Viral Infections and Vectors

Structural Insights and Inhibitor Discovery for Kyasanur Forest Disease Virus NS5 Methyltransferase

The paper reports the crystal structures of KFDV NS5 methyltransferase and evaluates HC and CAPE as inhibitors against the enzyme.

Persistent circulation of Rift Valley fever virus lineage C in Rwanda, 2022-2025

This study shows Rift Valley fever virus lineage C circulates persistently in Rwanda through local transmission, not repeated introductions, based on whole-genome sequencing of livestock samples from 2022-2025.

A historical cross-border Andes virus lineage reveals the origin of a cruise ship hantavirus pulmonary syndrome outbreak

The paper traces the origin of a cruise ship hantavirus pulmonary syndrome outbreak to a specific geographic corridor in the Andes using genomic analysis of Andes virus sequences.

Co-circulating TBEV lineages and evidence for vertical transmission in wild bank voles from Poland

The paper investigates TBEV circulation and vertical transmission in bank voles in Poland, finding co-circulating viral lineages and evidence of vertical transmission.

Pericyte dysfunction alone may be insufficient to drive tick-borne orthoflavivirus NS1-mediated microvascular permeability

This study investigates whether NS1 from AHFV and KFDV disrupts microvascular barrier integrity in pericyte-endothelial cell cocultures and finds that pericyte dysfunction alone is insufficient to drive NS1-mediated microvascular permeability.

Mammarenavirus-Induced Remodeling of the Cellular Lipid Landscape Reveals Sphingolipid Metabolism as a Novel Target for Antiviral Intervention

This study identifies sphingolipid metabolism as a target for antiviral strategies against mammarenaviruses by showing that inhibiting nSMase2 reduces viral production.

Hantavirus stability and inactivation

This study investigates the stability of hantaviruses under various environmental stresses and evaluates inactivation methods, finding that they are stable under some conditions but can be effectively inactivated by common methods.

Development and qualification of an enzyme-linked immunosorbent assay to detect human serum immunoglobulin G reactive to multiple lineages of Lassa virus nucleoprotein

This paper develops and validates an ELISA to quantify anti-LASV-NP IgG in human serum, demonstrating sensitivity, precision, and specificity for LASV epidemiology and vaccine development.

Interaction of Bunyamwera Virus Non-Structural Protein NSm with Cellular BNIP1 is Required for Efficient Viral Gene Expression and Replication

This study identifies BNIP1 as a host factor required for Bunyamwera virus replication, showing its interaction with NSm and dependence on COPI vesicle trafficking.

Oropouche virus causes acute hepatitis in mice controlled by Type I interferons

This paper establishes two mouse models of Oropouche virus-induced hepatitis, showing that Type I interferons control disease severity and that contemporary isolates are less pathogenic than historical strains.

Crop-specific agricultural land use and Rift Valley fever outbreaks in Uganda: a longitudinal compositional analysis

This study links banana cultivation to increased Rift Valley fever outbreak risk in Uganda using satellite data and statistical modeling.

Pathogenesis and host response to a novel Tacaribe virus isolate in experimentally-infected Jamaican fruit bats

This paper isolates and characterizes a novel Tacaribe virus (TCRV) strain from Jamaican fruit bats, showing it causes nonfatal infection with mild liver disease and limited immune response, offering a better model for studying arenavirus biology than previously used strains.

First detection and characterization of Alongshan virus in Ixodes ricinus ticks from Italy, 2021-2022

The paper detects and characterizes Alongshan virus in Ixodes ricinus ticks from Italy, finding 13.2% positivity and phylogenetic similarity to European strains.

Computationally hybridized pathogenic mammarenavirus receptor binding domains reveal cryptic variants that elicit cross-neutralizing immune responses

The paper investigates hybridized JUNV-MACV GP1 variants, showing they enable virus entry and are recognized by cross-neutralizing antibodies, suggesting potential for antiviral therapy design.

Functional divergence of the NSs protein defines interferon antagonism and viral fitness across Bhanja virus lineages.

Structural and functional characterisation of the Crimean-Congo Haemorrhagic Fever Virus RNA Dependent RNA Polymerase

This study characterizes the structure and function of CCHFV RNA-dependent RNA polymerase, revealing its unique features and antiviral susceptibility.

Detection and genomic characterisation of a novel hantavirus in Australian dolphins

The paper detects a novel hantavirus in Australian dolphins and places it within the Mobatvirus genus, indicating hantaviruses can infect non-terrestrial mammals.

Maternal antibody-mediated elimination of a Puumala hantavirus outbreak in a bank vole colony

The paper describes the eradication of a Puumala hantavirus outbreak in a bank vole colony using maternal antibodies to protect offspring and eliminate the virus from subsequent generations.

Crimean-Congo Haemorrhagic Fever Virus Circulates within Broad Ecological Networks of Ticks and Vertebrates

This paper models the distribution of Crimean-Congo haemorrhagic fever virus by integrating climatic, tick, and vertebrate data, showing that ecological interactions, not climate alone, determine its range.

Orthohantavirus-related Proteases as Therapeutic Targets: Opportunities for Antiviral Drug Development

The paper identifies potential protease inhibitors targeting host ER proteases for antiviral drug development against orthohantaviruses, with Compound E showing the highest binding confidence.

Contact networks of small mammals highlight potential transmission foci of Mammarenavirus lassaense

The paper examines small mammal contact networks in Sierra Leone to identify potential transmission foci of Mammarenavirus lassaense, finding that land use affects rodent-rodent interactions and seroprevalence patterns.

CD164 is an endolysosomal host factor for entry of Clade A New World Arenaviruses

The paper identifies CD164 as an endolysosomal receptor for clade A New World arenaviruses, expanding the receptor switching paradigm observed in Old World arenaviruses.

Sensitivity analysis of factors influencing the ecology of mosquitoes involved in the transmission of Rift Valley fever virus

This paper uses a mathematical model to analyze how ecological factors influence mosquito populations involved in Rift Valley fever transmission, identifying key parameters affecting mosquito abundance and disease risk.

Development and validation of two economical and flexible immunoassays for detecting antibodies against LCMV in mouse serum

This paper develops and validates two cost-effective immunoassays for detecting LCMV antibodies in mouse serum, showing high sensitivity and specificity across multiple timepoints.

Molecular Identification and Characterization of mobatvirus (Hantaviridae) in Lao PDR

The paper identifies and characterizes new mobatvirus variants in Lao PDR bats and wild animals, revealing genetic diversity and potential zoonotic risk.

Human monoclonal antibodies that target the SFTSV glycoprotein Gn head from four neutralizing epitope groups

The paper isolates human monoclonal antibodies against SFTSV Gn, identifies four neutralizing epitope groups, and validates their neutralization through structural analysis.

Molecular dialogue between Orthonairovirus and tick: RNA-protein interactome of Hazara virus, a BSL2 model of Crimean-Congo Hemorrhagic Fever virus, in Hyalomma cells

This study identifies RNA-protein interactions between Hazara virus and Hyalomma tick proteins using ChIRP-MS, revealing mitochondrial RNA-binding proteins involved in metabolic pathways.

Drug repurposing high-throughput screen identifies candidate antiviral compounds against Puumala Orthohantavirus

The paper identifies 70 antiviral compounds against Puumala Orthohantavirus through a drug repurposing screen in human cell lines.

A mouse-adapted Yezo virus model for antiviral testing in immunocompetent mice

The paper develops a mouse-adapted Yezo virus model that causes lethal infection in immunocompetent mice, identifies key mutations enhancing virulence, and evaluates antiviral efficacy.

Age-dependent pathogenicity of two severe fever with thrombocytopenia syndrome viruses in a ferret model

This study compares the pathogenicity of two SFTSV genotypes in young and old ferrets, showing that older animals exhibit more severe disease and that viral strain differences have limited impact within the same age group.