Lipid Membrane Structure and Behavior

Clustering of SARS-CoV-2 membrane proteins in lipid bilayer membranes

This study shows that M protein interactions alone can drive clustering in ERGIC-like lipid bilayers, with direct interactions being stronger than membrane-mediated ones.

Membrane-anchored mobile tethers modulate condensate wetting, localization, and migration

This study develops a theoretical framework to show how membrane-anchored mobile tethers influence condensate wetting, localization, and migration by modifying surface tension and contact angle.

Study of Protein-Protein Interactions in Septin Assembly: Multiple amphipathic helix domains cooperate in binding to the lipid membrane

This study uses molecular dynamics simulations to show how amphipathic helix domains cooperate in binding to lipid membranes, stabilizing septin structures.

Dynamic Architecture of Mycobacterial Outer Membranes Revealed by All-Atom Simulations

The paper uses molecular dynamics simulations to reveal the unique architecture of the mycobacterial outer membrane, showing fluid outer leaflets and ordered inner leaflets that contribute to bacterial resilience.

Using DNA origami to study nanoscale organization of plasma membranes

This study uses DNA origami probes to investigate nanodomain organization and dynamics in plasma membranes by tracking their movement and interactions with nanodomains.

Missense mutations on SynGAP C2 domain impair membrane diffusion

The paper investigates how missense mutations in the SynGAP C2 domain affect membrane diffusion dynamics through molecular simulations and structural analysis.

Active regulation of the epidermal growth factor receptor by the membrane bilayer

This study shows that the lipid composition of the membrane actively regulates EGFR conformation and signaling, independent of ligand binding, with implications for cancer and normal cell function.

Large-scale endoplasmic reticulum membrane solidification spatially organizes proteins under thermal or metabolic stress

The paper identifies a temperature- and lipid saturation-dependent transformation of ER membranes into rigid tubes under stress, driven by lipid demixing and protein segregation.

Curvature-mediated prewetting organize mitochondrial nucleoid

This study shows membrane curvature drives prewetting transitions that organize mitochondrial nucleoids through localized protein condensation.

Direct Membrane Penetration of Oligoarginines by Fluorescence and Cryo-electron Microscopy Combined with Molecular Simulations

This study uses fluorescence, cryo-EM, and simulations to show how R9 peptides interact with membranes, causing structural changes like budding and stacking, and proposes a unified mechanism for their penetration.

LipoTag: A minimal motif for live and functional imaging of plant cell membranes.

The paper introduces LipoTag, a chemical motif that enables functional imaging of plant cell membranes by making hydrophobic fluorophores water-soluble and wall-permeable.

Alcohols inhibit glucose transporters noncompetitively at a constant membrane concentration according to lipid theory

The paper shows alcohols inhibit glucose transporters noncompetitively at a constant membrane concentration, supporting the lipid theory over the protein theory.

Accurate determination of the preferred aggregation number of a micelle-encapsulated membrane protein dimer

The paper determines the preferred aggregation number of DPC micelles encapsulating a membrane protein dimer using molecular dynamics simulations and finds it differs from the pure micelle value.

Osmotically Induced Shape Changes in Membrane Vesicles

This paper develops a free-energy framework to model osmotically induced shape changes in membrane vesicles, showing significant deviations from classical predictions.

Application of D4 Fluorescent Probes for Quantitative and Spatial Analysis of Cholesterol in Cells

This paper introduces fluorescent D4 probes for quantitative and spatial cholesterol analysis in cells, preserving native membrane environments.

Recombinant protein platform for high-throughput investigation of peptide-liposome interactions via fluorescence anisotropy depolarization

This paper introduces a recombinant protein platform to measure binding affinity of inducible amphipathic helices to membranes using fluorescence anisotropy.

Lipid-conjugated DNA enables on-demand delivery of lipids and proteins to synthetic cells

This paper introduces lipid-conjugated DNA (LiNA) to enable programmable fusion between LUVs and GUVs, demonstrating efficient delivery of lipids and proteins to synthetic cells.

Stretching drives Membrane Homogenization of Phase-Separated Supported Lipid Bilayers

This study shows that stretching supported lipid bilayers with phase separation leads to homogenization, consistent with a second-order phase transition, indicating membrane tension regulates lateral organization.

Mechanistic Insights into the Selective Targeting of MLX to Triacylglycerol-Rich Lipid Droplets

This paper investigates how MLX selectively binds to triacylglycerol-rich lipid droplets by analyzing sequence-specific interactions and membrane property changes.

Detergent exchange from lipid nanoparticles into detergent micelles unlocks a tool for biochemical and kinetic characterization of membrane proteins

This paper introduces a detergent exchange method to transfer membrane proteins from lipid nanoparticles to detergent micelles, preserving function and homogeneity for biochemical analysis.

Asymmetric phosphoinositide lipid bilayers generated by spontaneous lipid insertion

This study presents a method to generate asymmetric phosphoinositide lipid bilayers by spontaneous insertion of PI(4,5)P2, demonstrating its mobility and functional recruitment of actin-related proteins.

From Molecular Insight to Mesoscale MembraneRemodeling: Curvature Generation byArginine-Rich Cell-Penetrating Peptides

This study investigates how arginine-rich peptides like R9 induce membrane curvature through molecular simulations and multiscale modeling, revealing their role in cell penetration mechanisms.

Studying macromolecular composition in cell-cell interfaces using 3D membrane reconstitution systems

This paper develops artificial and semi-artificial 3D membrane systems to study protein, lipid, and glycocalyx distribution at cell-cell interfaces, revealing differential partitioning and activation dynamics.

The disordered and structured regions of α-Synuclein contribute to membrane remodeling synergistically

This study shows that α-Synuclein's structured N-terminal domain and disordered C-terminal domain work together to enhance membrane remodeling through synergistic electrostatic and curvature effects.

Protein-free membrane fusion: a refined view of the delicate fusogenic properties of calcium

This study quantifies calcium-mediated fusion in giant unilamellar vesicles (GUVs) and identifies conditions under which calcium can drive full fusion without proteins.

RNA at Lipid/Water Interfaces: Molecular Insights from Coarse-Grained Simulations and Reflectivity Data Predictions

This paper uses coarse-grained simulations and reflectivity data to study RNA-lipid interactions at interfaces, showing how RNA structure affects binding and validating simulation results with experimental data.

Asymmetry-induced transient gel formation in fluid lipid membranes

This paper shows that lipid membrane asymmetry can induce transient gel-like domains, altering membrane rigidity and curvature preferences.

Comparative Analysis of Structural and Dynamical Properties of Lipid Membranes Simulated with the AMBER Lipid21 ForceField Using SPC/E, TIP3P, TIP3P-FB, TIP4P-FB, TIP4P-Ew, TIP4P/2005, TIP4P-D, and OPC Water Models

The paper compares lipid membrane simulations using different water models with the AMBER Lipid21 force field, finding SPC/E provides the best structural and dynamic agreement with experiments.

Stearic acid enhances membrane fluidization and peptidoglycan stiffness to promote the stability of Gram-positive bacteria

This study shows stearic acid increases membrane fluidity and peptidoglycan stiffness in Gram-positive bacteria, enhancing their viability.

Introducing a fusogenicity metric for lipid nanoparticle formulation

The paper introduces a fusogenicity metric using small angle X-ray scattering to quantify lipid nanoparticle fusion capabilities and validates it with experimental assays.