Nuclear Structure and Function

The paper identifies a conserved meiotic mechanism called virtual nuclear envelope breakdown (vNEBD) in yeast, regulated by Ime2 kinase and Gip1 phosphatase.

This study shows that LMNA deficiency in SCLC increases R-loop accumulation, leading to genomic instability and poor patient survival.

The paper demonstrates that nuclear envelope budding facilitates the export of large muscle-specific transcripts during myotube formation, involving UIF and ESCRT-III machinery.

The paper shows telomeres initiate nuclear envelope reassembly during mitosis, ensuring proper chromosome encapsulation and preventing micronuclei formation.

This study identifies SRSF1 as a pH-regulating factor that maintains nucleolar integrity by alkalizing the nucleolar microenvironment through its RS domain.

This study investigates how lamins and nesprins influence gene expression through chromatin conformation changes using RNA-seq and live imaging techniques.

The paper identifies molecular determinants enabling HIV capsid passage through NPCs by analyzing surface amino acid composition and FG repeat interactions.

This study investigates how O-GlcNAc modifications influence lamin A tail processing and identifies a potential link between glucose metabolism and lamina biogenesis.

This study shows that self-assembly is essential for the nuclear membrane recruitment of Drp6, a nuclear dynamin-related protein, independent of its membrane binding ability.

This study investigates the roles of Ki-67, GNL2, and MDN1 in ribosome biogenesis and transcriptome regulation in HEK293T neuronal lineage cells, revealing their impact on nucleolar function, pre-60S particle export, and neuronal development.

This study shows that an inhomogeneous nuclear pore complex with varying FG-Nup lengths enhances selectivity for karyopherin-bound cargo transport.

This study uses GSEA to examine how LBR knockdown affects differentiation and phenotypic differences in HL-60 cell lines, finding changes in heterochromatin, ribosome proteins, and nucleolar structure.

This study identifies PMLII as forming biomolecular condensates at sites of nuclear envelope disruption, suggesting a role in stabilizing the site for repair.

This study shows elevated SUN1 disrupts cell polarity by coupling microtubules to the nuclear lamina, affecting mechanical force transmission during aging.

This study identifies 174 arsenic-binding proteins in yeast, showing that arsenic disrupts nucleocytoplasmic transport by causing mislocalization and aggregation of nuclear transport factors.

The paper identifies three distinct LAD classes based on histone modification patterns in mouse MEF cells, revealing heterochromatin-specific regulatory roles.

The paper shows that H1.8 and NPM1 partition into the nucleus via surface condensation, independent of nuclear import and DNA-to-cytoplasm ratio.

This study investigates the structural and functional changes in human sperm nuclear pore complexes (NPCs) during spermatogenesis, revealing a reduced central channel and altered transport dynamics.

The paper shows that rRNA transcription continues in differentiating lens fiber cells until nuclear degradation, supporting translational mechanisms for crystallin protein production.

This study identifies Nup153 as a docking point for splicing machinery at the nuclear pore, showing its role in mRNA processing and gene splicing.

This study shows that nuclear type I myosins are essential for yeast cell viability and genome organization, with their depletion causing 3D genome disorganization and nuclear structural defects.

The paper introduces ExIGS, a method linking nuclear abnormalities to chromatin repression hotspots in progeria fibroblasts.

The paper determines the Cryo-EM structure of PPARγ in complex with Transportin-1, revealing a non-canonical NLS recognition mechanism.

The paper identifies FG-nucleoporins (FG-NUPs) at plasmodesmata (PD) using bioinformatics, proteomics, and imaging, suggesting a potential role in intercellular transport.

The paper shows that cancer cells use a NE assembly pattern linked to fragility, differing from normal cells.

This study shows that nuclear invaginations regulate ribosome biogenesis by contacting nucleoli, with high curvature increasing ribosome production and low curvature reducing it.

The paper uses site-specific deuteration and SANS to study the dynamic structure of FG Nups interacting with NTF2, revealing their fully disordered nature and lack of significant inter-aromatic contacts.

This study investigates the effects of Lamin B Receptor knockdown on the transcriptome and morphology of HL-60/S4 cells, identifying changes in Golgi and ribosome-related genes and nucleolar structure.

This study identifies NE rupture in LMNA-DCM cardiomyocytes as a driver of transcriptomic changes and immune activation, which can be reversed by LINC complex disruption.

The paper shows that anchoring H3K9-methylated heterochromatin to the nuclear periphery is necessary for P-cell nuclear migration through constrictions in C. elegans, independent of the LINC complex.