Tuberculosis Research and Epidemiology

This study identifies USP15 as a negative regulator of autophagy and macrophage immunity to Mycobacterium tuberculosis, showing that its inhibition reduces bacterial burden.

This study shows that ESAT-6 protein from Mycobacterium tuberculosis inhibits human monocyte differentiation into dendritic cells by suppressing NF-κB activation.

The paper uses long-read sequencing to generate complete genomes of Mycobacterium tuberculosis complex isolates, revealing increased genomic diversity and improved resolution in transmission analysis.

This study shows that Ag85A is essential for plasma membrane domain organization in mycobacteria, leading to mycolic acid accumulation and altered cell envelope structure.

A vaccine using rare variable antigens (RVMA) reduces lung pathology in mice without lowering bacterial loads during Mtb infection.

This study identifies PE11 as a factor that promotes Mtb persistence by inhibiting autophagy and lysosomal biogenesis through the FLCN-lactate-TFEB signaling axis, with lactate shown to enhance bacterial clearance.

This study investigates itaconate's role in human macrophages, showing distinct effects in alveolar-like and M-CSF-derived macrophages during M. tuberculosis infection.

The paper identifies distinct antibody-based signatures and functionalities in latent and active pediatric tuberculosis, highlighting differences in humoral immune responses that may inform diagnostic and therapeutic strategies.

This study identifies a novel mechanism by which rifampin shortens TB treatment by inhibiting Mtb RNA polymerase, leading to cell division arrest and reduced antibiotic resistance.

This paper shows sertraline enhances macrophage bactericidal activity against Mtb by rewiring cholesterol metabolism and activating inflammasome pathways.

This study shows that antibodies against Mtb enhance immunity via NLRP3 inflammasome activation in mice, independent of Fc receptors, and this mechanism applies to polyclonal sera in rhesus macaques.

This study evaluates a modified BCG vaccine overexpressing cyclic di-AMP, showing improved protection against TB in rhesus macaques.

This study identifies TREM2+ lipid-laden macrophages in alveolar TB pneumonia that support Mtb survival, contrasting with granulomas, and shows pharmacological reversal of this immunometabolic state.

This study shows that Mycobacterium tuberculosis adapts to acidic conditions by increasing growth-arrested cells, which enhance drug tolerance and survival.

This study shows sertraline improves bacterial control in TB models by enhancing the pharmacodynamic-pharmacokinetic properties of TB drugs without altering their distribution or clearance.

This study investigates how TB and COVID-19 co-infection affects the sputum microbiome, finding altered bacterial abundance and functional pathways that may impact treatment outcomes.

This study investigates the role of CwlM in beta-lactam resistance and intracellular survival in Mycobacterium smegmatis, finding it promotes resistance and supports survival in macrophages without PG-hydrolytic activity.

This study identifies a periplasmic protein complex in Mtb that supports arabinofuranosyltransferase activity and contributes to intrinsic drug resistance.

The paper reviews bead beating methods for Mycobacterium tuberculosis lysis, identifies protocol variability, and highlights the need for standardization to improve reproducibility.

The paper identifies RvD5-GPR32 signaling as a mechanism by which TB-PE reprograms macrophage metabolism to impair anti-tuberculous immunity.

This study investigates the regulatory mechanism of RipA, a cell wall hydrolase in Mtb, through structural and functional analysis of the SteAB system.

This study shows dexamethasone reduces glycolysis in human macrophages but enhances mycobacterial killing, suggesting a potential therapeutic benefit in tuberculosis.

This study determines the cryo-EM structure of the MmpS5L5 efflux pump in Mycobacterium tuberculosis and identifies mutations that enhance bedaquiline efflux, suggesting new resistance mechanisms.

The paper analyzes whole-blood RNA-seq data from TB patients to identify rRNA transcriptomic signatures that change during anti-TB treatment, suggesting potential biomarkers for monitoring treatment response.

The paper profiles macrophage diversity in TB granulomas using single-cell RNA sequencing and immunofluorescence in nonhuman primates, identifying distinct subsets and their roles in Mtb infection.

This paper identifies PE5, a Mycobacterium tuberculosis effector protein, as interacting with the host CRL2 ubiquitin ligase complex, modulating its activity without being ubiquitinated itself.

The paper identifies PhoP's role in regulating asparagine utilization in M. tuberculosis under acidic conditions, showing its importance for bacterial survival in host phagosomes.

This study identifies 64 FDA-approved drugs as potential host-directed therapeutics for tuberculosis using an integrative transcriptome-based approach combining multiple gene expression signatures and connectivity scoring methods.

The paper identifies dinucleotide substitutions in M. tuberculosis as markers of diversifying selection, revealing their role in drug resistance and virulence evolution.

This study investigates the role of PKCδ in macrophage immunomodulation during Mtb infection, finding that its deficiency leads to increased Mtb burden and exacerbated pathology.