biophysical modeling

This study investigates how horizontal gene transfer of a squalene-hopene cyclase enables lipid metabolism rewiring in fission yeast, allowing adaptation to anoxic environments.

This study investigates urinary free oligosaccharides and microbial gene capacity for glycan digestion in women with and without overactive bladder syndrome.

The paper identifies master regulatory miRNAs in glioblastoma and develops a therapeutic delivery method to inhibit tumor growth.

This study determines the structure of PP2A/B55 inhibited by IER5-N50 and shows its role in suppressing pTau dephosphorylation and KRT1 expression.

This study identifies ARHGAP12 as a regulator of the paracellular leak pathway by suppressing F-actin assembly at tight junctions without affecting ion flux.

The paper discovers five new viruses in black soldier flies and develops molecular tools for viral surveillance.

This study identifies a non-canonical receptor-like mechanism where CTR1 clusters on the plasma membrane in response to copper, modulating membrane properties to facilitate endocytosis.

The paper identifies LyLAP as a key enzyme for lysosomal degradation of transmembrane proteins, showing its role in maintaining endocytic activity and lysosomal stability in pancreatic cancer.

The paper models cell migration by coupling polarity cues to actin dynamics, showing how long-range inhibition stabilizes motility and explains cellular dynamics.

This study identifies a new class of OLD family ATPases in archaea, showing Cran1 is essential for cell cycle progression rather than antiviral defense.

This paper characterizes the structure and dynamics of HSPB1 oligomers using biophysical and computational methods, revealing conformational heterogeneity and domain-specific interactions.

This study identifies cross-reactive vaccine antigens in Gram-positive ESKAPE pathogens using subtractive proteome analysis and opsonic activity testing.

This study shows PCL proteins phase-separate to form PRC2 condensates, regulated by CpG islands disrupting their intramolecular interactions.

The paper identifies sequence determinants of ABHD12 enzymatic activity through bioinformatics and biochemical validation, and identifies a Drosophila ortholog with lyso-PS lipase activity.

This study identifies the Cia1-Cia2 interface as critical for recognizing TCR motifs on client proteins, revealing a broader role for CIAO2A in iron-sulfur protein maturation.

This study identifies RAB5c's role in regulating non-canonical autophagy machinery to enhance phagosome maturation and microbial killing by macrophages.

The paper investigates how EnvZ signal output relates to transmembrane water encapsulation and helix dynamics in Gram-negative bacteria.

The paper identifies 10 unique proteins in Mycobacterium abscessus with restricted evolutionary variation and atypical amino acid composition, suggesting their essential role in human infections.

This paper identifies atazanavir as a pan-positive allosteric modulator that activates multiple Family A GPCRs and sustains G protein signaling through non-canonical mechanisms.

The paper investigates thyroglobulin phase separation in thyroid follicles, showing it forms storage depots and reveals a mechanism for hormone homeostasis.

This study shows that AmgK, a peptidoglycan kinase in Legionella pneumophila, is essential for intracellular survival and replication in host macrophages, highlighting its role in pathogenicity and potential as a drug target.

This study shows that CTIP and biophysical models overpredict heat risk, as healthy adults maintained heat balance across extreme heat conditions.

This study analyzes the draft genome of Streptomyces sp. IICT-RSP475, identifying 18 biosynthetic gene clusters, including two novel RiPP-like clusters, and confirms its classification as a new Streptomyces species.

The paper identifies aggregation as the cause of low splicing efficiency in a cysteine-less split intein and presents a rationally engineered variant with high activity.

This study identifies GB, DMG, and sarcosine as both osmoprotectants and carbon sources for Vibrio natriegens, revealing their dual roles in osmotic stress response and nutrient utilization.

The paper identifies a plant immune receptor, SCORE, that recognizes CSP peptides and shows polymorphisms across species, enabling the design of synthetic variants for broad pathogen detection.

This study shows that the Panx11-89 mutant forms a functional ATP release channel independently of wild-type Panx1, with conserved structure-function features and sensitivity to inhibitors.

This paper develops T-SenSER, a synthetic biosensor for T cells that enhances anti-tumor responses by sensing TME factors like VEGF and CSF1, showing improved efficacy in lung cancer and multiple myeloma models.

This study shows that mechanical interfacial tension between oncogenic and wild-type cells determines tissue-specific tumor formation in mammary and bronchial epithelia.

This study shows that nutrient availability limits antibiotic efficacy in structured bacterial populations by creating a traveling death front, which can be overcome or exacerbated by nutrient supply changes.