H. Kim

This study shows that MGMT genomic rearrangements cause TMZ resistance in gliomas and can be detected in exosomes as potential recurrence markers.

This study identifies marrow adipogenic lineage precursors (MALPs) as critical regulators of osteoclastogenesis through RANKL expression, showing their role in both normal bone remodeling and pathologic bone loss.

The paper integrates multi-omic data from gliomas to show that epigenetic instability and transcriptional disruption are linked to tumor aggressiveness and environmental stress response.

This study uses multiomics analysis of LGSOC cell lines to identify therapeutic vulnerabilities and biomarkers for MEK inhibitor efficacy.

This study examines how accumulated doses affect radio-photoluminescence glass dosimeters (RPLGDs) under different photon energies and irradiation conditions.

This paper identifies a dual-mechanism antibiotic, SCH-79797, that kills Gram-negative and Gram-positive bacteria with low resistance and outperforms combination treatments.

The paper shows that the non-signaling complex formed by Activin A and ACVR1 reduces disease severity in FOP by tempering heterotopic ossification.

This study investigates whether XMAP215 and γ-tubulin synergize in microtubule nucleation and finds they act additively, not synergistically, in purified solutions.

This study identifies SDE2's role in stabilizing the TIMELESS-TIPIN complex to protect stalled replication forks and maintain genomic integrity.

This study shows irisin directly promotes osteoclast differentiation and bone resorption in vitro and in vivo, suggesting it regulates bone remodeling beyond its effects on osteoblasts.

This paper introduces DNA micro-disks with index and WORM memory features to improve DNA-based data storage reliability and accessibility.

The paper engineers Hsp104 variants with substrate specificity to selectively reduce alpha-synuclein toxicity in a Parkinson's disease model.

This study investigates how varying PMA concentrations and durations during THP-1 differentiation affect proteomic signatures and cytokine gene expression in macrophage-like cells.

The paper identifies YejM as a metalloenzyme with phosphatase activity that facilitates cardiolipin translocation, revealing a new functional role in bacterial outer membrane remodeling.

This study shows that deleting or inhibiting OCA-B in T cells protects mice from type-1 diabetes by reducing autoreactive CD8+ T cells and inducing anergy in CD4+ T cells.

This study enhances CRISPR-Cas12a specificity by using a chimeric DNA-RNA guide, reducing off-target mutations in genome editing.

This paper integrates transcriptomic data from nine CKD entities to delineate their molecular differences and identify potential therapeutic targets.

This study identifies RNF125's role in regulating HDAC2 and PDX1 to influence pancreatic cancer development and patient outcomes.

The paper characterizes E. coli promoters and regulatory elements using a genomically-encoded assay, identifying 2,228 promoters and 3,317 regulatory elements, but finds predicting promoter activity from sequence remains challenging.

This study shows APOBEC3A promotes tumorigenesis in mice and supports its role in causing mutations in human cancers.

This study investigates the conformational dynamics of yeast mitochondrial transcription initiation using single-molecule techniques, revealing dynamic transitions and backtracking behavior.

This study shows that copy number profiles are conserved in patient-derived xenografts (PDXs) through engraftment and passaging, indicating minimal impact from the mouse host on tumor evolution.

This study shows that extrachromosomal DNA amplification of oncogenes is common in human cancers and is associated with worse patient outcomes.

This study shows that RdRp speed and fidelity are not the only factors determining recombination efficiency in poliovirus, highlighting additional biochemical properties involved.

This study identifies and characterizes noncoding mutations in pediatric cancers using a computational framework and experimental validation, revealing their role in deregulating cis-regulatory landscapes.

This study shows that a high-phytate/low-calcium diet causes crystal nephropathies, renal phosphate wasting, and bone loss in rats through tubular dysfunction and altered mineral absorption.

PATTIE enables exploratory spatial-semantic information retrieval in biomedical literature through an interactive system and software tools.

The paper identifies lineage-restricted metabolic identities in normal mammary epithelial cells and links them to breast cancer metabolic heterogeneity.

This paper demonstrates the feasibility of using PET imaging to track 89Zr-DFO-labeled CAR T-cells in vivo, showing their distribution and migration over time.

The paper shows that succinate from commensal bacteria promotes tuft cell development and reduces ileal inflammation in a mouse model of Crohn's disease.