MicroRNA in disease regulation

The paper defines tumor suppressor microRNAs requiring genetic/epigenetic inactivation and anti-tumorigenic activity, finding miR-34a does not meet these criteria.

This study examines miR-155 and Let-7c expression in Down syndrome individuals and finds Let-7c overexpression linked to early cognitive impairment, while miR-155 correlates with lipid metabolism changes in adults.

This study investigates the in vivo role of the 3' non-seed region in let-7a microRNA, showing its importance in target repression and distinguishing let-7a from its paralogs.

SPOROS is a pipeline that analyzes 6mer seed toxicity in small RNA sequencing data by focusing on the seed region of sRNAs bound to RISC.

This study uses single-molecule imaging to visualize miRNA-mediated gene silencing in cells, revealing miRNAs bind to translated mRNAs and induce repression and decay within 30-60 minutes.

This study identifies miR-138-5p as a regulator of short-term memory and inhibitory synaptic transmission in hippocampal interneurons, with implications for schizophrenia.

The paper shows that flexible pri-miRNA structures enable the production of 5' isomiRs through alternative Drosha cleavage, influenced by RNA-binding proteins in cancer.

scanMiR predicts microRNA targets using a biochemical model and k-mer affinity, offering tools for binding site scanning, affinity estimation, and repression prediction.

This study shows that miR-9a regulates rhomboid mRNA and protein levels in Drosophila embryos by promoting mRNA degradation and inhibiting translation.

The paper identifies the RPAP3-TRBP interaction and shows the HSP90/R2TP chaperone complex's role in dsRNA pathways by binding TRBP and affecting AGO and Dicer function.

This study benchmarks small RNA-sequencing methods for miRNA quantification in biofluids, finding no single method outperforms others and highlighting protocol-specific biases.

The paper shows miR-10b interacts with U6 snRNA, altering splicing and affecting cell viability through changes in CDC42 isoforms and levels.

The paper curates a comprehensive reference of miRNA expression across 196 human primary cell types using public datasets and provides access through a UCSC Genome Browser track and R/Bioconductor package.

The paper presents M3Cs, a curated resource of miRNA studies in pediatric cancers, linking research to clinical and drug domains through data-driven approaches.

This study shows that TUT4/7 regulate miRNA variants in a cell-type-specific manner, affecting cancer cell properties and miRNA-mRNA networks.

The paper identifies miR-320a as a regulator of the unfolded protein response by analyzing TSS-miRNA targets in colorectal cancer cells using AGO-qCLASH.

The paper identifies rare, highly abundant miRNAs in mammalian oocytes that resist dilution and efficiently suppress gene expression, supporting the stoichiometric hypothesis.

The paper introduces CSmiR, a method to identify cell-specific miRNA-mRNA regulatory networks using single-cell co-sequencing data, revealing unique miRNA regulation in individual cells.

The paper identifies five miRNAs associated with bone mineral density in healthy adult baboons, suggesting their role in normal aging and potential disease mechanisms.

The paper introduces MapToCleave, a method to profile miRNA biogenesis in living cells, showing that stable lower basal stems enhance processing and expression across species.

The paper identifies five diabetes-associated genes upregulated in SARS-CoV-2-infected pancreatic tissue and hypothesizes that miRNA competition between viral and host genes contributes to diabetes exacerbation in COVID-19.

This paper identifies therapeutic miRNA cocktails for Ewing Sarcoma using a network science-based approach to prioritize miRNA targets and combinations.

miRbiom uses Bayesian causal networks of RBP-miRNA interactions to predict miRNA profiles with high accuracy without requiring separate miRNA profiling experiments.

The paper shows that microRNA-182/microRNA-183 repress Ago2 to maintain pluripotency in mESCs, revealing a regulatory circuit involving microRNA machinery.

CancerMIRNome provides an interactive database for analyzing and visualizing miRNA expression data from cancer studies to identify dysregulated miRNAs and develop biomarkers.

This study develops a genetic tool to reversibly inhibit miRNA-mediated gene repression in vivo and shows tissue-specific dependencies on miRNA function for homeostasis and regeneration.

The paper investigates cis regulation of viral microRNA clusters in KSHV, showing that specific pre-miRNAs influence the expression of the entire cluster and can be targeted to inhibit miRNA production.

The paper identifies non-redundant microRNAs in breast cancer subtypes and links them to cancer-related biological functions through co-expression networks.

This study uses high-throughput miRNA-sequencing to analyze miRNA expression in first and third trimester human placentae, identifying differentially expressed and stable miRNAs across gestation.

The paper identifies miR-124's role in promoting neuronal maturity by enhancing target gene expression through interaction with ELAVL3.