast GDH3, showing how mutations alter coenzyme preference and revealing structural and evolutionary mechanisms of coenzyme regulation.

The paper investigates how SCN- induces prestin contraction through structural changes in its dimers and monomers, associated with altered intermonomer angles and beta sheet loss.

This study identifies distinct peripheral elements in senataxin that mediate R-loop unwinding and RNA polymerase II regulation through structural and biochemical analyses.

This study reports cryo-EM structures of full-length BCRs, revealing their dynamic conformation and antigen binding-induced signaling mechanisms.

The paper analyzes the structural and functional interactions of HERC2/UBE3A and HERC2/DOCK10 complexes to understand their role in Angelman and Dup15q Syndromes.

The paper investigates how ZEB85 activates TrkB by identifying a sulfotyrosine motif essential for agonist activation, while BDNF uses a different binding site.

The paper presents structures of hTRPC3 in resting and open states, revealing how the moonwalker mutation activates the channel by disrupting a polar interaction and inducing structural changes.

This study examines how mutations in the N-terminal domain of SARS-CoV-2 Spike affect antigenic properties and immune escape, finding that structural flexibility and loss of heme-metabolite interaction reduce antibody neutralization.

This paper describes a trimeric inhibitor, S22, that stabilizes the SARS-CoV-2 spike protein in a closed conformation, preventing ACE2 binding and viral entry.

SMARTFlexDB links ligand-bound and ligand-free RNA structures to study conformational flexibility and small-molecule recognition, providing a resource for RNA-targeted drug discovery.

The paper determines the structure of Llp and analyzes the FhuA:Llp complex to understand superinfection exclusion in bacteriophage T5.

This study defines the structural mechanism of metal-induced DNA release by the ArsR/SmtB repressor CadC using crystal structures and biochemical analyses.

This study determines the structural and mechanistic basis of FapB amyloid assembly in Pseudomonas, showing it forms cross-β-solenoid fibrils and interacts with FapC fibrils.

This study determines how the I-F3 CRISPR-associated transposase recognizes and pairs transposon ends for transposition using cryo-EM and biochemical analyses.

This study reveals how ATRX modulates chromatin by unwrapping nucleosomal DNA through a unique 'pin-like' structure and other features, proposing a 'climbing' mechanism for DNA translocation.

This study determines cryo-EM structures of NCBE, revealing ion binding sites and an inhibitor mechanism, and proposes an elevator-like transport mechanism for Na+-coupled HCO3- transporters.

The paper reports structural insights into how large serine integrases control directionality during DNA integration and excision using recombination directionality factors.

This study defines how ligand structure controls function in a LuxR-type quorum sensing receptor by presenting full-length structures bound to agonist and antagonist ligands.

The paper determines the structure of PTDSS2 from Equus caballus in complex with PE or serine substrates, revealing substrate binding sites and PLD activity.

The paper shows a dengue virus mutant lacking N153 glycosylation is more susceptible to neutralizing antibodies, as evidenced by increased Fab occupancy and slower dissociation rates.

This study reveals a bifunctional mechanism in TMAO demethylase where HCHO is channeled from a catalytic core to a THF-binding site, linking TMAO demethylation with one-carbon transfer.

This study identifies Rehh as a widespread bacterial toxin with DNase activity, revealing its evolutionary divergence and mechanism of neutralization by immunity proteins.

This study identifies a cholesterol-dependent mechanism by which the KSHV GPCR ORF74 regulates its constitutive activity through structural and functional analysis.

This study analyzes the structural and biochemical properties of BtuG homologs in B. thetaiotaomicron to understand their role in cobalamin scavenging.

This paper determines the structure of indoleacetate decarboxylase and challenges the proposed mechanism of skatole formation by showing it may follow a Kolbe-type decarboxylation rather than hydrogen atom transfer.