Attention Deficit Hyperactivity Disorder

Investigating causal pathways between liability to ADHD and substance use, and liability to substance use and ADHD risk, using Mendelian randomization.

This study uses Mendelian randomization to investigate bidirectional causal relationships between ADHD liability and substance use, finding evidence of causal effects in both directions for smoking and cannabis use.

Altered brain morphology in boys with attention-deficit/hyperactivity disorder with and without comorbid conduct disorder/oppositional defiant disorder

The paper compares brain morphology between ADHD-only and ADHD with comorbid ODD/CD, finding shared and distinct structural differences.

The Role of Gene Encoding Variation of DRD4 in the Relationship between Inattention and Seasonal Daylight

The paper investigates how genetic variation in DRD4 interacts with seasonal daylight changes to influence inattention, finding support for the Spring-focus hypothesis and seasonal patterns in ADHD-related symptoms.

ADHD symptoms map onto noise-driven structure-function decoupling between hub and peripheral brain regions

The paper identifies reduced structure-function coupling in ADHD, linking it to increased neural noise variability in fronto-parietal networks.

The Positive End of the Polygenic Score Distribution for ADHD: A Low Risk or a Protective Factor?

The paper investigates the functional outcomes associated with low ADHD polygenic scores, finding lower ADHD risk and better cognitive and health outcomes in individuals with the lowest scores.

Hyperactive/impulsive and inattention symptoms are associated with reduced ERP activity during different reward processing stages: Evidence from the electrophysiological Monetary Incentive Delay Task in adult ADHD

Identification of risk variants and characterization of the polygenic architecture of disruptive behavior disorders in the context of ADHD

This study identifies risk variants and characterizes the polygenic architecture of ADHD comorbid with disruptive behavior disorders through a large GWAS meta-analysis.

Exploring Genetic Variation That Influences Brain Methylation In Attention-Deficit/Hyperactivity Disorder

This study identifies three novel genes associated with ADHD by linking genetic variants to differential DNA methylation and gene expression in brain tissues.

Transcriptome-wide association study of attention deficit hyperactivity disorder identifies associated genes and phenotypes

This study performs a transcriptome-wide association study (TWAS) of ADHD, identifying 9 significant hits and linking them to dopaminergic and norepinephrine pathways, as well as several phenotypes.

From rare Copy Number Variations to biological processes in ADHD

This study identifies high-priority ADHD candidate genes by integrating rare CNV data with bioinformatics methods and finds shared genes with common variants.

Cross-disorder GWAS meta-analysis for Attention Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Obsessive Compulsive Disorder, and Tourette Syndrome

This study performs a cross-disorder GWAS meta-analysis of ADHD, ASD, OCD, and TS, identifying 297 genome-wide significant variants and 21 genes associated with shared genetic risk.

Identifying novel subtypes of irritability using a developmental genetic approach

This paper identifies five irritability trajectory classes in a longitudinal cohort, linking early-onset patterns to ADHD and late-onset patterns to depression, suggesting distinct developmental origins.

Subcortical brain volume, regional cortical thickness and cortical surface area across attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), and obsessive-compulsive disorder (OCD): findings from the ENIGMA-ADHD, -ASD, and -OCD working groups

This study compares structural brain differences across ADHD, ASD, and OCD using MRI data from multiple cohorts, finding disorder-specific alterations in brain volume and cortical thickness.

Spatial organization of cells and variable expression of autophagy, apoptosis, and neurodevelopmental genes might underlie selective brain region vulnerability in Attention-Deficit/Hyperactivity Disorder

The paper investigates selective brain region vulnerability in ADHD by analyzing gene expression, cell abundance, and brain size changes using imaging and postmortem data.

Resting Eyes Closed Beta-Phase High Gamma-Amplitude Coupling Deficits in Children with Attention Deficit Hyperactivity Disorder

The paper identifies beta-gamma phase-amplitude coupling deficits in ADHD children using EEG data during resting eyes closed state.

Symptom Severity in Youths with Attention Deficit Hyperactivity Disorder Associated with Normalizing Effects of Treatment on fMRI Response during a Stop Signal Task

The paper examines neural correlates of response inhibition in ADHD youths using fMRI and finds that symptom severity is linked to treatment-induced changes in prefrontal BOLD signal.

Genetic markers of ADHD-related variations in intracranial volume

The paper identifies genetic correlations between ADHD and brain volumes, finding negative associations with intracranial volume and specific brain regions.

Disrupted reinforcement learning during post-error slowing in ADHD

This study investigates reinforcement learning in ADHD using fMRI, finding altered neural correlates of error processing and dopamine regulation in ADHD compared to typically developing adolescents.

Disentangling genetically confounded polygenic associations between Attention-Deficit/Hyperactivity Disorder, literacy and language

The paper investigates polygenic associations between ADHD and literacy/language abilities, finding that genetic confounding with educational attainment masks ADHD-specific reading impairments.

ADHD Symptoms are Associated with the Modular Structure of Intrinsic Brain Networks in a Representative Sample of Healthy Adults

The paper examines associations between ADHD symptoms and brain network structure in healthy adults, finding significant links between symptoms and connectivity patterns in key brain networks.

Discovery Of The First Genome-Wide Significant Risk Loci For ADHD

Genome-wide association meta-analysis of 20,183 ADHD cases and 35,191 controls finds 12 significant loci; signal concentrates in conserved regions, constrained genes, and CNS regulatory elements.

ADHD: relation between cognitive characteristics and DAT1 / DRD4 dopamine polymorphisms

The paper examines the association between ADHD and dopamine gene polymorphisms, finding no significant direct link but suggesting a potential risk for cognitive performance traits.

Estimating the Biological Validity of the DSM for Attention Deficit/Hyperactivity Disorder Using Multivariate Analysis for Small Samples

The paper uses multivariate analysis on small ADHD samples to assess DSM validity, finding substantial agreement between DSM classification and neurophysiological data.

Reduced Medial Frontal Positivity During the Stimulus-Response Interval Precedes Action Errors and Explains Task Deficits in Attention-Deficit Hyperactivity Disorder

The paper examines ERP amplitudes during the stimulus-response interval in ADHD adolescents, finding reduced PMP amplitudes predict motor errors and task deficits.

Utility of the SWAN Scale for ADHD Trait-Based Genetic Research: A Validity and Polygenic Risk Study

The paper validates the SWAN Scale as a tool for ADHD trait-based genetic research, showing it predicts ADHD diagnoses and is linked to ADHD polygenic risk.

A low-level perceptual correlate of behavioral and clinical deficits in ADHD

This study dissociates perceptual and executive deficits in ADHD using a task that varies low-level stimulus features and measures task-irrelevant motor output, finding higher perceptual variability and TIMO in ADHD participants.

Atypical functional connectivity in adolescents and adults with persistent and remitted ADHD

The paper examines functional connectivity differences in adolescents and adults with persistent and remitted ADHD compared to controls using EEG and graph-theory metrics.

The contribution of common genetic risk variants for ADHD to a general factor of childhood psychopathology

This study evaluates ADHD genetic risk variants' association with general psychopathology and specific neurodevelopmental traits, finding general pleiotropy and a specific link to hyperactivity/impulsivity.

Brain-behavior patterns define a dimensional biotype in medication-naïve adults with attention-deficit hyperactivity disorder

The paper identifies a dimensional biotype in medication-naïve adults with ADHD using brain-behavior patterns from functional connectivity and symptom correlations.

A genetic investigation of sex bias in the prevalence of attention deficit hyperactivity disorder

This study investigates genetic mechanisms underlying sex bias in ADHD prevalence using genome-wide data and finds no mean polygenic burden difference across sexes but increased risk in female siblings and comorbid conditions.