Long-Term Effects of COVID-19

CBM KG: A Comorbidity-Centric Knowledge Graph Uncovering Causal Pathomechanisms Between COVID-19 and Neurodegenerative Diseases

The paper introduces CBM KG, a knowledge graph linking COVID-19 and neurodegenerative diseases through causal mechanisms, integrating 2,800 relationships from 63 studies.

Persistent Immune Dysregulation during Post-Acute Sequelae of COVID-19 is Manifested in Antibodies Targeting Envelope and Nucleocapsid Proteins

This study examines immune dysregulation in Long COVID patients, finding persistent elevated anti-envelope and nucleocapsid antibodies and increased autoantibodies over six months.

Effect of obesity on the acute response to SARS-CoV-2 infection and development of post-acute sequelae of COVID-19 (PASC) in nonhuman primates

This study investigates how obesity affects the long-term effects of SARS-CoV-2 infection in nonhuman primates, finding persistent changes in multiple parameters in most animals.

Hamsters with long Covid exhibits a neurodegenerative signature in the brainstem

This study shows that SARS-CoV-2 infects and persists in hamster brainstem, causing neurodegenerative and immunometabolic changes linked to neuropsychiatric and cognitive symptoms.

Molecular Insights into Long COVID: Plasma Proteomics Reveals Oxidative Stress, Coagulation Cascade Activation, and Glycolytic Imbalance

This study uses plasma proteomics to identify molecular changes in long COVID, revealing oxidative stress, coagulation activation, and glycolytic imbalance.

Oxidative Stress is a shared characteristic of ME/CFS and Long COVID

This study identifies elevated oxidative stress in both ME/CFS and Long COVID patients through blood cell analysis, suggesting shared molecular mechanisms and potential therapeutic targets.

Immunological and clinical markers of post-acute sequelae of COVID-19: Insights from mild and severe cases six months post-infection

This study identifies immunological markers associated with PASC in patients six months post-COVID-19 infection, showing altered T-cell subsets and cytokine profiles linked to disease severity and symptom duration.

COVID-19 induces persistent transcriptional changes in adipose tissue that are not associated with Long COVID

The paper examines transcriptional changes in adipose tissue from subacute COVID-19 and Long COVID patients, finding no persistent viral RNA but significant transcriptional remodeling in subacute cases and no consistent gene expression differences in Long COVID.

Genome-wide Association Study of Long COVID

This study performs a genome-wide association study for Long COVID, identifying a significant association with the FOXP4 locus and highlighting the role of pulmonary dysfunction and COVID-19 severity.

LEF1-AS1 deregulation in the peripheral blood of patients with persistent post-COVID symptoms

This study investigates ncRNA expression in long COVID patients and finds LEF1-AS1 downregulation in PBMCs of symptomatic individuals.

AI-based decoding of long covid cognitive impairments in mice using automated behavioral system and comparative transcriptomic analysis

This study uses an automated behavioral system and transcriptomic analysis to identify cognitive impairments in mice with long COVID, finding similar transcriptomic changes to humans.

Mobius: Mixture-Of-Experts Transformer Model in Epigenetics of ME/CFS and Long COVID

Mobius, a transformer model using DNA methylation data, accurately distinguishes ME/CFS, Long COVID, and healthy controls with high performance.

Reproducibility of Genetic Risk Factors Identified for Long COVID using Combinatorial Analysis Across US and UK Patient Cohorts with Diverse Ancestries

This study reproduces genetic risk factors for long COVID identified in a European ancestry cohort across ancestrally diverse populations, showing significant enrichment of disease signatures and supporting drug repurposing candidates.

Transient, early, female-specific increase in cortical glial fibrillary acidic protein distribution in the Syrian hamster model of mild peripheral COVID-19

The paper quantifies astrogliosis in a Syrian hamster model of mild-moderate COVID-19, finding a transient, female-specific increase in GFAP signal density in the cortex at 3 days post-inoculation.

Neuroinvasive and neurovirulent potential of SARS-CoV-2 in the acute and post-acute phase of intranasally inoculated ferrets

This study investigates SARS-CoV-2 neuroinvasive and neurovirulent potential in ferrets with mild respiratory disease, finding limited neuroinvasion but evidence of neurovirulence through microglial and astrocytic changes.

Crosstalk Among Disrupted Blood-Brain Barrier, Neuroinflammation, and Coagulopathy in AC70 hACE2 Tg Mice with Prolonged Neurological Manifestations Induced by the Omicron BA.1 Variant of SARS-CoV-2

This study investigates prolonged neurological effects in AC70 hACE2 Tg mice infected with Omicron BA.1, showing BBB disruption, neuroinflammation, and coagulopathy contribute to long-COVID-like symptoms.

Neuropsychiatric sequelae in an experimental model of post-COVID syndrome in mice

This study establishes a sex-dependent mouse model of post-COVID syndrome, showing neuropsychiatric and musculoskeletal complications in females that are prevented by ovariectomy.

SARS-CoV-2 Infects Peripheral Sensory Neurons and Promotes Axonal Degeneration via TRPV1 Activation

This study shows SARS-CoV-2 infects sensory neurons via ACE2 and TRPV1, causing axonal damage, and that TRPV1 antagonists can protect neurons.

Unveiling the Immune Landscape of COVID-19 and prolonged Long-COVID through Single-Cell RNA Sequencing

This study uses single-cell RNA sequencing to analyze immune cell states in COVID-19 and Long-COVID patients, revealing persistent immune dysregulation 1.5-2 years post-infection.

Integrative Genome-Wide Association Studies of COVID-19 Susceptibility and Hospitalization Reveal Risk Loci for Long COVID

This study identifies 62 candidate risk loci for long COVID using GWAS data and finds most show weaker associations with long COVID compared to acute-phase COVID-19.

Identification of a multi-omics factor predictive of long COVID in the IMPACC study

The paper identifies a multi-omics recovery factor predictive of long COVID using data from the IMPACC study, showing it can predict LC risk early after infection.

The K18-hACE2 mouse model of SARS-CoV-2 infection to illustrate the role and response of the vasculature in neurotropic viral infection

This study uses a K18-hACE2 mouse model to show SARS-CoV-2 infects neurons in the brain without damaging blood vessels, leading to limited neuroinflammation.

Gut Microbiome Signatures During Acute Infection Predict Long COVID

The paper identifies distinct gut microbiome signatures during acute SARS-CoV-2 infection that predict long COVID, showing microbiome profiles better predict risk than clinical variables.

Systemic exposure to COVID-19 virus-like particles modulates firing patterns of cortical neurons in the living mouse brain

This study shows that systemic exposure to SARS-CoV-2 virus-like particles disrupts cortical neuronal activity in mice, with persistent effects and heightened vulnerability in htau mice.

Sex differences and immune correlates of Long COVID development, persistence, and resolution

This study identifies sex-specific immune correlates of Long COVID development, persistence, and resolution using multi-omic analyses of blood samples from patients with and without Long COVID.

A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection

This study uses a mouse-adapted SARS-CoV-2 strain to model long-term post-acute sequelae of COVID-19, finding persistent neurological and multi-organ impairments in mice after mild infection.

Fatigue >12 weeks after coronavirus disease (COVID) is associated with reduced reward sensitivity during effort-based decision making

The paper investigates whether fatigue and depressive mood after COVID-19 are associated with altered decision-making, finding that post-COVID fatigue reduces reward sensitivity.

Multi-ancestry GWAS of Long COVID identifiesimmune-related loci and etiological links to chronic fatigue syndrome, fibromyalgia and depression

This study performs a multi-ancestry GWAS of Long COVID, identifying immune-related loci and genetic links to chronic fatigue syndrome, fibromyalgia, and depression.

Characterizing neuroinvasion and neuropathology of SARS-CoV-2 by using AC70 human ACE2 transgenic mice

This study investigates SARS-CoV-2 neuroinvasion via the trigeminal nerve in AC70 human ACE2 transgenic mice, finding it as an efficient route with altered neuronal function and gene expression but limited tissue pathology.

Persistent Neurological Deficits in Mouse PASC Reveal Antiviral Drug Limitations

This study shows that antiviral drugs fail to prevent neurological deficits in SARS-CoV-2-infected mice, which resemble neurodegenerative diseases due to chronic inflammation.