Hair Growth and Disorders

Reorganizing Niche Architecture Still Preserves Organ Function in the Hair Follicle

The paper shows that reorganizing the hair follicle niche architecture can still support organ function, though it may lead to premature differentiation and reduced hair production.

Transit-amplifying progenitor with maturation-dependent behavior contributes to epidermal renewal

The paper identifies a class of non-self-renewing epidermal progenitors with bi-phasic and maturation-dependent behavior in vivo.

Epidermal basal domains organization highlights skin robustness to environmental exposure

The paper identifies two basal IFE domains in mouse and human skin that adapt to UV exposure, revealing a novel transcription factor, Sox6, involved in IFE proliferation and survival.

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia

This study shows that deletion of Hif-p4h-2 in FoxD1-lineage mesenchymal cells causes congenital truncal alopecia by disrupting hair follicle development and signaling pathways.

The alopecia areata phenotype is induced by the water avoidance stress test in cchcr1-deficient mice.

The study shows that CCHCR1-deficient mice develop alopecia areata-like hair loss after water avoidance stress, suggesting CCHCR1's role in AA pathogenesis.

Dermal EZH2 simultaneously orchestrates dermal differentiation and epidermal proliferation during murine skin development

This study shows dermal EZH2 coordinates dermal fibroblast differentiation and epidermal proliferation during mouse skin development by regulating Wnt/β-catenin and RA signaling.

Thyroid hormone regulates abrupt skin morphogenesis during zebrafish postembryonic development

This study shows thyroid hormone regulates dermal development and scale formation in zebrafish through nuclear hormone receptors, coupling skin growth with body size.

A single-cell transcriptome atlas during Cashmere goat hair follicle morphogenesis

This study generates a single-cell transcriptome atlas of Cashmere goat hair follicle development, identifying 16 cell clusters and revealing conserved and species-specific developmental programs.

High-throughput phenotyping methods for quantifying hair fiber morphology

The paper introduces a high-throughput method for imaging and analyzing scalp hair morphology and validates a Python package for processing and measuring hair images.

Mapping the molecular and structural specialization of the skin basement membrane for inter-tissue interactions

The paper identifies BM composition and architecture at inter-tissue interfaces in mouse hair follicles, revealing specialized structures for different interactions.

Early mechanisms of whisker development: Prdm1 and its regulation in whisker development and evolutionary loss

This paper investigates the role of Prdm1 in whisker development and its evolutionary loss, showing its regulatory impact on gene expression and neural organization in mice.

Single cell transcriptomics of human epidermis reveals basal stem cell transition states

The paper uses single-cell RNA sequencing to identify spatially distinct basal stem cell populations in human epidermis and shows their role in maintaining epidermal homeostasis through signaling and differentiation.

Transcriptome analysis reveals the genetic basis underlying the development of skin appendages and immunity in hedgehog (Atelerix albiventris)

The paper analyzes the transcriptome of hedgehog skin tissues to identify genes involved in hair and spine development and their immune-related functions.

Werewolf, there wolf: variants in Hairless associated with hypotrichia and roaning in the lykoi cat breed

The paper identifies variants in the Hairless gene associated with hypotrichia and roaning in lykoi cats by comparing whole genome sequencing data from a lykoi cat to a non-lykoi dataset.

SPECIFIC ECTODERMAL ENHANCERS CONTROL THE EXPRESSION OF HoxC GENES IN DEVELOPING MAMMALIAN INTEGUMENTS

This study identifies two mammalian-specific enhancers upstream of the HoxC gene cluster that regulate Hoxc gene expression in ectodermal organs like hair and nails.

In silico analysis of imprinted gene expression in the mouse skin.

The paper analyzes imprinted gene expression in mouse skin, finding elevated expression of 16 IGN genes during telogen and early anagen phases and suggesting they regulate hair cycle-associated genes.

Hair-bearing human skin generated entirely from pluripotent stem cells

Stepwise modulation of TGFβ, BMP, and FGF signaling in human pluripotent stem cell aggregates generates innervated, pigmented hair-bearing skin organoids that form planar human skin when grafted onto nude mice.

Complementary In Vivo Approaches Reveal Quiescent Melanocytes in Anagen Outside the Hair Follicle Bulge

The paper identifies quiescent melanocytes outside the hair follicle bulge during anagen, showing they retain stem cell characteristics similar to quiescent McSCs in telogen.

Molecular Basis of Maintaining Circannual Rhythm in the Skin of Cashmere Goat

The study identifies seasonal rhythm genes (SRGs) in cashmere goat skin that regulate physiological processes in response to photoperiod changes.

Differentiation genes were governed by DNA methylation during hair follicle morphogenesis in Cashmere goat

The paper investigates DNA methylation's role in hair follicle differentiation in cashmere goats, showing gene repression during induction and activation during differentiation, with lncRNAs influencing DNA methylation of key genes.

Dicer- and BSC-dependent miRNAs during murine anagen hair follicle development

The paper investigates the role of Dicer and Tarbp2 in miRNA function within hair follicle bulge stem cells during post-natal anagen development using conditional knockout models.

Single-cell transcriptome profiling reveals dermal and epithelium cell fate decisions during embryonic hair follicle development

The paper uses single-cell RNA sequencing to analyze cell fate decisions in hair follicle development, identifying cell clusters and regulatory factors involved in epithelium and dermal lineage differentiation.

Hair regeneration by small molecules that activate autophagy

The paper identifies small molecules that activate autophagy to stimulate hair regeneration in various conditions.

A direct link between Prss53, hair curvature, and skeletal dysplasia

This study shows that Prss53 loss in rabbits causes curved hair and skeletal dysplasia, with disrupted calcium metabolism implicated in these phenotypes.

Skin transcriptome reveals the Periodic changes in genes underlying hair follicle cycling in Cashmere

The paper analyzes the transcriptome of cashmere goats' skin across different periods to identify genes involved in secondary hair follicle cycling and validates their regulation using fluorescence quantitative PCR.

Fate Before Function: Specification of the Hair Follicle Niche Occurs Prior to its Formation and Is Progenitor Dependent

The paper shows that hair follicle niche precursors are specified before niche formation and requires FGF20 from progenitors.

Hair Follicle Epidermal Stem Cells Define a Niche for Tactile Sensation

The paper identifies a niche of hair follicle epidermal stem cells that support tactile sensation by maintaining stable interfaces with mechanosensory structures.

Divergent genetic mechanisms lead to spiny hair in mammals

This study investigates the genetic basis of spiny hair evolution in rodents, finding that a specific Edar mutation associated with human hair variation is not linked to spiny hair in rodents.

Alopecia areata susceptibility variant identified by MHC risk haplotype sequencing reproduces symptomatic patched hair loss in mice

The paper identifies a susceptibility variant in CCHCR1 associated with alopecia areata and shows its effect in mice with patched hair loss.

Functional mapping of the mouse hairless gene promoter region

The paper identifies a cis-regulatory element in the mouse Hr gene promoter and characterizes its functional motifs involved in gene regulation.