Discover, rate, and verify biology preprints.

SIN-3 coregulator maintains adaptive capacity to different diets in Caehnorhabditis elegans through vitamin B12

The paper shows that SIN-3 coregulator in C. elegans is essential for adapting to different bacterial diets, specifically through vitamin B12-dependent metabolic pathways.

Evidence for non-optimal codon choice in highly transcribed sex-biased genes of Drosophila melanogaster

The paper shows that non-optimal codons are preferentially used in sex-biased genes of Drosophila melanogaster and are linked to protein disorder.

Combinatorial effects of multiple genes contribute to beneficial aneuploidy phenotypes

This study shows that beneficial aneuploidy phenotypes in yeast arise from combinatorial gene expression changes across multiple chromosomes or chromosomal regions.

Genomic landscape of the medieval Hungarian elite from the Szekesfehervar royal necropolis

The paper analyzes shotgun genomes from the medieval Hungarian elite, revealing homogenization through admixture and identifying a previously unrecognized Conquest-period stratum.

Altered chromatin accessibility and nucleosome positioning landscape upon HDAC and LSD1 inhibition in cancer cell

The paper investigates how HDAC and LSD1 inhibition alters chromatin accessibility and nucleosome positioning in cancer cells, revealing a JunB-mediated mechanism that highlights therapeutic vulnerabilities.

Long-Read Sequencing of the MUC1 VNTR: Genomic Variation, Mutational Landscape, and Its Impact on ADTKD Diagnosis and Progression

This study uses long-read sequencing to characterize MUC1 VNTR variation in ADTKD-MUC1, identifying frameshift mutations and their association with disease progression.

Characterization of a C9orf72 Knockout Danio rerio model for ALS and cross-species validation of potential therapeutics screened in Caenorhabditis elegans.

The paper develops a zebrafish C9orf72 knockout model for ALS, identifies pizotifen malate as a potential therapeutic, and validates its efficacy in both zebrafish and C. elegans models.

Germline sequence variation within the ribosomal DNA is associated with human complex traits

The paper identifies rDNA sequence variants associated with human traits using UK Biobank data, finding enrichment in body size traits within the 28S rRNA Expansion Segment 15L region.

The Genomic Legacy of the Norman Conquest in Rural England

This study analyzes ancient DNA from a rural English cemetery to explore genetic continuity and change following the Norman Conquest, finding no genome-wide discontinuity.

Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleep

The paper identifies cell-type-specific genes regulating sleep by mapping GWAS variants to effector genes in human and Drosophila models, revealing ruby/AP3B2 as a conserved glial regulator.

Ultra-large targeted DNA integrations in primary human cells

This paper identifies methods to achieve ultra-large DNA integrations (>10 kb) in human cells with high efficiency using optimized templates and delivery strategies.

Establishment of a Congenic Strain for the Oyster Mushroom Reveals the Structure and Evolution of Mating-Type Loci

The paper develops a congenic strain of Pleurotus ostreatus by introgressing mating-type loci from one strain into another, revealing the multiallelic structure of these loci and their genomic organization.

Asymmetric subspecies-selection of an NLR-TF immune module and reconstruction of broad-spectrum disease resistance in rice

The paper identifies an NLR-TF immune module in rice that confers disease resistance and shows how subspecies-specific selection affects its function and yield.

From low to high transmission: Diversity-dependent responses of Plasmodium falciparum population structure to transmission intensity

This study uses a stochastic agent-based model to show how Plasmodium falciparum population structure responds to transmission intensity and initial diversity, revealing nonlinear patterns in recombination and haplotype dynamics.

Heterologous expression of the human cohesin complex in Saccharomyces cerevisiae results in a dominant-negative phenotype

This study shows that human cohesin cannot function in yeast and disrupts endogenous cohesin biology when expressed heterologously.

Somatic DNA methylation heterogeneity predicts extreme transgenerational epimutation hotspots in Arabidopsis

The paper identifies somatic DNA methylation heterogeneity in Arabidopsis leaves and links it to transgenerational epimutation hotspots.

Graph transformer for ancient ancestry inference

ARGMix uses a graph transformer to infer local ancestry from ancient DNA, showing continuity between Otzi the Iceman and present-day Europeans.

DNA replication errors drive genome-wide small inverted triplication dynamics

The paper identifies DNA replication errors as a source of small inverted triplication (SIT) structural variants in yeast, showing their formation mechanism and characteristics.

Exploratory 16S rRNA Metagenomic Analysis of Soil Microbial Communities in Agroecosystems of North-Central Argentina

The paper conducts a 16S rRNA metagenomic analysis of soil samples from agroecosystems in North-Central Argentina, identifying dominant bacterial phyla and analyzing agronomically relevant genera.

The Y chromosome gene draupnir reveals constraints on engineering Y-linked sex-ratio distorters in malaria mosquitoes

The paper identifies the Y-linked gene draupnir in Anopheles gambiae, showing it escapes transcriptional silencing during spermatogenesis and is necessary for Y-chromosome-based sex-ratio distortion.