Sperm and Testicular Function

The paper creates a single-cell atlas of the murine epididymis and vas deferens, identifying cell types and their regional specialization, and revealing potential signaling networks.

This study investigates Prm2 deficiency in mice, showing it leads to oxidative stress and DNA damage during sperm maturation, affecting fertility.

This study shows DAZL regulates spermatogonial progenitor expansion and differentiation by enhancing translation of its target genes.

The paper identifies biallelic M1AP mutations as a cause of meiotic arrest and male infertility through whole exome sequencing and cohort screening.

This study identifies a conserved piRNA locus, pi6, essential for male mouse fertility and embryo viability by regulating sperm function through mRNA cleavage.

The paper uses single-cell RNA sequencing to compare spermatogenesis in human, macaque, and mouse testes, identifying conserved and divergent molecular features across species.

The Male Fertility Gene Atlas aggregates and integrates OMICs data from publications on male infertility to enable targeted search and meta-analysis of genetic and epigenetic factors.

The paper identifies a recessive allele in WDR19 associated with reduced semen quality and male fertility in cattle, showing it activates cryptic splicing and reduces protein expression.

The paper identifies a NANOS1 mutation that switches its function from anti-apoptotic to pro-apoptotic in human germ cells by disrupting repression of pro-apoptotic genes.

The paper analyzes vertebrate sperm protamine sequences to identify conserved residues and proposes dityrosine or cysteine-tyrosine cross-linking as mechanisms for protamine structure in metatherians.

This study shows HIPK4 is essential for spermiogenesis and male fertility in mice, with defects in sperm head morphology and fertility.

This study identifies MGAT4D as a protective factor for male germ cells against mild heat stress, showing that its absence increases sensitivity to heat.

This study develops an automated platform to screen compounds against human sperm motility and acrosome reaction, identifying new contraceptive candidates from a large molecular library.

This study identifies NHR-23/NR1F1 as a critical regulator of spermatogenesis in C. elegans, functioning downstream of the sex determination pathway and independent of the SPE-44 network.

This study identifies distinct epigenetic programming in regenerative spermatogonial stem cells and progenitors in mouse testis using integrative epigenomic analysis.

This study identifies SYCP2 translocation and frameshift variants as causes of male infertility through genetic analysis and functional modeling in yeast.

This paper shows that Fbxo7 is required for male fertility in mice, as its deficiency leads to sterile males with abnormal spermatid disposal during spermiogenesis.

This study shows that cyclin B3 is not required for male meiosis despite its meiosis-specific expression, as male mice lacking cyclin B3 are fertile with normal spermatogenesis.

This study shows androgen promotes differentiation of PLZF+ spermatogonia via an indirect regulatory pathway involving Sertoli cells and multiple intermediate molecules.

The paper shows BRG1 interacts with SCML2 to regulate transcription during spermatogenesis, highlighting a novel SWI/SNF-PRC1 co-operation mechanism.

This study characterizes the porcine sperm transcriptome through RNA-seq, identifying seasonal changes in gene and microRNA expression related to oxidative stress and DNA damage.

The paper identifies a splice donor variant in CCDC189 associated with asthenospermia in Nordic Red cattle and integrates findings into the OMIA database.

This study examines the small RNA profile of house sparrow sperm to explore how paternal age affects offspring fitness, finding no significant differences in miRNA and tRNA fragments between aged and prime sperm.

This study uses single-cell RNA sequencing to analyze transcriptional changes in spermatogonia and spermatocytes across developmental stages, revealing age-related gene expression differences and pathway utilization.

The paper creates a single-cell transcriptomic atlas of mouse spermatogenesis, identifying key developmental stages and X chromosome transcriptional dynamics.

This paper systematically reviews and assesses the clinical validity of genes linked to human male infertility, identifying 67 confidently linked genes across 81 phenotypes.

The paper develops a program to quantify and categorize nuclear morphology in mouse sperm, finding increased shape variability in lab lines compared to wild-derived lines and subtle cross-direction effects in F1 offspring.

The paper describes a method using Cre-lox technology and flow cytometry to label and isolate distinct stages of mouse spermatogenic cells for molecular analysis.

This study identifies that elevated temperature primarily reduces male fertility in C. elegans by impairing mating behavior and sperm transfer, not sperm production or function.

The paper identifies spatially restricted nucleosome domains in human sperm chromatin associated with fertility, revealing a new epigenetic structure linked to male infertility.