Developmental Biology and Gene Regulation

The paper identifies Delta-dependent Notch activation as a mechanism that terminates neuroblast temporal programs and promotes lineage progression in Drosophila.

The paper investigates how BMP signaling dynamics self-organize to generate repeating digit patterns in tetrapods, using single-cell RNA-seq and mathematical modeling.

This study shows that mechanical signaling between myosepta and the notochord sheath coordinates spinal segmentation in zebrafish.

The paper identifies mTORC1 and 7mG-cap dependent translation as regulators of spatial positioning of blastomeres during the 8- to 16-cell transition in mouse embryos.

The paper identifies Pri smORF peptides as pleiotropic regulators of leg development in Drosophila, functioning through Ubr3-dependent and -independent mechanisms in patterning and cell survival.

The paper proposes a 'tissue code' consisting of five mathematical laws that govern tissue organization and self-renewal dynamics, with implications for wound healing and disease.

The paper investigates how signalling networks and tissue flows interact during vein refinement in Drosophila pupal wings, showing that cell fate adjustments, not large-scale flows, drive precise patterning.

The paper investigates how Notch signaling and Hes factors regulate mucociliary cell fate specification in Xenopus tadpole epidermis through competitive de-repression.

The paper shows that stochastic fluctuations and entropy, not stiffness gradients, drive neural crest cell ingression in mice.

The paper reconstructs lineage trees of hindbrain rhombomeres in zebrafish using in vivo imaging and automated processing, revealing their spatial and temporal organization during development.

This study maps the transcriptional and regulatory changes during mouse somitogenesis, showing accelerated differentiation and lineage-specific programs.

This study shows that Ano10/Tmem16k is required for convergent extension and tubulogenesis during notochord formation in Ciona intestinalis.

This study identifies Six3 as essential for lens formation in Xenopus, acting independently of Pax6 through BMP and Notch signaling.

The paper develops LoxCode barcoding to trace clonal fate of epiblast cells in vivo, finding lineage biases and tissue-specific contributions across fetal development.

The paper shows Vangl in the pulmonary mesenchyme, not the airway epithelium, is critical for mesenchymal thinning and sacculation during lung development, independent of Celsr1.

This study maps the spatiotemporal dynamics of Notch2 signaling from membrane to nucleus after ligand activation, identifying key molecular events in signal transmission.

The paper uses a computational model and experiments to show that small micro-patterned mPSC colonies exhibit spontaneous asymmetry in BRA-GFP patterns, suggesting a mechanism for symmetry-breaking in development.

The paper identifies organ-founder stem cells that mediate post-embryonic neuromast formation in medaka fish, showing their dynamic behavior and role in organogenesis.

The paper investigates the dynamic interaction between Opa/ZIC and Oc/OTX in regulating head development, finding that Opa and Oc compete for gene regulation in different developmental stages.

The paper investigates the formation of the cephalic furrow in Drosophila gastrulation, showing it is driven by a mechanical wave initiated by pacemaker cells and controlled by genetic patterning.

The paper investigates the function of Hox genes lab and Dfd in chelicerates, showing their role in head segment patterning and homeotic transformations through RNAi experiments and expression analysis.

This study investigates the roles of nanos homologs in Bombyx mori germline development, finding that nosP is critical for fertility while nosO has limited involvement in PGC specification.

This study identifies NMY-2, TOE-2, and PIG-1 as regulators of Daughter Cell Size Asymmetry in C. elegans asymmetric divisions, showing distinct cortical localization and functional roles.

The paper shows that BMP signaling in human pluripotent stem cells induces mesodermal differentiation through timed pulses rather than concentration, involving combinatorial interactions with WNT signaling.

The paper shows that minor spliceosome inhibition in mouse forelimbs causes transcriptomic stalling and developmental delay, leading to micromelia while maintaining segmentation.

The paper identifies SRGP-1 and AFD-1 as regulators of HMP-1/α-catenin stabilization at rosettes during cleft closure in C. elegans gastrulation.

The paper introduces an improved Erk biosensor to study Erk signaling dynamics in zebrafish and Drosophila embryos, revealing oscillatory dynamics driven by mitotic erasure.

The paper identifies cross-lineage dependencies in gastruloid development by analyzing single-cell chromatin accessibility, showing that paraxial mesoderm is required for spinal cord formation through cell-cell interactions.

The paper examines the dynamics of BMP signaling in Drosophila embryos and finds that target gene activation persists even after the signal is lost, suggesting a memory mechanism.

The paper shows that β-catenin signaling patterns the oral-aboral axis in Nematostella vectensis, but endoderm specification occurs opposite to nuclear β-catenin accumulation, suggesting this mechanism is a Bilateria-specific co-option.