HIV Research and Treatment

The paper identifies minimal somatic hypermutations required for CD4bs bNAb neutralization breadth and uses structural data to guide HIV-1 vaccine immunogen design.

The paper shows that tazemetostat reduces HIV reservoirs and improves CD8+ T-cell function by increasing MHC-I expression and promoting anti-HIV immune responses.

This study investigates the immunogenicity and structure of a clade C HIV-1 Env trimer from a pediatric elite-neutralizer, showing it elicits strong autologous neutralizing antibodies and reveals key neutralizing epitopes.

This study shows that epigenetic modulation of NLRP6 reduces necroptosis and gastrointestinal inflammation in HIV/SIV-infected rhesus macaques.

This study shows that Mukungulu, an African medicinal plant extract, effectively reverses HIV-1 latency in humanized mice and human cells, outperforming standard controls.

This study identifies viral determinants in Vpr and Vpx proteins that enable antagonism of SAMHD1 and HUSH, revealing molecular plasticity in lentiviral adaptation to host restrictions.

This paper develops an in vitro model of SIV latency in rhesus macaque CD4+ T cells, generating latently infected cells that mimic in vivo reservoirs and enabling studies of latency mechanisms and cure strategies.

This study maps escape mutations from antibodies 10-1074 and 3BNC117 against HIV Envs from two strains, showing differences in mutation effects between strains.

This study investigates how lenacapavir affects HIV-1 capsid structure and nuclear entry by combining simulations and live-cell imaging, showing that it causes hyperstabilization and structural defects leading to capsid failure.

This study shows that antigen avidity affects the durability and diversity of vaccine-induced immune responses by influencing germinal center dynamics and B cell outcomes.

This study identifies INTS12 knockout as a method to enhance HIV latency reversal by overcoming a transcriptional block, improving reactivation in CD4 T cells from HIV-positive individuals.

This study shows CPSF6 promotes HIV-1 preintegration complex function by enhancing viral DNA integration into gene-dense regions and restoring integration activity when added back to mutant cells.

This study shows that sequential IL-15 and TGF-β1 stimulation expands HIV-specific CD8+T cells with enhanced effector functions, improving HIV control during treatment interruption.

This paper identifies ETS1 as a regulator of HIV latency through a CRISPR screen and shows it has opposing roles in actively and latently infected CD4 T cells.

The paper shows that PIP2 facilitates the incorporation of CD43, PSGL-1, and CD44 into HIV-1 particles by promoting their co-clustering with Gag at the plasma membrane.

The paper introduces a novel method for near-full-length HIV-1 genome sequencing using multiplex PCR and barcoding, enabling recombination event detection in clinical samples.

The paper investigates how vaccine antigen delivery and adjuvant selection affect the priming of rare HIV broadly neutralizing antibody-precursor B cells in non-human primates, finding that specific dosing and adjuvant combinations enhance their detection in germinal centers.

This study identifies Hsp90 as a master regulator of HIV-1 latency, showing its critical role in reactivation pathways and potential as a therapeutic target.

This study identifies DHX15 as an inhibitor of mouse APOBEC3 deamination, showing it suppresses MLV replication and prevents DNA damage.

This paper describes engineering hematopoietic stem cells to produce CCR5 knockout cells and secrete HIV-1 inhibiting antibodies, aiming for a one-time cure for HIV-1.

The paper identifies a mimotope of a gp41 HIV epitope related to a Hepacivirus non-structural protein linked to Kawasaki disease, showing no specific autoimmune correlation.

Simulations using a mechanistic HIV model show that interindividual variability in infection dynamics drives differential responses to HSCT, with remission dependent on donor-to-host immune cell ratios and better predicted by clinical observations than model parameters.

This study uses molecular dynamics simulations to show that N-linked glycans at positions N88 and N611 modulate HIV-1 Env tilting motion in a membrane environment.

The paper investigates factors regulating HIV-1 fusion in reverse, finding that Env activity depends on cell surface levels, is inhibited by a fusion inhibitor, and is influenced by lipid membrane composition.

This study examines CpG methylation changes in CCR5 and CXCR4 promoters in HIV-1-infected individuals over time, finding significant methylation variability in CCR5 and decreases in specific CpG sites.

This study shows that non-infected CD4+ T cells enhance replication of primary HIV-1 in macrophages and promote formation of virus-containing compartments (VCCs).

This paper develops a stochastic model to study HIV viral rebound after ART discontinuation, showing that immune fluctuations and stochastic reactivation dynamics shape rebound risk.

This study investigates how extracellular vesicles carrying microRNA-155 influence HIV-1 infection in humanized mice and identifies EVs as biomarkers of immune dysfunction.

The paper identifies an early expansion of adaptive NK cells during acute HIV-1 infection that correlates with long-term viral control.

The paper identifies CD34 as an intrinsic innate immune factor that restricts retrovirus replication in stem cells by inactivating progeny virions.