Cancer-related Molecular Pathways

Identify Non-Mutational p53 Functional Deficiency in Human Cancers

The paper identifies non-mutational p53 functional deficiency in TP53 wild-type tumors using SVM models, revealing significant functional impairment and clinical implications.

Stabilization of GTSE1 by cyclin D1-CDK4/6 promotes cell proliferation: relevance in cancer prognosis

The paper shows cyclin D1-CDK4/6 stabilizes GTSE1, promoting cell proliferation and poor cancer prognosis.

p53 Regulates Nuclear Architecture to Reduce Carcinogen Sensitivity and Mutagenic Potential

The paper shows p53 maintains nuclear architecture to reduce carcinogen sensitivity and mutagenic potential by altering chromatin structure and UV lesion abundance.

Basal p53 activity is differentially impacted by individual mutations, defining the immediate response to genotoxicity

The paper examines how different p53 mutations affect basal p53 activity and cellular response to genotoxicity in breast cancer cell lines.

GRK2-mediated AKT activation controls cell cycle progression and G2-checkpoint in a p53-dependent manner

This study identifies GRK2's role in regulating AKT activation during the G2/M transition, showing its dependence on p53 for checkpoint control and tumor cell survival.

Evidences of an inhibitory effect and other functions of human P53 in Escherichia coli

This study shows that human P53 inhibits Escherichia coli cell viability when expressed, with effects observed under normal and stressful conditions, including phage infection and antibiotic treatment.

Basal p53 maintains a distinct transcriptional program from irradiated p53 in tissue, including tumor suppressors

This study defines the murine basal p53 epigenome and transcriptional program in normal tissues, showing it regulates tumor suppressors distinct from the DNA damage response.

Functional consequences of a p53-MDM2-p21 incoherent feedforward loop

The paper investigates how p21 transcription variability arises through an incoherent feedforward loop involving p53 and MDM2, showing it enables rapid p21 induction and treatment-tolerant cell states.

Tumor suppressor p73 transcriptionally regulates c-FLIP to impede its priming of extrinsic apoptosis while a switcher compound degrades c-FLIP protein

This study shows p73 upregulates c-FLIP to suppress extrinsic apoptosis, and a compound degrades c-FLIP to enhance p73's antitumor effects in p53-mutant cancers.

Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogaster

The paper identifies seven genes in Drosophila melanogaster that suppress p53-induced apoptosis through insertional mutagenesis using the DEP transposon.

Conservation of affinity rather than sequence underlies a dynamic evolution of the motif-mediated p53/MDM2 interaction in teleosts

The paper investigates the evolution of p53/MDM2 interaction in teleosts, finding that affinity is conserved through compensatory changes in both conserved and non-conserved regions.

A systematic approach identifies p53-DREAM target genes associated with blood or brain abnormalities

The paper identifies 151 p53-DREAM target genes associated with blood or brain abnormalities through transcriptomic analysis and ChIP-seq data.

Cell cycle progression mechanisms: slower cyclin-D/CDK4 activation and faster cyclin-E/CDK2

The paper investigates why cyclin-D/CDK4 drives the longer G1 phase while cyclin-E/CDK2 regulates the short G1/S transition, proposing slower activation for cyclin-D/CDK4 and faster for cyclin-E/CDK2, with implications for CDK4 inhibitor design.

Shared gene targets of the ATF4 and p53 transcriptional networks

This study identifies shared gene targets regulated by p53 and ATF4, revealing convergent mechanisms in metabolic and pro-apoptotic gene control.

Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness

This study identifies how specific cell cycle checkpoint kinase dysregulations influence cancer subtype, metastasis, and treatment response in breast cancer.

Evolution of affinity between p53 and MDM2 across the animal kingdom demonstrates high plasticity of motif-mediated interactions

The paper examines the evolution of p53/MDM2 interaction affinity across species, finding significant variation in binding strength and suggesting plasticity in motif-mediated interactions.

Prevalence, causes and impact of TP53-loss phenocopying events in human tumors

The paper estimates the prevalence of TP53-loss phenocopying events in tumors and identifies new genes like USP28 and CNOT2 that contribute to p53 pathway inactivation without TP53 mutations.

Multi-omics analysis identifies RFX7 targets involved in tumor suppression and neuronal processes

The paper identifies RFX7 target genes through multi-omics analysis, revealing their role in tumor suppression and neuronal processes.

Reversal of drug resistance by disruption of a Gain-of-Function mutant p53 and transcriptional co-activator PC4 interaction

This study shows that disrupting the interaction between PC4 and the gain-of-function p53 mutant R273H reduces drug resistance by lowering MDR1 expression.

DREAM Interrupted: Severing LIN-35-MuvB association in Caenorhabditis elegans impairs DREAM function but not its chromatin localization

This study shows that disrupting LIN-35-MuvB interaction in C. elegans impairs DREAM function but not chromatin localization, with limited target gene upregulation compared to LIN-35 loss.

Single-cell transitional dynamics unravel stimulus- and cell type-dependent signaling outputs of distinct p53 regulatory feedback motifs

The paper uses single-cell imaging and mathematical modeling to analyze p53 pathway dynamics in response to chemotherapeutics, identifying novel feedback motifs and their role in context-specific signaling responses.

Cell cycle progression requires repression by Groucho during S-phase and its relief at G2-phase

This study shows Groucho represses e2f1 during S-phase and its phosphorylation by Cdk1 relieves this repression at G2-phase, preventing cell cycle arrest.

p53-mediated neurodegeneration in the absence of the nuclear protein Akirin2

This study shows that Akirin2 loss in excitatory cortical neurons leads to neurodegeneration via p53 activation, highlighting its role in neuronal maintenance and potential relevance to neurodegenerative diseases.

TargetGeneReg 2.0: a comprehensive web-atlas for p53, p63, and cell cycle-dependent gene regulation

TargetGeneReg 2.0 expands its database to include non-coding genes and new transcription factors, enabling analysis of gene regulation by p53, ΔNp63, and cell cycle signaling.

Drosophila p53 isoforms have overlapping and distinct functions in germline genome integrity and oocyte quality control.

This study identifies distinct functions of Drosophila p53 isoforms in germline genome integrity and oocyte quality control, showing p53A mediates apoptosis and p53B is involved in DNA break repair.

Computational Model of G2-M DNA Damage Checkpoint Regulation in Normal and p53-null Cancer Cells

The paper was withdrawn due to authorship disputes and is not intended for citation.

Long-term p21 and p53 trends regulate the frequency of mitosis events and cell cycle arrest

The paper analyzes two single-cell datasets to study how p21 and p53 dynamics influence cell cycle arrest and mitosis frequency after radiation exposure.

Transcription factor RFX7 governs a tumor suppressor network in response to p53 and stress

This study identifies RFX7 as a p53-regulated tumor suppressor that activates key genes involved in cell differentiation and apoptosis in response to stress.

Differential chromatin accessibility landscape of gain-of-function mutant p53 tumours

The paper identifies differentially accessible chromatin regions in mutant p53 tumours compared to wild-type p53 tumours in breast and colon cancers, revealing distinct transcription factor enrichments.

p53 pro-apoptotic activity is regulated by the G2/M promoting factor Cdk1 in response to DNA damage

This study shows that Drosophila p53 pro-apoptotic activity is regulated by Cdk1, linking cell cycle status to DNA damage response.