Nuclear Structure and Function

The paper examines how nuclear lamina association and genome compartmentalization influence gene regulation across different cell types and treatments.

This study shows that lysolipid treatment alters NE lipid composition, reducing Sir4 telomere association and triggering lipid-specific transcriptional changes in yeast.

This study identifies lamin A/C phosphorylation at Ser22 as a conserved heat shock response that regulates nuclear structure and cell survival during stress.

The paper maps lamin-associated chromatin across twelve human cell types, identifying two subtypes with distinct features and developmental dynamics.

This study identifies transcriptional deficits in HGPS fibroblasts related to mesenchymal differentiation and endochondral ossification, with age-dependent gene expression changes.

The paper measures nuclear transport rates in single yeast cells using FRAP and identifies variability in nuclear pore complexes and other factors as sources of cell-to-cell differences.

The paper shows that nucleoporins, specifically Elys, are required for ORC2 loading onto chromatin and proper replication initiation in Drosophila.

This study identifies DNAJB6 as a molecular chaperone that prevents FG-Nup aggregation during interphase nuclear pore complex biogenesis.

The paper identifies that differential nuclear import timing controls gene expression onset in early embryonic development by regulating protein access to the genome.

This study determines the structure of Importin-4 bound to the H3-H4·ASF1 complex, revealing how Importin-4 recognizes and transports the histone chaperone complex into the nucleus.

The paper shows nucleolar targeting in Trypanosoma brucei is mediated by positive charge, contributing to sorting of mitochondrial and cytoplasmic ribosome proteins.

The paper investigates the role of CTCF and cohesin in LAD positioning, finding they reinforce borders but do not position LADs, and mediate fine-tuning of nuclear lamina interactions.

The paper uses AI to create a dynamic model of the human nuclear pore complex, showing how the protein scaffold interacts with the nuclear envelope.

This study shows that impaired Lef1 activation in HGPS iPSCs accelerates keratinocyte differentiation, and base editing partially rescues this phenotype.

The paper shows that in Saccharomyces cerevisiae, RNAP II produces capped 18S and 25S rRNAs resistant to 5-monophosphate dependent exonuclease, indicating a new role for RNAP II in ribosome biogenesis.

This study shows that reducing Nup98-96 function in Drosophila leads to defects in protein synthesis and JNK signaling, promoting tumorigenesis when apoptosis is inhibited.

The paper shows that the Nup84 complex restricts Ty retrotransposon transcription in yeast by tethering Ulp1 to NPCs, preventing retrotransposition.

This study identifies phosphorylation of Mps3's luminal region as critical for its nuclear envelope localization during meiosis, mediated by CDK and DDK.

The paper identifies a novel DNA-binding domain in importin α2 that enables chromatin association, revealing its dual role in nuclear transport and gene regulation.

The paper introduces a DNA-origami NanoTrap to study diffusion barriers formed by FG-nups and finds that motif type, density, and arrangement are critical for barrier effectiveness.

This study shows that a mutation in the maize aladin1 gene disrupts asymmetric cell division and affects plant growth and structure.

The paper identifies proteins associated with the nuclear lamina and lamin associated domains using BioID and m6A-tracer systems, revealing key regulators of LAD function.

This study identifies Importin-9's role in Drosophila germ cell nuclear processes, showing its necessity for chromosome segregation, histone-to-protamine transition, and proteasome function during gametogenesis.

This study identifies 362 conserved nuclear matrix proteins in Drosophila species, finding 132 originated from prokaryotes and 68 are conserved across all eukaryotes.

The paper identifies early chromatin structural changes in HGPS using a new method, showing Polycomb target gene deregulation linked to lamin-associated domain disruption.

The paper develops pA-DamID to study LAD-NL contacts during interphase, finding rapid early G1 establishment and differential dynamics between distal and centromere-proximal LADs.

The paper uses a cellular assay to identify new NES motifs in cancer-related proteins and discovers NES-harbouring micropeptides.

The paper investigates how gene activation affects nuclear lamina interactions and shows that transcription can locally rewire these interactions without broadly altering chromosomal regions.

The paper shows that the L1 stalk is essential for efficient export of pre-60S ribosomal subunits in yeast, despite previous findings suggesting otherwise.