Cancer-related Molecular Pathways

Oncogenic alterations in the p53 pathway abolish oscillatory competence

The paper shows that oncogenic alterations in the p53 pathway eliminate p53 oscillations, impairing its tumor suppressor function across various cancers.

The research progress of p53 tumour suppressor activity controlled by Numb in triple-negative breast cancer

This study investigates Numb's role in regulating p53 activity in triple-negative breast cancer, showing Numb promotes p53 stability and is associated with lower Ki67 levels.

Frequency switching between oscillatory homeostats and the regulation of p53

The paper examines how p53 regulation shifts between oscillatory and non-oscillatory states in response to DNA damage, highlighting the roles of Per2, ATM, and Mdm2 in maintaining homeostasis.

The TRF2 General Transcription Factor Is a Key Regulator of Cell Cycle Progression

This study identifies TRF2 as a key regulator of cell cycle progression in Drosophila cells, showing its role in controlling cyclin expression and interacting with co-factors GFZF and M1BP.

p53-induced apoptosis is specified by a translation program regulated by PCBP2 and DHX30.

This study identifies a translational control mechanism regulated by PCBP2 and DHX30 that determines the outcome of p53 activation by Nutlin, shifting the response from cell cycle arrest to apoptosis.

Locally acting transcription factors are required for p53-dependent cis-regulatory element activity

The paper investigates how local transcription factors influence p53-bound cis-regulatory elements, showing that co-regulatory factors and sequence context affect CRE activity and gene expression.

Identification of universal and cell type specific p53 DNA binding

The paper identifies universal and cell type specific p53 DNA binding sites by analyzing 12 epithelial cell lines after ionizing radiation.

MXD/MIZ1 complexes activate transcription of MYC-repressed genes

The paper shows that MXD proteins can activate transcription of MYC-repressed genes through interaction with MIZ1 and a functional DNA binding domain, revealing reciprocal antagonism between MXD and MYC in gene regulation.

Diversification of retinoblastoma protein function associated with cis and trans adaptations

This study investigates the functional diversification of retinoblastoma proteins in Drosophila, showing that Rbf2 regulates distinct gene sets and has specialized roles in reproductive development.

Cell type-dependent control of p53 transcription and enhancer activity by p63

The paper shows that p53's transcriptional activity varies by cell type and is influenced by p63's role in enhancer binding and maintenance in epithelial cells.

Comparison of genotoxic vs. non-genotoxic stabilization of p53 provides insight into parallel stress-responsive transcriptional networks

The paper compares genotoxic and non-genotoxic p53 activation in human fibroblasts, showing similar genome-wide binding and chromatin changes but distinct inflammatory gene expression patterns.

Cyclin A2/Cdk1 is Essential for the in vivo S Phase Entry by Phosphorylating Top2a.

This study shows that Cdk1 interacts with Cyclin A2 to phosphorylate Top2a, enabling S phase entry, and with Cyclin B1 to regulate M phase progression in zebrafish embryos.

Variable sensitivity to DNA damaging chemotherapeutic modulated by cell type-dependent bimodal p53 dynamics

This study identifies bimodal p53 dynamics as a mechanism modulating resistance to DNA damaging chemotherapy, showing that ATM expression determines sensitivity and that inhibiting Mdm2 and Wip1 can sensitize resistant cells.

Transcriptome Profiling Reveals Inhibitory Effect of Down-regulated ZBTB38 gene on the Transcriptional Regulation of Tumor Cells Proliferation

The paper identifies 2,438 differentially expressed genes in ZBTB38-knockout SH-SY5Y cells, showing ZBTB38 inhibits tumor cell proliferation by regulating cell cycle arrest and autophagy suppression.

The RASSF6 tumor suppressor protein regulates apoptosis and cell cycle progression via Retinoblastoma protein.

This study identifies RASSF6 as a tumor suppressor that regulates apoptosis and cell cycle progression through pRb, independent of p53.

The Wild-type and Gain-of-function Mutant p53 Enhance p300 Autoacetylation through Conformational Switching

This study shows that p53 enhances p300 autoacetylation through structural changes, which is critical for gene regulation and may be targeted to treat tumors.

TP53 Intron Derived Concentrations Implicate p53

The paper investigates TP53 intronic half-sites and their potential role in p53 regulation across multiple genes.

HMGA1 zebrafish co-orthologue hmga1b can modulate p53-dependent cellular responses but is unable to control the alternative splicing of psen1

The paper shows that hmga1b in zebrafish can modulate p53-dependent cellular responses but not alternative splicing of psen1, similar to hmga1a.