Biochemical Analysis and Sensing Techniques

T2R14 mediated antimicrobial responses through interactions with CFTR

The paper investigates the interaction between T2R14 and CFTR, showing agonist-dependent physical coupling and Gq signaling in response to microbial signals.

Taste receptors' profiling in glioblastoma

This study examines the expression and function of taste receptors in glioblastoma, finding that multiple TAS2Rs and TAS1R subunits are active in tumor cells and may influence cancer microenvironment interactions.

Tyrosine kinase inhibitors affect sweet taste and dysregulate fate selection of specific taste cell subtypes via KIT inhibition.

This study shows that tyrosine kinase inhibitors cause taste dysfunction by altering the fate of taste cell subtypes through KIT inhibition.

Elucidating Odorant Masking Effects in Food Matrices Through Olfactory Receptor-Based Profiling

This study identifies odorant receptors for 2,3,5-trimethylpyrazine and L-menthol and shows they inhibit each other's signaling, revealing molecular mechanisms of odor masking.

The Molecular Signature of Umami Palatability in Dogs Based on Amino Acid Interactions with Canine Taste Receptors.

This study identifies amino acids that optimally stimulate umami taste in dogs using receptor-ligand docking, revealing key amino acids and their interactions with taste receptors.

Glioblastoma cells taste temozolomide via TAS2R43

This study shows that glioblastoma cells use TAS2R43 to detect temozolomide, affecting drug efficacy by modulating MDRs.

Intracellular and Dual-Site Inhibition of a bitter taste GPCR

The paper investigates the inhibitory mechanisms of TAS2R14 antagonists by analyzing mutations and computational models, revealing distinct binding sites and potencies.

Neural coding in gustatory cortex reflects consumption decisions: Evidence from conditioned taste aversion

The paper shows that gustatory cortex neurons in mice represent taste stimuli based on their palatability, with neural patterns reflecting consumption decisions after conditioned taste aversion.

Expectation modulates the hedonic experiences of and midbrain responses to sweet flavour

This study investigates how expectation influences hedonic experiences and midbrain responses to sweet flavors, showing that expectations modulate neural responses and perceived pleasantness of sugar and non-nutritive sweeteners.

Sensory and palatability coding of taste stimuli in cortex involves dynamic and asymmetric cortico-amygdalar interactions

This paper investigates cortico-amygdalar interactions during taste processing in rats, finding asymmetric reciprocal influences and showing that amygdala-cortical loops drive taste encoding and decision-making.

Expression of Calca gene-derived peptides in the murine taste system

The paper investigates the expression of Calca-derived peptides in the murine taste system and identifies distinct expression patterns of preprocalcitonin and CGRP in taste cells and their regulatory receptors.

Estrogen Dependent Variation in the Contributions of TRPM4 and TRPM5 to Fat Taste

The paper investigates how estrogen affects fat taste signaling by examining the roles of TRPM4 and TRPM5 in Type II taste cells across different estrous phases in mice.

T2R5 agonist phendione decreases cell viability and induces apoptosis in head and neck squamous cell carcinoma

Phendione, a T2R5 agonist, reduces cell viability and induces apoptosis in HNSCC cells and tumor samples, with T2R5 expression linked to better survival in HNSCC.

Quercetin as a Bitter Taste Receptor Agonist with Anticancer Effects in Head and Neck Cancer Cells

This study shows quercetin activates T2R14 in HNSCC cells, causing calcium responses, reduced viability, and mitochondrial depolarization.

Parabrachial Calca neurons influence aversive and appetitive taste function

This study investigates how PB-Calca neurons influence aversive and appetitive taste behaviors in mice, finding sex-dependent effects on sucrose preference and quinine avoidance.

Artificial sweeteners differentially activate sweet and bitter gustatory neurons in Drosophila

This study shows artificial sweeteners activate both sweet and bitter taste neurons in Drosophila, with varying behavioral effects depending on concentration and compound type.

Gustatory-neuron-supplied R-spondin-2 is required for taste bud replenishment

This study shows that Rspo2 from gustatory neurons is essential for taste bud maintenance through genetic experiments in mice.

GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine

This study identifies GPRC6A as a novel kokumi receptor that mediates enhanced taste preferences induced by ornithine in rats.

Death in the taste bud: engulfment of dying taste receptor cells by glial-like Type I cells

The paper identifies dying taste receptor cells in murine taste buds and shows that glial-like Type I cells engulf them, suggesting a phagocytic role for Type I cells.

Neural Processing of Taste-related Signals in the Mediodorsal Thalamus of Mice.

This study shows that MD neurons in mice encode taste identity, concentration, and predictive cues related to rewarding or aversive outcomes.

Bitter Taste Receptor Agonists Induce Apoptosis in Papillary Thyroid Cancer

This study shows bitter taste receptor agonists induce apoptosis in papillary thyroid cancer cells and higher TAS2R14 expression correlates with better patient survival.

Cortical Coding of Gustatory and Thermal Signals in Active Licking Mice

This study examines how gustatory cortex (GC) neurons encode thermal and chemosensory signals during licking in mice, finding that GC neurons use rate and phase information to distinguish temperature differences.

Structural comparisons of human and mouse fungiform taste buds

This study compares the structural features of human and mouse fungiform taste buds, finding differences in size, innervation density, and synaptic contact size.

Worldwide study of the taste of bitter medicines and their modifiers

This study examines bitterness perception of medicines and modifiers across diverse ancestries, finding ancestry-related differences in bitterness ratings and genetic associations with taste sensitivity.

Innate liking and disgust reactions elicited by intraoral capsaicin in male mice

This study shows that capsaicin induces liking and disgust reactions in male mice through orofacial and bodily responses, similar to taste reactivity.

Adiponectin signaling modulates fat taste responsiveness in mice

This study identifies AdipoR1 as the mediator of adiponectin/AdipoRon's effect on fatty acid-induced calcium responses in mouse taste cells, but finds no behavioral change in fat taste.

The main duct of von Ebner's glands is a source of Sox10+ taste bud progenitors and susceptible to pathogen infections

Electrophysiological responses to appetitive and consummatory behavior in the rostral nucleus tractus solitarius in awake, unrestrained rats

This study records single-cell electrophysiological responses in the rostral nucleus tractus solitarius (rNTS) of awake rats during food exploration and licking, showing distinct activity patterns during appetitive and consummatory phases of eating.

Learning enhances representations of taste-guided decisions in the mouse gustatory insular cortex

This study shows that learning improves decision-related neural activity in the mouse gustatory insular cortex during taste discrimination tasks.

Glucose appetition in C57BL/6J mice: Influence of nonnutritive sweetener experience, food deprivation state and sex differences

The paper investigates how nonnutritive sweetener experience, food deprivation, and sex affect glucose appetition in mice, finding that food restriction enhances glucose licking but is not needed for flavor preference.