Viral Infections and Vectors

The route of infection shapes Rift Valley fever virus pathogenesis, humoral immune response, and horizontal transmission in sheep.

This study compares subcutaneous and intranasal infection routes of RVFV in sheep, showing differences in disease progression, immune response, and horizontal transmission.

Development of a non-invasive diagnostic method for pathogenic RNA viruses using sebum wiped from the cat's body surface

This paper develops a non-invasive method to detect RNA viruses in cats using sebum, demonstrating its effectiveness for FIV and SFTSV detection comparable to blood tests.

P-BODY AND CYTOSKELETON REMODELING BY ORTHOHANTAVIRUSES.

This study uses advanced imaging to analyze how orthohantaviruses alter P-bodies and the cytoskeleton during infection, revealing spatial correlations and degradation patterns of viral RNAs.

Characterization of neural infection by Oropouche orthobunyavirus

This study characterizes Oropouche orthobunyavirus replication in neural cells and brain slices, showing cytokine production and providing a model for studying viral neuropathogenesis.

Oropouche virus infects human neural progenitor cells and alters the growth of brain organoids

This study shows that Oropouche virus infects human neural progenitor cells and brain organoids, causing proliferation arrest and loss of neural rosette organization.

Prolyl tRNA Synthetase Is Required for Mammarenavirus Multiplication

This paper shows halofuginone inhibits mammarenavirus replication by targeting prolyl-tRNA synthetase, leading to translation inhibition and reduced viral budding.

THE LASSA VIRUS FUSION DOMAIN HAS STRUCTURAL PLASTICITY AND EXPLOITS BIS(MONOACYLGLYCERO)PHOSPHATE FOR FUSION

This study investigates the structural plasticity of the Lassa virus fusion domain and its interaction with BMP lipids during membrane fusion.

A lethal mouse model of Oz virus infection reveals hepatic involvement and enables evaluation of antiviral and vaccine efficacy

This study establishes a lethal mouse model of Oz virus infection, revealing hepatic involvement and demonstrating the efficacy of antiviral drugs and vaccines against the virus.

Identification of a novel and divergent reptarenavirus in an Amazon coral snake (Micrurus spixii )

The paper identifies a novel reptarenavirus, ACSV-1, from Amazon coral snake RNA-seq data, showing high divergence from known reptarenaviruses.

Utility of recombinant envelope domain III as a diagnostic antigen for the specific detection of Kyasanur Forest Disease

This paper develops a specific ELISA test for Kyasanur Forest Disease using recombinant envelope domain III protein as an antigen, showing high specificity and sensitivity.

Screening of MMV open-source libraries using Bunyamwera virus as a model reveals inhibitors of Oropouche virus infection

The paper screens MMV libraries against Oropouche virus using Bunyamwera virus as a model, identifying GSK-983 as a promising inhibitor with low EC50 and high selectivity.

A century-old museum sample reveals abandavirus with modern day presence in northernEuropean bats

This study recovers an ancient Bandavirus genome from a 1919 bat sample and identifies its modern presence in European bats, showing its ability to block interferon induction.

Structure and function of the nairovirus cap-snatching endonuclease

This study characterizes the structure and function of nairovirus cap-snatching endonucleases, revealing a unique two-metal-ion mechanism and identifying potent inhibitors.

Characterization of a lethal Crimean-Congo hemorrhagic fever virus infection model in interferon-deficient mice for studies of virus pathogenicity and vaccine efficacy

This study establishes an IFN-deficient mouse model for CCHFV infection to evaluate pathogenicity and vaccine efficacy.

Cell surface localization and intercellular transfer of the hantavirus nucleocapsid protein via a viral assembly-independent mechanism

This study shows that hantavirus N protein localizes on the plasma membrane and is secreted and transferred between cells, independent of viral assembly.

Lrp1 facilitates infection of neurons by Jamestown Canyon virus

This study identifies Lrp1 as a host factor required for Jamestown Canyon virus infection of neurons and shows it is shared by other bunyaviruses.

Specific and versatile monoclonal antibodies for hantavirus research

This paper generates and validates specific monoclonal antibodies against Seoul virus proteins to aid in hantavirus research and drug development.

Pandemic Response Box Screening Identified CRM1/XPO1 as an Anti-Mammarenavirus Druggable Target

The paper screens a compound library to identify anti-mammarenavirus agents, finding CRM1/XPO1 inhibitors as promising therapeutic targets.

Investigation of Powassan virus lineage II pathogenesis and neurotropism in mice

This study investigates POWV lineage II pathogenesis in mice, finding that distinct disease phenotypes arise from genetic variations beyond nonsynonymous mutations.

Human cell line tropism, interferon system interactions and NSs mechanisms by the Ntepes and Gabek Forest phleboviruses

This paper investigates the cell line tropism, interferon system interactions, and NSs mechanisms of Ntepes and Gabek Forest phleboviruses, finding they can infect human cell lines and inhibit the interferon system similar to Rift Valley fever virus.

Identification and genetic characterization of Jingmen tick virus from ticks sampled in select regions of Kenya; 2022-2024

This study identifies and genetically characterizes Jingmen tick virus (JMTV) in Kenyan ticks, revealing positive selection, recombination, and zoonotic potential.

Risk factors, patterns and seropositivity of inter-epizootic Rift Valley fever virus of cattle in northern Tanzania.

This study assesses RVFV seroprevalence and risk factors in cattle in northern Tanzania between 2007 and 2024, identifying age, sex, herd size, water access, and geography as significant predictors.

4'-fluorouridine is a potent inhibitor of Oropouche virus in vitro and in animal infection models

This study shows 4'-fluorouridine inhibits Oropouche virus replication in vitro and in animal models, with no resistant variants observed.

Orthobunyavirus neurovirulence is a complex trait involving all three genome segments

This study identifies that LACV neurovirulence is a complex trait mediated by proteins on all three genome segments, with the M and S segments being primary drivers.

First Sin Nombre virus (Orthohantavirus sinnombreense) genome sequences from the Northwestern United States

The paper reports the first Sin Nombre virus genome sequences from the Northwestern United States and voles, revealing high prevalence and evidence of viral reassortment.

Identification of a novel biological role of arenavirus NP exonuclease (exoN) activity in a safe Pichinde virus model

This study identifies a novel role of arenavirus NP exoN in suppressing IFN-I responses and promoting infectious virion production using a safe Pichinde virus model.

Molnupiravir inhibits Bourbon virus infection and disease-associated pathology in mice

This study shows molnupiravir reduces BRBV infection and disease in mice by lowering virus burden and improving immune and clinical outcomes.

Side-by-side evaluation of two mouse models for Crimean-Congo Hemorrhagic Fever Virus infection.

This study compares two mouse models of CCHFV infection, showing strain-specific disease severity and viral dissemination, supporting their use for antiviral research.

Immunodominant structural proteins Gc and N drive T cell-mediated protection against La Crosse virus

This study identifies T cell responses against La Crosse virus structural proteins Gc and N as critical for protection, showing immunization with these antigens improves survival in vulnerable weanling mice.

SFTSV NSs protein is a novel tick antiviral RNAi response suppressor

This study shows that SFTSV NSs protein is essential for viral replication in tick cells by suppressing the tick's RNAi response through depletion of virus-derived siRNAs.