Retinal Diseases and Treatments

In a mouse branch retinal vein occlusion model, retinal ganglion cells die progressively over 14 days. α-RGCs and F-RGCs are lost fastest, and TBR2-positive intrinsically photosensitive RGCs survive best.

This study identifies PDGFD-ROCK-NMIIA signaling in pericytes as a driver of pathological neoangiogenesis in retinopathies, revealing cell-type-specific actomyosin contractility mechanisms.

This study shows that loss of FXR signaling in mice promotes choroidal neovascularization, fibrosis, and vascular leakage, suggesting FXR as a therapeutic target for nAMD.

This study identifies a truncated form of CRYAB, DTCAMD, as a potential therapeutic target for subretinal fibrosis in nAMD.

This paper develops an inducible ARPE-19 cell model of hydroxyapatite mineralization, mimicking AMD drusen features and revealing transcriptional changes and mineral deposition inhibition.

The paper examines how aging and Nrf2 deletion affect visual function and gene expression in the retina and RPE-choroid, finding exacerbated age-related declines in Nrf2-deficient mice.

This study identifies age-related proteomic and metabolic changes in the retina and RPE/Cho of mice, revealing tissue-specific and age-dependent shifts in metabolic pathways.

This paper creates a mouse model with the ARMS2A69S variant to study AMD, finding it causes mitochondrial dysfunction and AMD-like phenotypes.

This study uses single-cell RNA sequencing to analyze MAC-bound cells in human choroid, revealing patterns of complement deposition and regulator expression in AMD.

This study shows hyperglycemia increases photoreceptor production of inflammatory factors, which activate Muller glial cells and promote neuroglial inflammation in diabetic retinopathy.

This study identifies metabolic differences between regions and tissues in the human retina and RPE/choroid using targeted metabolomics.

This study examines how different nutrient microenvironments affect RPE cell phenotype, function, and metabolism in iPSC and fetal RPE, identifying key metabolic shifts and phenotypic changes.

The paper identifies multiple cell lineages contributing to myofibroblasts in subretinal fibrosis and shows that miR-24 regulates pathways involved in fibrosis, with SMAD3 and MRTF inhibitors showing therapeutic potential.

The paper identifies expression changes in AMD risk genes using single-cell eQTL analysis across AMD stages and tissues.

This study shows that the CFH Y402H variant makes choriocapillaris endothelial cells more susceptible to oxidative stress and complement dysregulation, linking these factors to AMD pathogenesis.

The paper develops a microtissue-based platform to test antifibrotic drugs using retinal pigment epithelium cells, showing fibrotic phenotype induction and drug response.

This study shows that dietary serine reduces ROS accumulation and improves retinal function in AMD by restoring mitochondrial function and GSH levels through PHGDH regulation.

This study investigates the role of alanine transaminase (ALT) in human neural retina metabolism, showing its involvement in carbon/nitrogen flux and redox balance, with potential therapeutic implications for retinal diseases.

This study identifies a diet-induced metabolic-immune axis linking gut microbiome changes to systemic immune aging and retinal degeneration in mice and AMD patients.

This paper reviews mitochondrial transplantation for eye diseases and evaluates delivery methods, finding that different routes target distinct retinal areas and show feasibility for further study.

This study analyzes metabolites in human retinal pigment epithelium and choroid tissue across aging and macular degeneration stages, identifying key metabolic changes associated with aging.

This study uses a computational model to explore how Muller cell orientation affects oedema and treatment response in Diabetic Macular Oedema.

This study shows L-DOPA treatment sustains neurovascular and synaptic function in diabetic retinas, with effects lasting after treatment ends.

This study investigates how the CFH Y402H polymorphism and cigarette smoke extract affect lipid metabolism in iPSC-derived RPE cells, revealing genotype-dependent differences and CSE-induced lipid changes.

This study shows hyperglycemia reduces Caspr1 expression in retinal neurons via Akt and C/EBP pathways, promoting neurite outgrowth, while insulin treatment under hyperglycemia decreases Caspr1 and shortens neurites.

The paper identifies HTRA1-AS1 as a genetic risk factor for AMD through transcriptome-wide association and fine-mapping analyses.

The paper identifies a 5-SNP block in the ARMS2 promoter that binds c-ABL and is associated with AMD, showing reduced transcriptional activity in reporter assays.

This study shows that turquoise killifish develop AMD-like features with age, making them a suitable model for studying age-related macular degeneration.

Inhibiting cholesterol esterification limits retinal neurovascular injury in diabetes.

The paper develops an anti-vitronectin antibody that reduces drusen accumulation and complement pathway activation in an in vitro model of age-related macular degeneration.