Pregnancy and preeclampsia studies

Shared Genetics of Hypertension and Preeclampsia Converges on Immune Regulation

The paper identifies shared genetic variants between hypertension and preeclampsia that regulate immune-related genes, linking gene expression to blood pressure traits and clinical phenotypes.

Osteopontin Mediates Uterine Artery Dysfunction in Hypertensive Pregnancy

This study identifies osteopontin as a mediator of impaired uterine artery remodelling in hypertensive pregnancy, showing its deficiency improves vascular function and fetal growth.

Ferumoxytol dynamic contrast-enhanced MRI for in vivo longitudinal cotyledon perfusion assessment with pathology correlation in a rhesus macaque thrombotic injury model

This paper uses ferumoxytol DCE-MRI to track placental cotyledon perfusion in rhesus macaques and correlates it with thrombotic injury pathology across gestation.

Gestational inhalation of nanoparticles disrupts placental zone structure and induces vascular placentation in rats

This study shows that nanoparticle inhalation during pregnancy reduces placental zone size but increases vascular adaptations in rats, potentially preserving nutrient exchange.

Maternal hypertension and cardiovascular medications dysregulate placental arterial tone

This study investigates how maternal hypertension and cardiovascular medications affect placental arterial tone, finding that certain drugs alter vascular reactivity and may impact placental perfusion.

Maternal and fetal HLA heterozygosity in preeclampsia: Insights from a large multi-ancestry pregnancy cohort

This study examines the association between maternal and fetal HLA heterozygosity and preeclampsia risk in a large multi-ancestry cohort, finding protective and risk associations for specific HLA loci.

An Integrated Proteomics and Genomics Approach to Identify Essential Protein Kinases During Human Trophoblast Development

The paper identifies essential protein kinases in human trophoblast development using proteomics and genomics integration, showing their roles in different cell types and suggesting potential therapeutic targets.

PPARG directs trophoblast cell fate and establishment of the uterine-placental interface

This study identifies PPARG as a critical regulator of trophoblast cell differentiation and uterine-placental interface formation in both human and rat models.

Acute exposure to cell-free mitochondrial DNA induces pregnancy-specific aortic endothelial dysfunction and organ-selective inflammation in rats

This study shows that acute exposure to cell-free mitochondrial DNA in pregnant rats causes aortic endothelial dysfunction and organ-specific inflammation, with partial TLR9 involvement.

Transcriptomic Analysis of Plac1 Ablation Reveals Broad Alterations in Signaling Pathways Essential for Prenatal Development and Overlap with a Preeclampsia-Associated Signature

This study uses gene expression microarrays to analyze placental gene expression changes in Plac1 knockout mice, identifying significant down- and upregulated genes and their involvement in developmental and preeclampsia-related pathways.

Maternal high fat diet and acute viral mimic exposure impact placental inflammation, lipid peroxidation and cellular proliferation-to-death ratio across mouse pregnancy

Vascular endothelial growth factor receptors 1 and 3 mediate placental trophoblast leptin production in preeclampsia, inducing vascular dysfunction

This study shows that sFlt-1 in preeclampsia increases trophoblast leptin production via VEGFR1 and 3, leading to vascular dysfunction.

The pro-inflammatory cytokines IFN-α and TNF-α inhibit organoid-derived extravillous trophoblast invasion

This study shows that IFN-α and TNF-α reduce EVT invasion in organoid models, potentially contributing to pregnancy complications.

SERPINA3 and NDRG1 are critical diagnostic immune genes associated with macrophages in preeclampsia

This study identifies SERPINA3 and NDRG1 as critical immune genes associated with M2 macrophages in preeclampsia using machine learning and experimental validation.

Complement activation in maternal and placental pathology of preeclampsia

This study develops a mouse model to investigate how timing of placental complement activation influences preeclampsia-like pathology, showing distinct maternal and fetal outcomes based on activation timing.

From Stress to Survival: Trophoblast-Derived Extracellular Vesicle Proteome Captures Aspirin-Driven Cellular Reprogramming in a Preeclampsia Model.

This study examines how aspirin affects trophoblast-derived extracellular vesicles in a preeclampsia model, identifying dose- and timing-dependent molecular changes linked to angiogenic recovery and inflammation.

Cross-species insights into placental evolution and diseases at the single-cell resolution

This study constructs a cross-species single-cell transcriptomic atlas of placentas across ten mammalian species, revealing trophoblast lineage dynamics and gene regulatory networks linked to placental evolution and disease.

Physics-informed stereology for estimating placental diffusive exchange capacity

The paper evaluates stereological methods for estimating placental diffusive exchange capacity using virtual histology and computational modeling, finding systematic overestimation of diffusive length scale by 15-25%.

Searching for influencers among placental immune cells in preeclampsia.

The paper identifies SPP1 and CD44 as influencers of inflammation in preeclampsia by analyzing single-cell transcriptional profiles of placental immune cells.

Low maternal plasma apelin in the second trimester is associated with adverse pregnancy outcome in severe, early-onset fetal growth restriction

High-salt diet disturbs the physiological uterine endothelial junction remodeling during pregnancy

This study shows that a high-salt diet disrupts uterine endothelial junction remodeling during pregnancy, leading to hypertension and adverse outcomes in mice.

Chronic replication stress-mediated genomic instability disrupts placenta development in mice

This study shows that replication stress from MCM2-7 mutations impairs placenta development in mice by reducing junctional zone proliferation and stemness, leading to poor embryo viability.

BAP1 dysregulation impairs trophoblast differentiation and contributes to placental dysfunction in preeclampsia

This study identifies BAP1 dysregulation as a contributor to placental dysfunction in early-onset preeclampsia by impairing trophoblast differentiation.

Endogenous retroviral elements LTR8B and MER65 rewire PSG9regulation to control trophoblast syncytialization and pre-eclampsia risk

The paper identifies retroviral elements LTR8B and MER65 that regulate PSG9 expression, influencing trophoblast syncytialization and pre-eclampsia risk.

Distinct DNA Methylation Signatures in Maternal Blood Reveal Unique Immune Cell Shifts in Preeclampsia and the Pregnancy-Postpartum Transition

This study uses DNA methylation profiling in maternal blood to identify immune cell shifts in preeclampsia and the pregnancy-postpartum transition, finding reduced monocyte proportions in PE.

Human umbilical mesenchymal stem cell-derived mitochondria ameliorate maternal phenotype by improving placental mitochondria and vascular function in angiotensin II-induced preeclampsia rat

This paper demonstrates that human umbilical mesenchymal stem cell-derived mitochondria transplantation improves placental mitochondrial function and vascular health, reversing preeclampsia symptoms in a rat model.

Single-cell sequencing of trophoblasts in preeclampsia and chemical hypoxia in BeWo b30 cells reveals EBI3, COL17A1, miR-27a-5p, and miR-193b-5p as hypoxia-response markers

The paper identifies hypoxia-response markers in trophoblasts from preeclampsia and chemical hypoxia models using single-cell and small RNA sequencing.

Systemic immune dysregulation in hypertensive disorders of pregnancy persists years after delivery

This study identifies persistent immune dysregulation in women with hypertensive disorders of pregnancy years after delivery, linked to increased cardiovascular disease risk.

Amyloid-β fibrils accumulated in preeclamptic placentas suppress syncytialization of cytotrophoblasts

This study shows that amyloid-β fibrils in preeclamptic placentas inhibit cytotrophoblast syncytialization, impairing placental function and contributing to preeclampsia.

Decoding human placental cellular and molecular responses to maternal obesity and fetal growth

The paper identifies placental cell-type-specific transcriptional responses to maternal obesity and fetal growth using single-nucleus RNAseq and microfluidic organoids.