Mitochondrial Function and Pathology

This study creates an Msp1-protease chimera to capture transient AAA+ interactions, identifies Ost4 as a novel Msp1 substrate, and reveals mislocalization errors in Ost4.

The paper shows that the volume of mitochondria inherited by daughter cells in budding yeast affects mtDNA homeostasis, with reduced mitochondrial volume increasing mtDNA loss and requiring copy number upregulation to maintain function.

The paper investigates the role of COX6B1 in cytochrome c oxidase assembly, finding it essential for both early redox-sensitive steps and late stabilization of the complex.

This study identifies mitochondrial dysfunction in neurons and glia as an early driver of neurodegeneration following traumatic brain injury, linking it to Alzheimer's disease pathology.

This paper introduces an algebraic framework to model mitochondrial dynamics as groupoids and defines a distance metric for comparing mitochondrial structures based on morphological operations.

This study shows that sphingolipid metabolism influences mitochondrial morphology changes in aging yeast cells and during oxidative stress.

This study investigates the distinct roles of VDAC1, VDAC2, and VDAC3 in mitochondrial respiration and cancer cell metabolism through isoform-specific knockouts in HeLa cells.

This study shows that AOX from Ciona intestinalis accelerates Drosophila larval growth and development by reconfiguring the mitochondrial ETS without increasing body heat.

This study identifies MRPL47 as an amplified and overexpressed gene in NSCLC that promotes tumor progression by disrupting mitochondrial function and ROS signaling.

The paper uses single-cell and bulk RNA sequencing to compare pathological and physiological cardiac hypertrophy, finding that mitochondrial fission genes drive pathological progression.

This study shows that disrupting mitochondrial fission (DRP1) leads to liver injury and tumorigenesis, while loss of fusion proteins has less impact, and triple knockout mice show reduced tumor development.

This study shows EFhd2 promotes mitochondrial spare capacity in B cells during immune synapse formation by stabilizing microtubules.

This study investigates how germline and somatic genetic variations affect mitochondrial DNA content, mutation patterns, and gene expression in liver tumors across four mouse strains.

This study shows that stressed astrocytes can restore mitochondrial function through fusion with mesenchymal stromal cells, as evidenced by mitochondrial DNA transfer and long-term functional recovery.

The paper introduces a framework to quantify mitochondrial specialization and plasticity using transcriptomic data across various contexts.

This study identifies Mdm38/LETM1 as a protein that links ion homeostasis and proteostasis in the mitochondrial inner membrane in yeast.

This study examines mitochondrial changes during atrial fibrillation in animals and humans, showing early hyperfunction and damage, and demonstrates that mitochondrial-targeted therapy can prevent adverse remodeling and AF sustainability.

This study shows that reduced Opa1 in endothelial cells of old mice worsens vascular function and increases kidney oxidative stress.

This study shows that mitochondrial dysfunction in monocytes of severe alcohol-related hepatitis patients contributes to immune deficiency.

The paper identifies NHR-180 as a regulator of mitochondrial function and protein synthesis that can restore mitochondrial function in atfs-1(null) worms and mammalian models.

This study identifies bi-allelic XPNPEP3 variants causing mitochondrial disease with pediatric cardiomyopathy, revealing impaired mitochondrial protein processing as the underlying mechanism.

This study shows Fis1 depletion reduces dendritic mitochondrial length and alters mitochondrial function, leading to increased calcium levels and changes in dendritic branching and spine density.

This study shows that an inherited mtDNA mutation alters inflammatory cytokine responses in macrophages and in vivo, leading to increased IFN-I and reduced pro-inflammatory cytokines.

The paper quantifies mitochondrial structure-function heterogeneity, identifying redox-tuned small-mitochondrial-networks that specify stemness and are detectable in patient transcriptomes.

This study compares mitochondrial remodelling in humans after moderate-intensity continuous exercise and sprint-interval exercise, showing divergent adaptations in mitochondrial structure, function, and protein expression.

The paper maps tissue-specific mtDNA heteroplasmy and its associations with age and mtDNA gene expression using bulk RNAseq data from GTEx.

The paper shows that platelet mitochondrial bioenergetics correlate with skeletal muscle mitochondrial function in mice, suggesting platelets as a non-invasive surrogate for muscle metabolism assessment.

The paper identifies a distinct bioenergetic profile of synaptic mitochondria that enables them to adapt to the dynamic energy demands of synaptic transmission.

This study investigates triclosan's effects on mitochondrial form and function in Xenopus laevis tadpole brains, finding dose-dependent impairments in mitochondrial membrane potential and metabolic function.