J. Liu

The paper introduces deep-APQ, a proteome quantitation method using segmented MS/MS acquisition of a1 ions, showing improved coverage and accuracy in E. coli proteome analysis.

The paper characterizes the Piks allele of the rice immune receptor Pik, showing it does not recognize known AvrPik effectors of the rice blast fungus, suggesting a novel recognition mechanism.

This paper identifies FcγRIIB-mediated capture of antibody-coated bacteria by liver sinusoidal endothelial cells as a mechanism for superior vaccine efficacy.

The paper examines how geochemical gradients affect the functional potential of microbes in Lac Pavin, finding that CPR bacteria and phages show less gene content differentiation by depth compared to other microbes.

This study identifies TWD1 as an ER-actin adapter that links myosin XI-K to auxin transport, explaining defects in ABCB biogenesis and plant development.

The paper identifies the re-emergence of SADS-CoV in pigs in Guangxi, China, through qPCR and metagenomic analysis, suggesting undetected circulation since 2019.

This study shows that a BR-binding-deficient BRI1 mutant is internalized similarly to wild-type BRI1, suggesting parallel endocytic routes and non-canonical functions.

This study identifies aCcr1, an archaeal transcription factor, and its viral homologs as regulators of cell cycle progression, showing they control cell division by repressing cdvA expression.

This study identifies MsGOBP2 and MsOR3 as molecular factors mediating Z11-16: Ald-induced host-feeding preference in Mythimna separata larvae.

The paper identifies non-ACE2 blocking neutralizing antibodies in COVID-19 patients using deep RNA sequencing and molecular dynamics simulations, showing their potential for personalized therapy.

The paper identifies two substrate-binding sites in pOmpT that enable specific cleavage of human AMP RNase 7, revealing structural basis for substrate specificity and drug development clues.

This study identifies two switchable Rac1 pools in Drosophila border cells that integrate direction and coordination during collective migration.

The paper shows that actin filaments and membrane compression from synaptic vesicle exocytosis drive ultrafast endocytosis at synapses.

This study shows that the adipose-neural axis contributes to cardiac arrhythmias through leptin-induced activation of sympathetic neurons and subsequent effects on cardiomyocytes.

The paper investigates how crowding in developing mouse kidney tubules creates mechanical stresses in nephron-forming niches, revealing how spatial constraints influence branching and nephron formation.

This study reports ploidy variation and spontaneous haploid-diploid switching in 500 clinical Candida glabrata isolates, revealing differences in morphology, antifungal susceptibility, virulence, and gene expression.

This study examines the evolution of myxoma virus in Australian rabbits through experimental infections, revealing diverse virulence phenotypes and suggesting selection for transmissibility over inflammation.

This study identifies a DRB1*03:01-encoded epitope that drives a lupus-like transcriptome and cellular aberrations in macrophages, revealing a noncanonical mechanism of HLA-disease association in SLE.

This study uses cryo-ET to show that the Dot/Icm T4SS assembles during the transition from large to small cell variants in Coxiella burnetii.

This study identifies PgfA as a periplasmic protein essential for asymmetric polar growth in mycobacteria by coordinating lipid trafficking and cell wall synthesis.

This study identifies pyroptosis as the main cause of CD4 T cell loss in acute SIV infection in rhesus macaques, with IFI16 upregulation linked to viral loads and cell depletion.

This study identifies Pcr2 as a critical protein for movement and invasion in Toxoplasma gondii, showing that its absence impairs egress and tissue destruction.

This study tracks white matter changes in SIV-infected rhesus monkeys with and without cART, finding early alterations at 4 weeks and varying cART effects over time.

This study shows that reducing CTPS in the fat body of Drosophila alleviates HFD-induced obesity by decreasing lipid storage and TAG levels.

This study identifies a phospho-switch mechanism involving ALK1 and ABCG36 that prioritizes defense-related transport over growth in Arabidopsis.

This study shows Hsp27 binds phosphorylated Tau to prevent its aggregation and mitigate AD pathology.

This study identifies Slamf9+Spp1+ macrophages in hamsters that promote SARS-CoV-2 clearance and inflammation resolution through spatial transcriptomics and scRNA-seq.

This study engineers macrophages to inducibly secrete TRAIL in response to the tumor microenvironment, showing improved anti-tumor effects and reduced side effects in preclinical models.

The paper identifies maternal and embryonic signaling-driven differentiation of luminal epithelial cells in the mouse endometrium and shows conservation in humans.

This paper shows that teicoplanin inhibits SARS-CoV-2 cell entry by blocking cathepsin L proteolytic activity, effective against multiple variants with IC50 values of 2.038 M and 2.116 M.