W. Zhao

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

This study shows membrane curvature regulates Piezo1 distribution in live cells, with Piezo1 depletion from curved protrusions and enrichment in invaginations, and activation reduces filopodia formation.

The paper isolates a novel thermophilic bacterium from a deep-sea hydrothermal vent and identifies it as part of a deep-branching clade that provides insights into early bacterial evolution.

MADET is a manually curated database that compiles 453 microbiota-drug associations from 24 papers to aid in understanding microbiota's role in anticancer drug efficacy and toxicity.

The paper shows mechanical forces from surrounding tissue activate mitochondrial energy metabolism during cell differentiation in Drosophila.

This study identifies multiple recombination events between SARS-CoV-2 Omicron subvariants and other variants, suggesting co-infection and recombination drive viral evolution.

This study shows that FeoB1 is critical for C. difficile toxin production and virulence, suggesting it as a therapeutic target for CDI.

The paper uses cryo-electron tomography to visualize the native architecture of the kinetochore-microtubule interface in human cells during mitosis, revealing distinct structural features.

This study shows that combining fecal microbiota transplantation with anti-PD-1 therapy improves survival and tumor control in mice, with specific gut bacteria and metabolites contributing to the enhanced efficacy.

This paper uses nanopillar arrays to quantify subnuclear morphology in tumor cells, showing it correlates with malignancy and drug response.

This study shows that Numb is essential for skeletal muscle function, as its knockout reduces force, alters mitochondrial structure, and affects calcium dynamics in mice.

This study shows that TCDD disrupts the induction of klf9 by thyroid hormone and glucocorticoids in frogs, revealing AHR-mediated mechanisms in metamorphosis disruption.

This study identifies DDX18 as a negative regulator of IRF3 binding to the IFN-β promoter, suppressing type I IFN production during viral infection.

This paper develops a mouse model for studying islet transplantation tolerance by creating a congenic line that allows controlled diabetes induction and assessment of islet engraftment.

This study investigates the oligomerization of FliF domains in Salmonella typhimurium, revealing how RBM1, RBM2, and RBM3 contribute to the assembly of the MS ring through domain interactions.

This study shows drought reduces sucrose transport from cottonseed coat to fiber and disrupts sucrose allocation, leading to decreased cellulose synthesis and fiber strength.

This paper introduces a high throughput single-cell pipeline for bispecific antibody discovery, demonstrating its efficiency in identifying rare functional clones and uncovering design principles for improved immunotherapeutics.

This study screens FDA-approved compounds and natural products to identify inhibitors of microsporidia infection in C. elegans, finding five compounds that block spore firing and one that slows infection progression.

The paper screens cell-virus and cell-cell interactions across multiple species to identify potential hosts and co-evolution patterns of viruses including SARS-CoV-2.

This study compares the in vitro efficacy of four oxazolidinones against rapid-growing Mycobacteria isolates from Beijing, finding tedizolid most effective against M. abscessus and delpazolid against M. fortuitum.

The paper uses single-cell transcriptomics to profile viral receptor expression in masked palm civets, identifying potential tissue tropisms for 132 viruses.

This paper improves image resolution and signal-to-noise ratio in live cell imaging using a combination of discrete wavelet transform and Lucy-Richardson deconvolution.

This study shows that the hexapeptide WKYMVm promotes M2 macrophage polarization via the JAK1/STAT6 pathway, enhancing angiogenesis in bone repair.

This paper introduces MOSAICA, a spatial transcriptomics technology that combines spectral and lifetime encoding with machine learning to enable highly multiplexed in situ biomarker profiling.

This study shows that transient nuclear deformation enhances cell reprogramming by altering epigenetic states, specifically reducing DNA methylation and H3K9 methylation.

This paper shows that microvesicles transfer mitochondria to brain endothelial cells and neurons, increasing ATP levels under ischemic conditions, while exosomes do not affect mitochondrial function.

This study develops AIM-CICs, an AI-based method using CNN to automatically identify and classify cell-in-cell structures, improving efficiency and accuracy over manual methods.

This study identifies C28 as a compound that modulates IKs channel voltage sensor activation, reversing drug-induced APD prolongation without affecting normal APD.

This study shows RAD51AP1 binds nucleosomes and aids RAD51 in chromatin-mediated DNA repair by facilitating donor DNA capture and joint-molecule formation.