Cerebrospinal fluid and hydrocephalus

Varying perivascular astroglial endfoot dimensions along the vascular tree maintain perivascular-interstitial flux through the cortical mantle

The paper characterizes astrocyte endfoot dimensions along the vascular tree in mice and shows that varying endfoot sizes maintain perivascular-interstitial fluid flux despite pressure changes.

Improvement of glymphatic-lymphatic drainage of beta-amyloid by focused ultrasound in Alzheimer's disease model

This study shows that focused ultrasound with microbubbles improves beta-amyloid drainage in Alzheimer's model mice by enhancing brain-to-cerebrospinal fluid clearance.

Functional hyperemia drives fluid exchange in the paravascular space

This study shows that functional hyperemia drives fluid exchange in the paravascular space by interacting with brain tissue deformability.

Convective forces increase rostral delivery of intrathecal antisense oligonucleotides in the cynomolgus monkey nervous system

This study shows that increasing convective forces after intrathecal injection improves rostral distribution of therapeutic ASOs in the CNS of cynomolgus monkeys.

Realistic boundary conditions for perivascular pumping in the mouse brain reconcile theory, simulation, and experiment

The paper reconciles fluid dynamics theory, simulation, and in vivo measurements of CSF flow in mouse brains by applying realistic boundary conditions.

Arterial pulsations drive oscillatory flow of CSF but not directional pumping

This study uses fluid dynamic simulations to show that arterial pulsations cause oscillatory CSF motion, not directional pumping, and that directional flow results from pressure differences.

The coupling of global brain activity and cerebrospinal fluid inflow is correlated with Alzheimer's disease related pathology

The paper shows that coupling between global brain activity and CSF inflow correlates with Alzheimer's disease pathology using ADNI data.

Glutamate and γ-aminobutyric acid differentially modulate glymphatic clearance of amyloid β through pulsation- and aquaporin-4 dependent mechanisms

This study shows that glutamate and GABA modulate glymphatic clearance of amyloid β through distinct mechanisms involving pulsation and AQP4, with potential therapeutic implications for Alzheimer's disease.

Pial surface CSF-contacting texture, subpial and funicular plexus in the thoracic spinal cord in monkey: NADPH diaphorase histological configuration

The paper identifies a specialized neuro-texture in the caudal thoracic spinal cord of monkeys, consisting of NADPH-d positive neurons and plexus structures that may function as CSF sensors.

Uncertainty quantification of parenchymal tracer distribution using random diffusion and convective velocity fields

The paper quantifies uncertainty in tracer distribution in the brain by simulating diffusion and convection models and comparing results to experimental MRI data.

Hydraulic resistance of perivascular spaces in the brain

The paper shows that the observed shapes of perivascular spaces (PVSs) in the brain have lower hydraulic resistance than concentric, circular annuli, allowing faster cerebrospinal fluid flow.

Anatomical basis and physiological role of cerebrospinal fluid transport through the murine cribriform plate

This study investigates the anatomical and physiological role of cerebrospinal fluid transport through the murine cribriform plate and finds that olfactory sensory nerves are critical for CSF outflow.

Numerical simulations of different models describing cerebrospinal fluid dynamics

This paper presents numerical simulations of cerebrospinal fluid dynamics models to confirm and extend theoretical results from a mathematical perspective.

Dynamic 11C-PiB PET shows cerebrospinal fluid flow alterations in Alzheimer’s disease and multiple sclerosis

This study uses dynamic 11C-PiB PET to show reduced cerebrospinal fluid clearance in Alzheimer’s disease and multiple sclerosis compared to healthy controls.

A comparison of two mathematical models of the cerebrospinal fluid dynamics

The paper compares two mathematical models of cerebrospinal fluid dynamics using numerical simulations and validates them against real data from literature.

Aquaporin-4 dependent glymphatic solute transport in rodent brain

This study confirms that AQP4 is essential for glymphatic fluid and solute transport in the rodent brain, as Aqp4 disruption reduces CSF influx and amyloid-beta efflux.

Murine MPDZ-Linked Hydrocephalus is Caused by Hyperpermeability of the Choroid Plexus

This study identifies MPDZ as a gene linked to hydrocephalus in mice, showing that its loss-of-function causes choroid plexus hyperpermeability and increased cerebrospinal fluid protein concentration.

Validation of Davson’s equation in patients suffering from idiopathic Normal Pressure Hydrocephalus

The paper investigates the applicability of Davson’s equation in idiopathic normal pressure hydrocephalus patients, finding a weak but significant correlation between intracranial pressure and outflow resistance.

Cerebral Autoregulation, CSF outflow resistance and outcome following CSF diversion in Normal Pressure Hydrocephalus.

This study examines the relationship between cerebral autoregulation, CSF outflow resistance, and surgical outcomes in normal pressure hydrocephalus patients.