Spinal Cord Injury Research

Neuromechanical strategies for obstacle negotiation during overground locomotion following an incomplete spinal cord injury in adult cats

This study examines how adult cats negotiate obstacles after spinal cord injury, finding improved clearance over time with changes in muscle activation and weight distribution.

Reorganization of corticospinal projections after prominent recovery of finger dexterity from partial spinal cord injury in macaque monkeys

This study examines CST reorganization in macaques after partial spinal cord injury, showing axonal sprouting and re-direction in both rostral and caudal spinal segments contributing to recovery of finger dexterity.

Elevation of NAD+ by nicotinamide riboside spares spinal cord tissue from injury and promotes locomotor recovery

This study shows that nicotinamide riboside (NR) increases NAD+ levels in the injured spinal cord, protecting tissue and improving locomotor recovery in rats.

Functional Trajectories during innate spinal cord repair

The paper tracks functional recovery in zebrafish after spinal cord injury and identifies gait quality as a predictor of regeneration outcomes.

Enhanced selectivity of transcutaneous spinal cord stimulation by multielectrode configuration

This study shows that multielectrode configurations of transcutaneous spinal cord stimulation improve muscle recruitment selectivity by targeting specific spinal segments.

Uncovering and exploiting the return of voluntary motor programs after paralysis using a bi-cortical neuroprosthesis

This study uses a bi-cortical neuroprosthesis to investigate motor program recovery after spinal cord injury in cats, showing that cortical control can be re-established to modulate gait and alleviate foot drag.

Emergent epileptiform activity drives spinal sensory circuits to generate ectopic bursting in intraspinal afferent axons after cord injury

This study shows that spinal cord injury leads to epileptiform activity in sensory circuits, causing ectopic bursting in afferent axons and disrupting sensory signaling.

Spinal facilitation of descending motor input

The paper demonstrates that dynamic spinal stimulation enhances corticospinal motor responses by increasing spinal interneuron excitability, even after injury.

Targeting the Microbiome to Improve Gut Health and Breathing Function After Spinal Cord Injury

This paper shows that probiotic treatment after spinal cord injury improves gut health and respiratory function by reducing inflammation and enhancing neuronal regeneration.

The Tabulae Paralytica: Multimodal single-cell and spatial atlases of spinal cord injury

The paper introduces the Tabulae Paralytica, a multimodal atlas of spinal cord injury, revealing biological principles and developing a gene therapy to restore walking in old mice.

A novel therapeutic approach of ultrasound stimulation to restore forelimb functions following cervical cord injury in rats

This study investigates the effects of low-intensity pulsed ultrasound (LIPUS) on forelimb function recovery in rats with cervical cord injury, showing improved performance with combined LIPUS and Buspirone treatment.

Boldine modulates glial transcription and functional recovery in a murine model of contusion spinal cord injury

Boldine improves locomotor function and reduces glial activation in a mouse model of spinal cord injury by modulating calcium signaling and gene expression.

Spinal sensorimotor circuits play a prominent role in hindlimb locomotor recovery after staggered thoracic lateral hemisections but cannot restore posture and interlimb coordination during quadrupedal locomotion in adult cats

Relating spinal injury-induced neuropathic pain and spontaneous afferent activity to sleep and respiratory dysfunction

Transplanted Autologous Neural Stem Cells Show Promise in Restoring Motor Function in Monkey Spinal Cord Injury

This study transplants autologous neural stem cells into Rhesus monkeys with spinal cord injury, showing functional and structural recovery without adverse effects.

Therapeutic administration of mouse mast cell protease 6 improves functional recovery after traumatic spinal cord injury in mice by promoting remyelination and reducing glial scar formation

This study shows that administering recombinant mouse mast cell protease 6 improves functional recovery after spinal cord injury by reducing demyelination and astrogliosis.

Motor-targeted spinal stimulation promotes concurrent rebalancing of pathologic nociceptive transmission in chronic spinal cord injury

This study shows motor-targeted spinal stimulation can reduce neuropathic pain by decreasing activity in pain pathways while preserving motor function in chronic spinal cord injury.

Global disinhibition and corticospinal plasticity for drastic recovery after spinal cord injury

This study shows that global disinhibition and corticospinal plasticity enable drastic motor recovery after spinal cord injury in macaques through intensive training and cortical electrical stimulation.

Oral administration of 4-methylumbelliferone reduces glial scar and promotes anatomical plasticity

This study evaluates the effect of 4-MU on spinal cord injury in rats, showing reduced HA synthesis and glial scar but insufficient functional recovery.

The neuroprotective effects of estrogen and estrogenic compounds in spinal cord injury

This review evaluates estrogen and estrogenic compounds' neuroprotective effects in spinal cord injury, finding they reduce inflammation and improve functional outcomes.

Single-cell sequencing for the molecular identity involved in zinc therapy for spinal cord injury

This study uses single-cell sequencing to analyze the transcriptomic changes in mice with spinal cord injury treated with zinc therapy, identifying immune heterogeneity and potential mechanisms of neuroprotection.

The study of fibrotic scar at the long term spinal cord lesion rats

The paper investigates fibrotic scar formation in spinal cord lesion rats over one year and assesses neuronal regeneration through fore paw reaching task performance.

Delayed viral vector mediated delivery of neurotrophin-3 improves skilled hindlimb function and stability after thoracic contusion in rats

This study shows that delayed AAV1-NT3 injection after spinal injury improves skilled locomotion and swimming coordination in rats but not gross movement.

Tuning of motor outputs produced by spinal stimulation during voluntary control of torque directions in monkeys

This study shows spinal stimulation enhances or suppresses muscle activity during voluntary torque tasks in monkeys, depending on torque direction and voluntary muscle activity levels.

Single Cell Profiling of CD45+ Spinal Cord Cells Reveals Microglial and B Cell Heterogeneity and Crosstalk Following Spinal Cord Injury

The paper uses single-cell RNA sequencing to identify immune cell populations and interactions in mouse spinal cord injury, revealing microglial and B cell heterogeneity and crosstalk.

Spatiotemporal orchestration of multicellular transcriptional programs and communications in the early stage of spinal cord injury

The paper maps the spatiotemporal gene expression and cell-cell interactions in a mouse model of acute spinal cord injury, identifying key molecular features and cell types involved in early injury response and recovery.

Serotonergic Modulation of Spinal Circuitry Restores Motor Function after Chronic Spinal Cord Injury

This study combines serotonergic agonist delivery with rehabilitation to improve motor recovery in severely injured rats, showing long-term benefits after treatment cessation.

Does Functional Recovery Imply Stable Circuitry in the Spinal Animal?

This study uses computer simulations to investigate whether gait training in spinalized rats leads to stable spinal circuitry recovery, finding that both stabilizing and destabilizing learning strategies result in functional recovery but not necessarily stable circuitry.

Open spaced ridged hydrogel scaffolds containing TiSAMP surface chemistry promotes regeneration and recovery following spinal cord injury.

This study develops a hydrogel scaffold with surface chemistry that promotes axon outgrowth and hindlimb recovery in spinal cord injury models.

High-Frequency Stimulation Does Not Improve Comfort of Transcutaneous Spinal Cord Stimulation

This study investigates whether high-frequency transcutaneous spinal cord stimulation (tSCS) is more comfortable than conventional tSCS at therapeutic amplitudes, finding no significant difference in discomfort ratings.