Ion channel regulation and function

This study shows that α2δ-2 is essential for coupling calcium entry to two postsynaptic signals in Purkinje cells.

The paper presents a cryo-EM structure of the human CaV2.2 complex, revealing the closed-state inactivation mechanism through the blocking-ball formed by the W-helix.

This paper characterizes the functional impact of the SCN1AA1783V variant in Dravet syndrome by combining electrophysiology, computational modeling, and in vitro validation, showing impaired interneuron firing due to altered channel activation.

This study shows that Vc1.1 modulates GIRK1/2 channels via GABAB receptor activation, reducing neuronal excitability and providing insights for non-opioid pain treatments.

The paper quantifies developmental changes in voltage-gated sodium channel exon expression in human and mouse neocortex, identifying key splicing transitions associated with neurological disorders.

This study identifies TRPC3 and NALCN channels as key contributors to pacemaking in substantia nigra dopaminergic neurons through sustained inward currents.

The paper shows that increasing axial resistance at the axon hillock lowers the spike threshold in L5 pyramidal neurons, supporting resistive coupling theory.

The paper models how axonal diameter, myelination, and Na/K pump density interact to affect resilience to high frequency spiking.

The paper shows that loss of NaV1.2 sodium channels in pyramidal neurons leads to hyperexcitability and seizures despite reduced action potential size and speed.

The paper presents cryoEM structures of GIRK2 with and without cholesterol analog and PIP2, revealing how CHS modulates channel function by interacting with PIP2 in the transmembrane domain.

This study shows that severe NaV1.2 deficiency increases neuronal excitability in adult mice, challenging the current understanding of its role in autism and epilepsy.

The paper identifies an unconventional conductance essential for pacemaking in nigral dopamine neurons using pharmacological evidence and electrophysiological analysis.

This study develops a photocaged saxitoxin derivative to precisely control voltage-gated sodium channel blockade and demonstrates its effects on action potential propagation in neurons.

This study shows calbindin regulates Kv4.1 trafficking and neuronal excitability via CaMKII-dependent phosphorylation, linking Ca2+ buffering to neuronal function.

This study investigates the role of Kv4 channels in SNc DA neurons, showing Kv4.2 also contributes to IA and demonstrating IA gating kinetics and IH interactions determine pacemaking and post-inhibitory responses.

The paper uses GEVIs to show that voltage-gated potassium channels maintain action potential shape fidelity in distal axons of hippocampal neurons.

This paper combines perforated patch-clamp recordings with the added buffer approach to accurately quantify neuronal Ca2+ handling properties, including both immobile and mobile buffers.

This study investigates the role of Kcns3 in PV neuron function using computational models and electrophysiology in Kcns3-deficient mice, finding disruptions in firing patterns and gamma oscillations.

The paper investigates calcium channel distribution in the axon initial segment of mouse neurons and finds distinct functional roles for CaV2 and CaV3 channels.

The paper investigates how HCN and TASK-like channels affect dendritic impedance in layer 5 pyramidal neurons, finding that their combination best matches experimental impedance profiles.

This study shows ultrasound activates TRAAK K+ channels directly through the lipid membrane, with kinetics similar to mechanical activation, suggesting mechanosensitive channels mediate ultrasound's effects on neurons.

This study creates a Drosophila model with a hSlo1 D434G mutation, showing motor dysfunction and altered action potentials linked to BK channel gain-of-function.

This study identifies key residues in APETx1 and hERG that mediate inhibition by stabilizing the resting state of the hERG channel.

The paper shows that FOXP1 reduces intrinsic excitability in D2 striatal projection neurons by increasing potassium currents through transcriptional activation of KIR and KLeak channels.

The paper identifies cryptic prokaryotic promoters causing instability of human NaV channel cDNA in bacteria and presents stabilized plasmids for functional expression.

The paper investigates the role of ATP-sensitive K+ channels in controlling spontaneous firing of glycinergic cartwheel neurons in the auditory brainstem and links their activity to tinnitus-related hyperactivity.

The paper develops and validates AK-42, a potent and specific inhibitor of CLC-2 chloride channels with nanomolar potency and high selectivity.

This study shows that photoperiod affects TREK-1 channel function and expression in dorsal raphe serotonergic neurons, influencing their excitability.

This study identifies ZDHHC14 as a neuronal palmitoyl acyltransferase that regulates PSD93 and Kv1 channel clustering at the axon initial segment, affecting neuronal excitability.

The paper identifies a persistent potassium current (IM) that interacts with the persistent sodium current (INaP) to regulate locomotion speed in neonatal rodents.