Cerebrospinal fluid and hydrocephalus

CSF circulation and dispersion yield rapid clearancefrom intracranial compartments

The paper models CSF circulation to show that convection in the subarachnoid space rapidly clears tracers from intracranial compartments, reducing clearance time from years to days compared to diffusion.

Cerebrospinal fluid formation is controlled by membrane transporters to modulate intracranial pressure

This study identifies membrane transporters involved in cerebrospinal fluid (CSF) secretion and shows their role in modulating intracranial pressure.

Dysfunctional glymphatic system with disrupted aquaporin-4 expression pattern on astrocytes causes bacterial product accumulation in the CSF during pneumococcal meningitis

This study shows pneumococcal meningitis impairs the glymphatic system, leading to bacterial accumulation in CSF and neuronal damage due to AQP4 misplacement.

Decline of intrinsic cerebrospinal fluid outflow in healthy humans with age detected by non-contrast spin-labeling MRI

This paper introduces a non-contrast spin-labeling MRI technique to quantify CSF outflow in humans and finds that CSF flow metrics decline with age.

Sleep cycle-dependent vascular dynamics enhance perivascular cerebrospinal fluid flow and solute transport

The paper shows sleep cycle-dependent changes in perivascular spaces enhance cerebrospinal fluid flow and solute transport in sleeping mice.

Immediate Impact of Yogic Breathing on Pulsatile Cerebrospinal Fluid Dynamics

This study examines the immediate effects of yogic breathing on pulsatile cerebrospinal fluid (CSF) dynamics using MRI, finding increased cranial CSF velocities during certain breathing patterns.

3D-imaging reveals conserved cerebrospinal fluid drainage via meningeal lymphatic vasculature in mice and humans

The paper establishes the 3D anatomy of meningeal lymphatic vasculature and CSF drainage in mice and humans using imaging techniques, showing conserved lymphatic structures.

Transcriptional profiling of transport mechanisms and regulatory pathways in rat choroid plexus

The paper profiles the transcriptome of rat choroid plexus to identify transport mechanisms and regulatory pathways involved in cerebrospinal fluid secretion.

Characterization of non-human primate dura in health and neurodegeneration

This study characterizes non-human primate dura in health and neurodegeneration, revealing a complex lymphatic system and disease-specific biomarker associations.

Arterial vasodilation drives convective fluid flow in the brain: a poroelastic model

This study uses a poroelastic model to show that arteriolar dilation drives convective fluid flow in the brain, enhancing waste clearance during sleep and sensory activity.

A network model of glymphatic flow under different experimentally-motivated parametric scenarios

The paper models glymphatic flow as a network of hydraulic resistances under different parametric scenarios to identify key parameters influencing CSF dynamics.

A congenital hydrocephalus causing mutation in Trim71 results in stem cell differentiation defects through inhibiting Lsd1 mRNA translation

This study identifies a mutation in Trim71 that causes congenital hydrocephalus by impairing stem cell differentiation through repression of Lsd1 mRNA translation.

Dynamics of brain-fluid circulation are altered in the mature-onset Tet-off APP mouse model of amyloidosis

This study shows altered brain fluid circulation dynamics in a mature-onset AD mouse model, linked to amyloid plaque burden and neuroinflammation.

Impaired peri-olfactory Cerebrospinal Fluid clearance mediated cognitive decline after dyssomnia

This study uses dynamic MRI with contrast agent to assess CSF clearance pathways in humans, finding age-related decline and a link between peri-olfactory pathway function and sleep/cognitive health.

Lysophosphatidic acid, a CSF marker in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1

This study identifies lysophosphatidic acid (LPA) as a biomarker for posthemorrhagic hydrocephalus and shows it drives CSF accumulation through TRPV4-induced hyperactivation of NKCC1.

Coupling between cerebrovascular oscillations and CSF flow fluctuation during wakefulness: An fMRI study

This study uses fMRI to investigate the coupling between cerebrovascular oscillations and CSF flow during wakefulness, finding bidirectional CSF movement and low-frequency facilitation by hemodynamics.

Pulsation changes link to impaired glymphatic function in a mouse model of vascular cognitive impairment

This study shows that bilateral common carotid stenosis impairs glymphatic function and vascular pulsation in mice, contributing to cognitive decline in vascular cognitive impairment.

Acetazolamide modulates intracranial pressure directly by its action on the cerebrospinal fluid secretion apparatus

This study shows acetazolamide reduces intracranial pressure directly by acting on the choroid plexus in rats, without relying on systemic effects.

Autonomic arousals contribute to brain fluid pulsations during sleep

The paper investigates how autonomic regulation of cerebral vascular tone generates CSF pulsations during sleep and may aid in brain waste clearance.

Prostaglandin analog effects on cerebrospinal fluid reabsorption via nasal mucosa

This study investigates the effect of nasal inhalation of prostaglandin F2alpha analogs on cerebrospinal fluid (CSF) outflow via nasal lymphatics in mice, finding increased tracer recovery with latanoprost.

Global cerebrospinal fluid circulation mapping using gold nanoparticle enhanced X-ray microtomography reveals region-specific brain and spinal cord CSF pathways

This study maps CSF pathways in the CNS using gold nanoparticle enhanced X-ray microtomography and identifies region-specific circulation patterns affecting stem cell and neuronal populations.

High permeability of the CSF flow in the juvenile mouse brain by brain-wide DCE-MRI

This study uses MRI to track CSF flow in juvenile mouse brains, finding increased permeability in specific regions until postnatal week 1.

Meningeal lymphatic endothelial cells fulfill scavenger endothelial cell function and employ Mrc1a for cargo uptake

The paper compares brain lymphatic endothelial cells (BLECs) to scavenging endothelial cells (SECs) in the zebrafish and identifies Mrc1a as a key receptor for cargo uptake in BLECs.

OTX2 homeoprotein functions in adult choroid plexus

This study identifies OTX2's roles in adult choroid plexus function through knockdown models and proteomic analysis, revealing its impact on secretion, immune responses, and RNA processing.

Decoupling of global brain activity and cerebrospinal fluid flow in Parkinson's cognitive decline

This study finds that reduced coupling between global brain activity and cerebrospinal fluid flow is associated with cognitive impairment in Parkinson's patients.

Bulk flow of cerebrospinal fluid observed in periarterial spaces is not an artifact of injection

The paper demonstrates that bulk CSF flow in periarterial spaces is not an artifact of injection, using a dual-syringe system that prevents volume changes and pressure increases.

Glymphatic function in the gyrencephalic brain

The paper investigates glymphatic function in a large mammal with a highly gyrified brain, showing CSF penetration and enhanced solute transport compared to mice.

Non-canonical, potassium-driven cerebrospinal fluid clearance

The paper identifies potassium-driven cerebrospinal fluid (CSF) clearance through the choroid plexus during a critical neurodevelopmental phase in mice, showing its role in preventing hydrocephalus.

Photostimulation of lymphatic clearance of red blood cells from the mouse brain after intraventricular hemorrhage

This study shows that photostimulation of meningeal lymphatic vessels in mice with intraventricular hemorrhage reduces mortality and improves recovery by enhancing red blood cell clearance.

Body mass index, time of day, and genetics affect perivascular spaces in the white matter

The paper analyzes cerebral perivascular spaces (PVS) in healthy individuals to establish normal ranges and identifies factors like BMI, time of day, and genetics that influence PVS volume and distribution.