Neurotransmitter Receptor Influence on Behavior

When does post-ingestive dopamine signaling occur in humans?

This study shows that post-ingestive dopamine signaling in humans is reduced 2 hours after a meal and varies with BMI and adiposity, suggesting a prolonged response beyond the early postprandial period.

Divergent Dopamine Dynamics within the Accumbens Core

This study reveals spatially organized dopamine dynamics in the nucleus accumbens core of mice, showing distinct patterns in anterior and posterior regions that do not align with canonical reward prediction error models.

Caudate dopamine predicts cognitive effort decisions both in the lab and daily life

This study shows that caudate dopamine-D2 receptor availability influences cognitive effort decisions in both lab tasks and daily life.

Chronic semaglutide treatment attenuates cue-induced reinstatement of cocaine-seeking and cocaine-induced stereotypy in male and female rats

This study shows that chronic semaglutide treatment reduces cue- and cocaine-induced reinstatement of cocaine-seeking in male and female rats.

The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors

This study shows that insular parvalbumin interneurons modulate impulsivity and alcohol consumption, with reduced activation linked to increased impulsivity and alcohol intake in adolescents.

Genetic background influences cocaine neuroplasticity in the accumbens shell of male mice

The paper investigates how genetic background affects cocaine-induced neuroplasticity in the accumbens shell of male mice across different strains and abstinence periods.

Using Light to Establish Habits in Laboratory Mice

This study validates an operant paradigm where mice lever-press for light as a reward, showing light can drive behavior independently of physiological needs or hedonic responses.

Coordinated yet asymmetric striatal neuromodulatory dynamics encode associative learning

This study tracks dopamine and acetylcholine dynamics in mice during associative learning, finding coordinated yet asymmetric interactions that shape behavioral state.

An accumbal cholinergic ISR-HCN2 axis sustains maladaptive cue motivation

The paper identifies an ISR-HCN2 cholinergic mechanism in nucleus accumbens interneurons that sustains maladaptive cue-driven motivation and shows HCN blockade reduces cue-seeking behavior.

Cholinergic interneurons in the nucleus accumbens regulate the initiation of natural reward approach

This study identifies NAc cholinergic interneurons as regulators of natural reward approach initiation by linking sensory input to motivated action.

Behavioural hyperactivity and risk-taking in young-adult male mice correlate with increased dopamine release in dorsal, but not ventral, striatum

The paper examines age and sex-dependent changes in dopamine release in dorsal and ventral striatum of mice, finding increased dorsal striatal release in males during adolescence to young adulthood, linked to behavioral changes.

Central lipid sensing tunes accumbal D2R-neuron activity in appetitive behaviours

This study shows that triglycerides modulate D2R-neuron activity in the nucleus accumbens during appetitive behaviors, with effects dependent on metabolic state and diet.

Striatal interneuron microcircuits gate reinforcement to stabilize adaptive choice

This study identifies a striatal interneuron circuit that gates reinforcement by linking outcome processing to adaptive action selection through disinhibitory microcircuitry.

Repeated cocaine reorganizes striatal ensembles along the ventral-dorsal axis

This study shows that repeated cocaine exposure reorganizes striatal neural activity patterns along the ventral-dorsal axis in mice, leading to distinct changes in neuronal responses.

A dopaminergic visuomotor gateway to the zebrafish optic tectum

The paper identifies a cluster of dopaminergic neurons in zebrafish that integrate visual and motor signals to modulate tectal circuits involved in sensorimotor transformations.

Serotonergic circuit architecture underlies sex dimorphism in anxiogenic states

This study identifies sex-specific differences in serotonergic circuit connectivity and gene expression in the dorsal raphe nucleus, linking these differences to sex-dependent anxiety-like behaviors.

Differential contributions of striatal dopaminergic pathways to visuomotor conditional learning

The paper investigates how different striatal dopaminergic pathways contribute to visuomotor conditional learning, finding that only nigrostriatal DA is necessary for learning.

Acute head shaking precedes chronic corpus callosum deficits during repeated cocaine exposure in common marmosets

This study shows that acute cocaine-induced head shaking precedes chronic corpus callosum deficits and identifies DPYSL2 and CRYAB as potential molecular markers of cocaine-induced white matter changes.

Glucose and fructose differently mediate alcohol cocktail drinking in female and male rats: interaction of glucose and alcohol on post-ingestive behavior

This study shows that glucose and fructose differently affect alcohol drinking in male and female rats, with glucose enhancing alcohol intake and influencing post-ingestive behavior.

Systemic administration of the mGluR2/3 antagonist LY341495 disrupts reward-related behaviors across ingestive and social domains in mice

This study shows that LY341495, an mGluR2/3 antagonist, reduces reward-related behaviors in mice across ingestive and social domains without affecting general motor function.

Selective dysregulation of serotonin dynamics in the anterior cingulate cortex and central amygdala following binge alcohol consumption

This study identifies region-specific serotonin signaling changes in the ACC and CeA after binge alcohol consumption, showing differential effects on reward and aversion behaviors.

Pavlovian conditioned approach with different reward magnitudes reveals opposing effects of acute and chronic semaglutide treatment

This study compares acute and chronic semaglutide effects on conditioned approach behavior in rats, finding chronic treatment increases sign-tracking while acute treatment decreases it, suggesting different impacts on reward-motivated behavior.

Reward expectation signals in the superior colliculus during associative learning

The paper investigates reward expectation signals in the superior colliculus during associative learning and finds that the SC carries a learned reward-expectation signal multiplexed with motor preparation.

The VGLUT3-p.T8I Mutation Alters Striatal Acetylcholine Dynamics in Response to Social Stressors and Drives Selective Social Avoidance in Male Mice

This study shows that the VGLUT3-p.T8I mutation in male mice alters striatal acetylcholine dynamics during social stress, leading to increased social avoidance and anxiety.

Dissociable control of persistence and adaptive updating in reward-guided behavior

This study investigates how the MCH system influences persistence and adaptive updating in reward-guided behavior using touchscreen tasks in rodents.

Neuronal Grin2c expression and the cocaine engram: a medial prefrontal cortex substrate for conditioned place preference

This study identifies Grin2c expression in mPFC neurons as a molecular component of cocaine-induced conditioned place preference engrams.

Supramammillary projections to the lateral preoptic area drive dopamine release and active behavior

The paper identifies the SuM[->]LPO pathway as a circuit that modulates dopamine release and active behavior through interactions with mesolimbic dopamine signaling.

Spatially confined dopamine from locus coeruleus axons selectively shapes hippocampal dynamics and action timing

The paper shows that localized dopamine from locus coeruleus axons selectively enhances specific hippocampal neurons during navigation, delaying action timing and improving reward anticipation.

Ketamine Modulates Endogenous Opioid Peptide Signaling and Reduces Heroin-Seeking in Male Long-Evans Rats

This study shows ketamine reduces heroin-seeking in rats by modulating endogenous opioid and glutamatergic systems, suggesting its potential as an OUD treatment.

Striatal dopamine dynamics across temporal scales in brain-specific Atp2a2 heterozygous knockout mice during reward conditioning

This study examines dopamine dynamics in Atp2a2 heterozygous knockout mice during reward conditioning, revealing context-dependent changes in dopamine signaling across temporal scales and striatal regions.