Hair Growth and Disorders

BRN2 suppresses stress-induced hair greying

This study identifies BRN2 as a regulator of melanocyte stem cell resilience under genotoxic stress, showing its role in preventing irradiation-induced hair greying.

BMP6 coordinates dermal papilla and epithelial cell states for hair follicle engineering and regeneration

This study identifies BMP6 as a regulator that maintains dermal papilla function and promotes epithelial differentiation in hair follicle engineering.

Spatiotemporal atlas resolves the mesenchymal-epithelial stem cell axis governing human hair follicle aging and pathology

This study creates a spatiotemporal atlas to understand mesenchymal-epithelial stem cell dynamics in human hair follicle aging and androgenetic alopecia, identifying PTN as a key regenerative factor.

Jag2 patterns early differentiation in the epidermal stem cell layer

The paper shows that stem cells in the epidermis use Jag2 to influence neighboring cell differentiation, maintaining tissue structure and function.

Function-driven geometry directs human pilosebaceous unit development

The paper builds a spatiotemporal map of human pilosebaceous unit development using single-cell multiomics and machine learning, showing how epithelial-mesenchymal interactions drive organogenesis and how sebaceous gland programs are disrupted in tumors.

Sex Differences in Physiological Hair Cycling and Adhesive Material-Induced Hair Regeneration in Mice

This study identifies sex differences in physiological hair cycling and adhesive material-induced hair regeneration in mice, showing male-specific macrophage dependence in regenerative responses.

Regional Differences in Dorsal Skin Determine the Rate of Adhesive Material-Induced Hair Regeneration

The paper shows that hair regeneration after adhesive material application varies by position along the mouse dorsal skin, with earlier regrowth at cranial sites.

Bioelectric state transitions enable de novo feather bud formation in developing skin

The paper shows that perturbing calcium signaling in chicken skin induces de novo feather bud formation, revealing bioelectricity as a regulatory layer in tissue patterning.

Multimodal Human Scalp Atlas Defines Cell Landscape and Lineage Architecture In Situ

The paper creates a multimodal atlas of human scalp tissue, revealing cell states, lineage organization, and disease-specific perturbations in hair loss conditions.

AI-enabled discovery of small molecules targeting complementary pathways for hair follicle rejuvenation

This study uses AI to discover small molecules that rejuvenate hair follicles by targeting complementary pathways, showing increased cell viability and suppression of follicular miniaturization.

The Il1r2-CreERT2 knock-in mouse enables inducible labeling of slow-cycling epidermal basal cells and genetic ablation of the IL-1 decoy receptor

This study identifies Il1r2 as a marker for slow-cycling epidermal basal cells and develops a genetic tool for lineage tracing and IL-1 signaling modulation.

Rete Ridge Topography as a Determinant of Epidermal Stem Cell Identity: Implications for Skin Aging

This study shows that the concave topography of rete ridges influences epidermal stem cell differentiation and function, with changes in topography contributing to skin aging.

Inflammatory IL-1 signaling remodels epidermal stem cell compartments by suppressing Wnt activity

The paper shows that IL-1 signaling suppresses Wnt activity in epidermal stem cells during inflammation, leading to changes in stem cell compartments that can be reversed by Wnt reactivation.

Immune cells adapt to distinct stem cell niches to govern tissue homeostasis

The paper shows how immune cells adapt to different stem cell niches in skin to maintain tissue homeostasis by adjusting their functions based on the niche's specific demands.

Coordinated inhibition of SOX9 and cell cycle progression by microRNA-200 restricts sebaceous gland fate specification

This study shows that miR-200 inhibits SOX9 and cell cycle progression to block sebaceous gland fate specification in hair follicles.

Hair promotion effect of Beta vulgaris L. fruit extracts; physicochemical, and analytical evaluation

This study evaluates the hair growth promotion activity of Beta vulgaris L. extracts in mice, finding that ethanolic extract is more effective than methanolic.

Modeling Oxidative Stress-Linked Telogen Effluvium: A Monte Carlo Simulation Using Published Trichoscopy Norms and Cannabis Exposure Distributions

This paper uses a Monte Carlo simulation to explore correlations between cannabis exposure and hair loss characteristics in a synthetic population.

Crosstalk between Immune Microenvironment and Hair Follicle Cells Underlies Sexual Dimorphism in Androgenetic Alopecia

This study investigates sex-specific differences in androgenetic alopecia by analyzing immune-follicle interactions and identifies potential therapeutic polypeptides.

In Vivo Non-Invasive Observation of Dynamic Changes in Hair Shaft, Melanin, and Collagen During the C57BL/6 Follicle Cycle

This study uses non-invasive methods to monitor hair shaft, melanin, and collagen dynamics in C57BL/6 mice across hair follicle cycles.

Hair Dermal papilla maintain its hair inducing characteristics via autocrine exosomal miR-23a-3p

This study develops a growth model to track hDPC functional recovery and identifies autocrine signaling as critical for maintaining their hair-inductive capacity.

Epidermal γδ T cells, CD8 T cells and macrophages are increased in number in alopecia areata and express BST2 as part of an interferon-driven antiviral gene signature

Heterozygous KRT32 variant is responsible for autosomal dominant loose anagen hair syndrome

The paper identifies a heterozygous KRT32 variant causing autosomal dominant loose anagen hair syndrome and shows it reduces binding affinity to KRT82, impairing hair shaft anchoring.

Rhamnose-mediated modulation of hair follicle growth: insights from chemical genomics

This study identifies rhamnose as a compound that promotes hair follicle growth by restoring hair-inducing gene expression and inducing glucose metabolism remodeling.

Defining epithelial stem cell heterogeneity through undulating structures of the skin and oral mucosa

This study investigates how undulating tissue structures influence epithelial stem cell heterogeneity in skin and oral mucosa using mouse models and 3D culture systems.

Differential Expression of Edar and Xedar During Mouse and Rat Tail Appendage Development

The paper quantifies Edar and Xedar expression in mouse and rat tail appendages during development, revealing species-specific expression patterns linked to hair versus scale formation.

Genetic Characterization of the Cell Types of in Developing Feathers, and the Evolution of Feather Complexity

The paper characterizes feather cell types in developing chicken embryos using single-cell RNA sequencing and identifies a new cell type, while analyzing their evolutionary relationships.

New technologies for hair follicle growth and regeneration: comparison between different commercial products contain exosomes

The paper compares two exosome-based products for hair follicle regeneration, finding that bovine colostrum-derived exosomes promote dermal papilla growth better than umbilical cord stem cell-derived exosomes.

Nitrate Promoting Hair Growth Through Enhancing Wnt/β-catenin and Downregulating TGF-β/Samd/BMP signaling pathway in C57BL/6 Mice

This study shows nitrate promotes hair growth in mice by enhancing Wnt/β-catenin signaling and reducing TGF-β1/Smad/BMP pathway activity.

ARHGEF3 Regulates Hair Follicle Morphogenesis

This study identifies ARHGEF3 as a regulator of hair follicle morphogenesis by promoting cell shape rearrangements during placode formation in mice.

Wound-initiated hair regeneration by adhesive and shrinkable materials

This study shows that inducing epidermal regeneration through adhesive and shrinkable materials can trigger hair follicle neogenesis in mice, regardless of age or sex, leading to synchronized hair growth.