Long-Term Effects of COVID-19

Understanding cognitive function in post-COVID-19 condition with fatigue: an interdisciplinary multimodal investigation

This study investigates cognitive symptoms in post-COVID-19 condition with fatigue, finding subtle neurobiological changes not captured by standard assessments.

Persistently activated virus-specific CD8 T cells indicate antigen-driven immune aberrations in long COVID

The paper identifies persistently activated virus-specific CD8 T cells in long COVID patients, suggesting chronic antigen stimulation by SARS-CoV-2 or herpesvirus.

Breathlessness catastrophising after COVID-19 involves both interoceptive and visceromotor connectivity

This study identifies two brain connectivity patterns associated with breathlessness catastrophising in post-COVID patients, suggesting both interoceptive and visceromotor pathway alterations.

Identification of Altered Potassium Channels for Drug Repurposing in Long COVID Patients

The paper identifies altered potassium channels in Long COVID patients and suggests potential drug repurposing opportunities targeting these channels.

Multiomic and Spatial Profiling of Colorectal Tissue Reveals Viral Persistence and Immune Dysregulation in Long COVID

This study uses multiomic and spatial profiling of colorectal tissue and blood to show that Long COVID is linked to immune dysregulation and viral persistence, with stronger signals in tissue than blood.

Neuroanatomical subtypes of Long COVID reveal distinct cognitive profiles alongside longitudinal brain changes

The paper identifies two neuroanatomical subtypes of Long COVID with distinct structural brain patterns and cognitive profiles using MRI and cognitive assessments.

Molecular, cellular and network mapping of brain structural deviations in patients with Post-COVID19 syndrome

This study identifies structural brain deviations in post-COVID-19 patients using normative modelling and network analysis, linking them to TMPRSS2 expression and neural circuit disruptions.

SARS-CoV-2 S1 spike protein induces a temporal systemic immune response and promotes long-term anxiety-like behaviors

This study investigates how SARS-CoV-2 S1 protein induces systemic immune responses and long-term anxiety-like behaviors in mice.

Single-cell profiling of innate and adaptive immune dysregulation in Long COVID

This study uses single-cell profiling to analyze immune dysregulation in Long COVID patients, identifying distinct immune signatures associated with symptom severity.

No objective evidence of neuropsychological deficits in people with subjective cognitive changes following COVID-19 infection

This study finds no objective cognitive deficits in individuals with post-COVID-19 subjective cognitive complaints, but links them to higher depression/anxiety and biological markers like APOE-ε4 and sCD14.

Chronic cocaine exposure negatively impacts Long-COVID-like outcomes produced by the SARS-CoV-2 spike protein in the rat

This study shows that chronic cocaine exposure worsens Long-COVID-like outcomes in rats after SARS-CoV-2 spike protein exposure, including reduced weight gain, increased pain sensitivity, and altered behavior.

Longitudinal analysis reveals myeloid cell contributions to neuroPASC pathogenesis

This study uses longitudinal single-cell RNA sequencing to show that myeloid cells contribute to sustained neuroinflammation in neuroPASC, with microglia playing a central role.

Pathogenic IgG from long COVID patients with neurological sequelae triggers sensitive but not cognitive impairments upon transfer into mice

The paper investigates whether IgG from long COVID patients with neurological symptoms can induce pain-related symptoms in mice, finding that they bind to sensory neurons and cause transient mechanical allodynia.

TACO: TabPFN Augmented Causal Outcomes for Early Detection of Long COVID

TACO detects presymptomatic Long COVID by combining causal inference with a foundation model, achieving higher precision with fewer features and no hyperparameter tuning.

Intranasal Anti-CD3 Antibody Treatment Attenuates Post-COVID Neuroinflammation and Enhances Hippocampal Neurogenesis and Cognitive Function in Mice

This study shows nasal anti-CD3 antibody treatment reduces neuroinflammation, enhances neurogenesis, and improves cognitive function in a mouse model of Long COVID.

Persistent SARS-CoV-2 Spike is Associated with Localized Immune Dysregulation in Long COVID Gut Biopsies

This study identifies immune dysregulation linked to persistent SARS-CoV-2 Spike in gut biopsies of Long COVID patients using spatial transcriptomics and immunofluorescence.

Transfer of IgG from Long COVID patients induces symptomology in mice

This study transfers IgG from Long COVID patients to mice, inducing distinct symptoms based on patient subgroups, supporting a causative role for IgGs in Long COVID.

The serum from critical COVID-19 patients induces proteomic changes in olfactory neuroepithelial cells that resemble post-covid neurological complications

This study shows that serum from critical COVID-19 patients alters proteomic profiles in olfactory neuroepithelial cells, linking systemic factors to neurological complications seen in Long COVID.

Microbiota-derived extracellular vesicles link intestinal dysbiosis to neuroimmune activation in long COVID

This study identifies gut microbiota-derived extracellular vesicles as mediators linking intestinal dysbiosis to neuroimmune activation in Long COVID.

Pediatric Long COVID Is Characterized by Myeloid CCR6 Suppression and Immune Dysregulation

This study identifies immune dysregulation and myeloid CCR6 suppression in pediatric long COVID, with CCR6 expression distinguishing long COVID from controls.

Multimodal imaging suggests potential immune-vascular contributions to altered regional brain perfusion and oxygen metabolism in Post-COVID-19 Syndrome

This study uses multimodal MRI to find altered brain perfusion and oxygen metabolism in PCS, linked to cognitive and emotional symptoms.

Diminished EBV-Specific Humoral Immunity is Associated with Neuropsychiatric Long COVID Development up to 12 Months Post-COVID-19 Symptom Onset

This study investigates immune responses to SARS-CoV-2 and EBV in neuropsychiatric long COVID patients and finds reduced EBV neutralization linked to persistent fatigue.

Disruption of the hypothalamic orexin system links SARS-CoV-2 infection to persistent cortical neuronal pathology

This study shows SARS-CoV-2 causes lasting cortical neuronal injury and hypothalamic orexin dysfunction, linking it to Long COVID neurological symptoms.

EEG Signatures of COVID-19 Survival compared to close contacts and the Cuban EEG normative database

The paper compares EEG patterns between COVID-19 survivors, close contacts, and a normative database to identify brain function impairments and abnormal activity patterns.

Post-translational modifications within fibrinaloid microclot complexes distinguish Pre-COVID-19 Postural Orthostatic Tachycardia Syndrome, Long COVID, and Long COVID-POTS and reveal disease-specific molecular pathways

This study identifies distinct post-translational modifications in fibrinaloid microclots across Pre-COVID-19 POTS, Long COVID, and LC-POTS, revealing disease-specific molecular pathways.

Flu Virus Infection in Juvenile Mice Leads to Lifelong Multi-Organ Damage and Parkinsonian Pathological Changes in Aging

This study shows that influenza infection in juvenile mice causes lifelong multi-organ damage and Parkinsonian changes in aging, with persistent inflammation and secreted proteins mediating systemic effects.

Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry

This study identifies a genetic association between thromboembolism risk and long COVID in individuals of European ancestry, suggesting thromboembolism as a potential contributor to long COVID pathogenesis.

Omics-Based Computational Approaches for Biomarker Identification, Prediction, and Treatment of Long COVID

This paper reviews computational methods and datasets for understanding Long COVID's mechanisms and developing diagnostic and therapeutic strategies using multi-omics data.

Integrative Multi-Omics Framework for Causal Gene Discovery in Long COVID

This paper identifies 32 causal genes for Long COVID using a multi-omics framework combining TWMR and CT, revealing novel genetic factors and symptom subtypes.

Mechanisms of sex differences in acute and long COVID sequelae in mice

This study identifies sex differences in long COVID sequelae in mice, showing that X-linked genes like Xist and Tlr7 contribute to persistent inflammation and cognitive impairments in females.