Spinal Cord Injury Research

A NEW POSTURAL MOTOR RESPONSE TO SPINAL CORD STIMULATION: POST-STIMULATION REBOUND EXTENSION

This study identifies and characterizes a new postural motor response to spinal cord stimulation called LEAP, which has potential for clinical applications in motor disorders.

Transcriptomic analysis identifies injury-responsive fibroblast populations as potential mediators of Wnt-dependent spinal cord regeneration

The paper identifies injury-responsive fibroblast populations and Wnt-regulated genes in zebrafish spinal cord injury using bulk RNA-seq.

Glycolytic metabolism modulation on spinal neuroinflammation and vital functions following cervical spinal cord injury

This study investigates the effects of 2-DG on spinal neuroinflammation and respiratory function after cervical spinal cord injury in rats, finding no effect on injured rats but adverse effects in sham animals.

THE NEURONAL ARCHITECTURE OF AUTONOMIC DYSREFLEXIA

This study identifies neuronal architectures responsible for autonomic dysreflexia after spinal cord injury and demonstrates how epidural stimulation can counteract it in mice, rats, and humans.

Lesion-induced impairment of therapeutic capacities of olfactory ensheathing cells in an autologous transplantation model for treatment of spinal cord injury

The paper shows that spinal cord injury impairs the therapeutic potential of olfactory ensheathing cells used in autologous transplantation.

Long-term mouse spinal cord organotypic slice culture as a platform for validating cell transplantation in spinal cord injury

This paper describes an optimized protocol for long-term maintenance of mouse spinal cord organotypic slices transplanted with human neural stem cells to test cell replacement therapies for spinal cord injury.

Changes in intra- and interlimb reflexes from hindlimb cutaneous afferents after staggered thoracic lateral hemisections during locomotion in cats

This study examines how spinal cord injuries affect cutaneous reflexes and interlimb coordination during locomotion in cats, finding reduced mid- and long-latency reflex responses correlate with impaired balance and coordination.

Distinct Motor Map Characteristics for Biceps and Triceps Muscles in Persons with Chronic Tetraplegia: Implications for Arm Function

This study compares motor map characteristics between biceps and triceps muscles in individuals with chronic tetraplegia and able-bodied controls, finding hyper-excitability in biceps maps associated with motor function.

Challenges and Efficacy of Astrocyte-to-Neuron Reprogramming in Spinal Cord Injury: In Vitro Insights and In Vivo Outcomes

This study investigates the reprogramming of astrocytes to neurons in spinal cord injury, showing higher in vitro efficiency than in vivo.

Brain activation during the N-back working memory task in individuals with spinal cord injury: a functional near-infrared spectroscopy study

This study uses fNIRS to examine brain activation during an N-back task in individuals with spinal cord injury compared to able-bodied controls, finding hemodynamic differences despite similar task performance.

A spinal cord injury time and severity consensus transcriptomic reference suite in rat reveals translationally-relevant biomarker genes

This study identifies severity- and phase-specific biomarker genes for spinal cord injury using transcriptomic analysis and develops a web tool for exploring results.

Reanalysis of published data can help to characterize neuronal death after Spinal Cord Injury

The paper reanalyzes published spinal cord injury data to characterize neuronal death and evaluate neuroprotective effects using new methods and an open repository.

NG2 Glia Reprogramming Induces Robust Axonal Regeneration After Spinal Cord Injury

This study shows that reprogramming NG2 glia after spinal cord injury leads to axonal regeneration and improved function.

Human spinal interneurons repair the injured spinal cord through synaptic integration

This study shows that human cervical V2a interneurons transplanted into injured spinal cords form functional synaptic connections with host tissue, improving diaphragm activity.

PTEN inhibition promotes robust growth of bulbospinal respiratory axons and partial recovery of diaphragm function in a chronic model of cervical contusion spinal cord injury

This study shows that PTEN inhibition promotes partial diaphragm function recovery and axon growth in chronic cervical spinal cord injury, while PTPσ inhibition does not.

STEREOLOGICAL EVALUATION OF TISSUE PRESERVATION AFTERNEUROPROTECTIVE TREATMENTS FOR TRAUMATIC SPINAL CORDINJURY

The paper evaluates the use of stereological tools to assess tissue damage and neurodegeneration after spinal cord injury and tests the efficacy of different therapeutic strategies.

Combining transcutaneous spinal stimulation and functional electrical stimulation increases force generated by lower limbs: When more is more

This study shows that combining transcutaneous spinal stimulation with functional electrical stimulation increases force production in lower limbs, with optimal timing between the two modalities.

Silencing long-descending inter-enlargement propriospinal neurons improves hindlimb stepping after contusive spinal cord injuries

Construction of a searchable database for gene expression changes in spinal cord injury experiments

The paper constructs a searchable database of RNA-Seq data from spinal cord injury experiments to enable cross-study and cross-species analysis.

Intermediate Gray Matter Interneurons in the Lumbar Spinal Cord Play a Critical and Necessary Role in Coordinated Locomotion

This study shows that damaging intermediate gray matter in the lumbar spinal cord of rats causes long-term locomotor deficits, with machine learning confirming the link to interneuronal loss.

The composition of motor recovery revealed by syllable-level behavioral analysis after spinal cord injury

This study uses motion sequencing to analyze behavioral syllables after spinal cord injury, revealing recovery patterns shaped by injury severity and individual differences.

Multi-session transcutaneous spinal cord stimulation prevents chloride homeostasis imbalance and the development of spasticity after spinal cord injury in rat

This study shows that multi-session transcutaneous spinal cord stimulation reduces spasticity and improves motor function in rats with spinal cord injury by preventing chloride homeostasis imbalance.

CD1d-dependent neuroinflammation impairs tissue repair and functional recovery following a spinal cord injury

This study shows CD1d promotes proinflammatory responses after spinal cord injury, impairing tissue repair and functional recovery, and identifies CD1d as a potential therapeutic target.

PTEN deletion in spinal pathways via retrograde transduction with AAV-rg enhances forelimb motor recovery after cervical spinal cord injury; sex differences and late-onset pathophysiologies

This study uses AAV-rg/Cre to delete PTEN in spinal pathway cells after SCI, improving forelimb motor recovery but causing late-onset pathophysiologies in mice.

Effects of dim light at night in C57BL6/J mice on recoveryafter spinal cord injury

This study examines the effects of dim light at night on recovery from spinal cord injury in mice, finding modest impacts on locomotion, pain, and mood-related behaviors.

Recovery of forearm and fine digit function after chronic spinal cord injury by simultaneous blockade of inhibitory matrix CSPG production and the receptor PTPσ.

This study shows that blocking CSPG production and the receptor PTPσ improves functional recovery in chronic spinal cord injury models.

PTEN knockout using retrogradely transported AAVs restores locomotor abilities in both acute and chronic spinal cord injury.

This study shows that PTEN knockout via retrogradely transported AAVs can restore locomotor function in both acute and chronic spinal cord injury, but functional improvements are not sustained long-term.

Spinal cord injury: a systematic review and meta-analysis of microRNA alterations

This study performs a systematic review and meta-analysis of miRNA alterations in spinal cord injury across species, identifying conserved miRNAs involved in pathophysiological processes.

Neural population dynamics reveal that motor-targeted intraspinal microstimulation preferentially depresses nociceptive transmission in spinal cord injury-related neuropathic pain.

This study shows motor-targeted intraspinal microstimulation reduces nociceptive transmission in rats with SCI-related neuropathic pain, similar to intact animals, suggesting potential for multi-modal rehabilitation therapies.

Spinal control of locomotion before and after spinal cord injury

This study examines how spinal cord injury affects locomotion speed and gait in rats, revealing changes in gait patterns and coordination after injury.