Celiac Disease Research and Management

A predisposing effect of HLA class II genes in celiac disease by skewing the naive CD4+ T-cell receptor repertoire

The paper shows HLA-DQ2.5 variants increase frequencies of TCR genes involved in gluten epitope recognition in CeD patients, linking HLA to disease by shaping the naive TCR repertoire.

CLONAL LYMPHOCYTE EXPANSIONS AND JAK-STAT PATHWAY MUTATIONS DEFINE A PATHOGENIC CONTINUUM DRIVING RESISTANCE TO GLUTEN-FREE DIET IN CELIAC DISEASE

This study identifies clonal lymphocyte expansions and JAK-STAT mutations in celiac disease subtypes, revealing shared mechanisms and limitations of JAK inhibitor therapy.

T Cell Receptors for Antigen on Intraepitheial Cytolytic T Lymphocytes in Celiac Disease Engage Enterocyte HLA-E and HLA-B

This study identifies IFNγ-producing intraepithelial CTLs in celiac disease that interact with HLA-E/B on enterocytes, promoting CTL recruitment and epithelial killing.

Targeting redox imbalance through Nrf2 activation in the inflamed coeliac duodenum.

This study uses single-cell transcriptomics to show redox imbalance in coeliac duodenum, with decreased Nrf2 activation in key cell types, and demonstrates that Nrf2 activation reduces inflammation.

A dendritic cell population responsible for transglutaminase 2-mediated gluten antigen presentation in celiac disease

This study identifies intestinal CD103+ dendritic cells as key players in TG2-mediated gluten antigen presentation in celiac disease and shows their role in activating T cells and upregulating TG2 activity.

Immune signaling mediates stromal changes to support epithelial reprogramming in Celiac duodenum

This study identifies immune-stromal-epithelial communication in CeD duodenum using scRNA-seq, revealing fibroblast-mediated epithelial reprogramming through IL-1β and IFN-γ signals.

Investigating intestinal epithelium metabolic dysfunction in Celiac Disease using personalized genome scale models

The paper constructs personalized genome-scale models of sIEC metabolism in CeD to identify metabolic dysfunctions and potential therapeutic drugs.

One year of gluten free diet impacts gut function and microbiome in celiac disease

This study examines the effects of a one-year gluten-free diet on gut function and microbiome in celiac disease patients compared to healthy volunteers.

Saliva direct PCR protocol for HLA-DQB1*02 genotyping

The paper develops a saliva direct PCR protocol for HLA-DQB1*02 genotyping, enabling detection of the allele without DNA purification.

Systematic prioritization of candidate genes in disease loci identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease

The paper identifies TRAFD1 as a master regulator of IFNγ signalling in celiac disease by systematically prioritizing candidate genes in disease loci using multiple computational methods.

Improved HLA-based prediction of coeliac disease identifies two novel HLA risk modifiers, DQ6.2 and DQ7.3

The paper improves HLA-based prediction of coeliac disease by identifying two novel risk modifiers, DQ6.2 and DQ7.3, and develops a new risk score with better predictive performance.

Persistent alterations in plasma lipid profiles prior to introduction of gluten in the diet associate with progression to celiac disease

The paper identifies lipid profile changes in children before gluten introduction that associate with progression to celiac disease.