Pharmacological Receptor Mechanisms and Effects

Extracellular flux analysis and proteomic profiling indicate ibogaine promotes synaptic plasticity and neural repair by a metabolic preconditioning mechanism

This study shows ibogaine induces metabolic preconditioning in neurons, enhancing synaptic plasticity and neural repair through transient metabolic stress and sigma-2 receptor activation.

MD simulations of Human Sigma1 Receptor Trimer Uncovers Cholesterol Dependent Stabilization and Ligand Specific Dynamics

Across 12 µs of all-atom simulations, cholesterol stabilizes the sigma-1 receptor trimer, while haloperidol, unlike (+)-pentazocine, engages β6-strand W136 to tighten interprotomer coupling.

Sigma-1 Receptor Promotes Glycolysis in Neuronal Systems by Suppressing GRIM19

This study shows that Sigma-1 receptor promotes glycolysis in neuronal systems by suppressing GRIM19, affecting NAD+/NADH metabolism and mitochondrial activity.

Neurobiological and Chemical Characterization of the Cyanobacterial Metabolite Veraguamide E

This paper characterizes the cyanobacterial metabolite Veraguamide E, showing it binds the sigma-2 receptor with high affinity, modulates calcium signaling in neurons, and lacks cytotoxicity.

Social and Contextual Memory Impairments Induced by Amyloid-β Oligomers are Rescued by Sigma-1 Receptor Activation

This study shows that activating sigma-1 receptors with PRE-084 rescues synaptic plasticity and memory impairments caused by amyloid-beta oligomers in an Alzheimer's disease model.

Sertraline modulates hippocampal plasticity and learning via sigma 1 receptors, cellular stress and neurosteroids

This study investigates how sertraline affects hippocampal plasticity and learning through sigma 1 receptors, cellular stress, and neurosteroids in rat models.

Sigma Ligand-mediated Cytosolic Calcium Modulation in BV2 Microglia Cells

This study investigates how sigma receptor ligands modulate cytosolic calcium levels in BV2 microglia cells, finding increased calcium levels and extracellular calcium entry with certain ligands.

A novel baseline-effect shift tracking model for more sensitive detection of differences in the effects of closely related dopamine transporter inhibitor/ sigma receptor antagonist drug combinations on psychostimulant use.

The paper introduces a new model, BEST, to detect differences in drug effects on cocaine consumption, finding it more sensitive than existing models in certain contexts.

Highly specific σ2R/TMEM97 ligand alleviates neuropathic pain and inhibits the integrated stress response

This paper identifies FEM-1689 as a σ2R/TMEM97 ligand that alleviates neuropathic pain by inhibiting the integrated stress response in mice and human sensory neurons.

Specific detection and deletion of the Sigma-1 receptor in neurons and glial cells for functional characterization in vivo

This study develops a specific antibody and Cre-dependent conditional KO mouse to detect and delete the Sigma-1 receptor in specific cell types in vivo, revealing its widespread expression in neurons and glial cells.