Neuroinflammation and Neurodegeneration Mechanisms

The paper compares two iPSC-microglia protocols to assess how the MAPT-S305N mutation affects microglial function and neuronal health in a frontotemporal dementia model.

The paper uses CRISPR mapping to identify pharmacological targets for modulating microglial migration linked to Alzheimer's disease.

This study identifies a nuclear function of Cx43 in microglia that restricts neurotoxicity during brain development, revealing a channel-independent mechanism involving transcriptional regulation.

The paper identifies heterogeneous and dynamic gene expression in macrophage subpopulations during zebrafish spinal cord regeneration.

This study shows that STING inhibits microglial phagocytosis and protects neurons during epileptogenesis by regulating calcium signaling through the STING-STIM1-SOCE axis.

This study shows that blocking fibrin-induced microglia activation reduces neuronal hyperactivity and restores the neuroimmune interactome in Alzheimer's disease.

A microglia-targeted MRI probe distinguishes Parkinsonian mice from controls by generating disease-specific contrast through radiomics analysis.

This study identifies APOE4/4-driven dysfunctional microglial states in Alzheimer's disease through multiomic analysis, revealing shifts toward terminal states with metabolic disruption and inflammatory signaling.

This study investigates how GPCR signaling pathways modulate TNF production in glial cells, finding that Gs and Gq pathways reduce TNF while Gi increases it.

This study shows that microglial CSF1R signaling is required for stress-induced MMP-2/9 activity in the nucleus accumbens core.

This study uses spatial transcriptomics to show that immune checkpoint inhibitors activate microglia via T cell interactions, leading to neuroinflammation and synaptic dysfunction in the brain.

The paper compares senescent and reactive astrocytes, finding distinct gene expression profiles and functional capacities, with senescent astrocytes supporting neurite outgrowth while reactive astrocytes do not.

This study shows that PLCγ-dependent phosphoinositide turnover regulates Draper-mediated glial engulfment in Drosophila, linking PLCG2 to neurodegenerative disease risk.

This paper uses multi-omic profiling in a mouse stroke model to show that host and microbial changes converge around day 7 post-injury.

The paper shows that inflammatory stimulation leads to a persistent C3-high astrocyte state after stimulus removal, which is reduced by JAK inhibition.

This study shows that neuronal UBE3A loss triggers a TNF-driven neuron-to-microglia signaling axis that promotes synapse remodeling and microglial inflammation.

This study shows that NOD2 activation with MDP during ZIKV infection shifts monocytes to an anti-inflammatory state, preserving synapses and cognitive function in the hippocampus.

This study uses somatic mutations to track marrow-derived cell infiltration into the human brain, finding widespread microglia replenishment and a protective link between clonal hematopoiesis and Alzheimer's disease.

This study investigates how Inflamate(R) affects LPS-induced inflammation and iron dysregulation in astrocytes, showing reduced pro-inflammatory gene expression and promotion of neuroprotective A2 polarization.

This study develops an organotypic neocortical slice culture to study neuroglial interactions across development and disease states.

This study validates 5-MOP as a highly selective CSF1R radioligand with nanomolar affinity, enabling accurate detection of drug occupancy and microglial activation.

This study shows that APOE4 impairs lipoprotein secretion in microglia, leading to lysosomal and mitochondrial dysfunction and a proinflammatory phenotype.

This study identifies dual-phenotype microglia (DPM) with oligodendrocyte-like features using single-cell transcriptomics and shows their distinct roles in brain health and disease.

This study investigates how microglia antigen presentation via MHC class I alleles affects CD8 T cell responses and BBB integrity during neurotropic virus infection.

This study shows that the APOE4 allele increases microglial vulnerability to arsenite exposure through transcriptional and functional changes.

This study uses 3D cortical microtissues to monitor microglia dynamics across maturation and inflammatory responses, showing changes in morphology, surveillance, and injury response.

This study shows that soluble TREM2 reduces DAP12 surface expression by dissociating the TREM2-DAP12 complex, thereby inhibiting microglial phagocytosis and amyloid-β incorporation.

The paper identifies a microglial gene program linked to dyskinesia in Parkinson's disease and shows that sTREM2 reduces dyskinesia by modulating TrkB signaling and synaptic plasticity.

The paper shows microglia preserve fear memory by selectively pruning extinction-ensemble synapses through local signaling cues during memory retrieval.

This study shows that ApoE4 lipidation state affects human microglial metabolism and function, with lipid-bound ApoE4 causing metabolic reprogramming and lipid-free ApoE4 inducing inflammatory signaling.