Neuroinflammation and Neurodegeneration Mechanisms

This study identifies a distinct reactive microglial phenotype in human AUD that activates astrocytes, contributing to neurodegeneration and heavy drinking.

This study evaluates hexokinase-2 inhibitors' effects on post-stroke inflammation and neuroprotection, finding that selective inhibitors reduce microglial activation and improve functional outcomes.

The paper identifies a conserved microglial synaptic pruning pathway linked to Alzheimer's disease and epilepsy through genome-wide transcriptomic analysis across multiple models and human cohorts.

This study shows that neutrophils from Alzheimer's Disease mice have impaired phagocytosis and altered immune modulator release, both in young and aged stages.

This study shows that mid-aged mice normalize dysglycemia faster than young mice when reversing obesity, but their hypothalamic microgliosis worsens after diet reversal.

This study examines how HIV and substance use disorders affect gene expression in human ventral midbrain neurons and microglia, identifying transcriptional changes linked to disease comorbidities.

This study examines cytokine gene expression in human brain tissue from elderly individuals with and without Alzheimer's disease to identify biomarkers and understand disease mechanisms.

The paper shows that SCZ astrocytes, when stimulated, induce a dystrophic phenotype in microglial-like cells through altered cytokine profiles and impaired phagocytosis.

This study shows that LRRK2 kinase activity in microglia restricts NRF2-dependent mitochondrial protection, contrasting with its role in peripheral macrophages.

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

The paper characterizes the human microglia responsome by analyzing gene expression in microglia exposed to various stimuli, identifying distinct responses and genetic interactions relevant to disease.

The paper shows that amoeboid microglia engulf oligodendrocyte progenitor cells in the developing cerebellum, with implications for neurodevelopmental disorders.

This study shows microglia instruct astrocyte-synapse interactions via Wnt signaling, enabling microglia to remove synapses during activity-dependent remodeling.

The paper develops a xenotransplantation model to study human microglia's processing of dying neurons, identifying a lipid-rich compartment called the gastrosome involved in neurodegeneration.

This study shows that dopaminergic signaling in adolescence affects microglial behavior and axonal plasticity in the frontal cortex, with potential therapeutic implications for adult brain plasticity.

This study identifies the flexible stalk domain of sTREM2 as critical for differential ligand binding and neuroprotection in Alzheimer's disease through molecular dynamics simulations.

This study shows that microglia prune astrocytic processes in response to high-salt diet, leading to increased neuronal activity and hypertension.

This study investigates how P2RY12 loss affects microglial metabolic and activation states, revealing altered metabolic pathways and increased susceptibility to ferroptosis.

This study investigates how P2Y12 loss affects microglial gene expression, dynamics, and injury response in the cerebellum and cerebral cortex, finding region-specific roles for P2Y12 in injury response and plasticity.

This paper identifies FGA139 as a novel cysteine protease inhibitor with anti-inflammatory and neuroprotective effects, showing it modulates microglial activation through multi-omics profiling.

The paper investigates cell-to-cell communication in Alzheimer's disease to characterize disease biology and suggest new avenues for therapeutic intervention.

This study shows that microglia activate in response to photoreceptor loss in the retina, but neutrophils are not recruited despite their proximity to blood vessels.

This study shows that PU.1 dosage regulates microglia maintenance in zebrafish and mammals through cell competition and apoptosis.

This study shows that astrocytic RIPK3 reduces inflammation in viral encephalitis by increasing serpin protease inhibitors, improving survival and BBB integrity.

This study examines microglial dynamics across different life stages, showing significant morphological and functional changes in response to injury.

This study shows that triglyceride metabolism is essential for microglial activation and disease states in APOE4 microglia, with implications for modulating immune responses.

This study reprograms human macrophages in vitro using cytokines to mimic Alzheimer's disease-relevant phenotypes, showing transcriptomic and functional changes similar to disease-associated microglia.

This study identifies miRNA expression changes in activated microglia, showing their role in inflammation and potential as biomarkers for neurodegenerative diseases.

This study uses single-cell RNA sequencing to analyze the temporal cellular responses in the brain during HSV-1 infection, identifying distinct immune cell subpopulations and their roles in both protective and pathological processes.

The paper investigates hemodynamic traveling waves in a rat neuroinflammation model, showing their correlation with glial cell reactivity and implications for functional neuroimaging.