Mitochondrial Function and Pathology

The paper shows EGF induces mitochondrial fission and calcium-dependent transport via Myo19 to support filopodia extension in A431 cells.

This paper develops a non-planar perylene diimide compound that targets both mitochondrial membrane potential and mtDNA transcription, showing antitumor effects in breast cancer models.

This study compares fibroblast metabolism across species, finding spiny mice and rabbits exhibit a glycolytic preference and oxidative stress resilience across lifespan.

This study identifies BLTP1 as a mitochondrial phospholipid transporter that prevents lipid overload and apoptosis by exporting phospholipids via FKBP8-tethered ER-mitochondrial contacts.

The paper identifies COX7A as a regulator of cardiac polyploidy by modulating mitochondrial integrity, showing opposing roles in heart and salivary gland tissues.

The paper validates a method to quantify 3D mitochondrial network morphology in mouse skeletal muscle and applies it to terminal Schwann cells, showing increased fragmentation in dystrophic muscle.

The paper identifies a tissue-specific mitochondrial isoform of MFN2 generated by non-coding exon splicing and shows its distinct functional role in lipid trafficking.

This study quantifies TCA cycle intermediates in mouse ocular tissues to reveal tissue- and sex-specific mitochondrial metabolism and diurnal variations.

This study examines how nutrient environments affect MRPL44-deficient cardiomyocytes, revealing distinct metabolic responses in glucose vs. lipid-rich conditions that contribute to mitochondrial hypertrophic cardiomyopathy.

This study shows that PI5P causes mitochondrial fragmentation and dysfunction in cardiomyocytes under metabolic stress, linking endolysosomal signaling to mitochondrial metabolism.

This paper uses physics-informed neural networks to reconstruct mitochondrial proton motive force from surrogate signals, achieving high accuracy and revealing feature contributions under different oxygen conditions.

This paper identifies bi-allelic AMPD2 variants as a cause of Leigh syndrome, showing they lead to complex V assembly defects and cytosolic purine imbalance.

This study shows that hematopoietic stem cell conditioned media induces excessive mitochondrial fission in colorectal cancer cells via Drp-1, leading to apoptosis and loss of viability.

This study identifies BASP1 as a Ca2+-CaN-regulated protein that links actin dynamics to mitochondrial fission, essential for neurite outgrowth and neuroprotection.

This study shows that mitochondrial redistribution and activity are crucial for apical constriction in Drosophila gastrulation, regulated by the Dorsal signaling pathway.

This study shows that proteostatic stress in mitochondria impairs mitoribosome biogenesis and translation, leading to respiratory deficiency and mitochondrial DNA loss.

This study shows meclizine improves cardiac function and mitochondrial structure in a mitochondrial disease model without relying on ATP or glycolysis.

This study investigates RNA import into yeast mitochondria using synthetic biology and adaptive laboratory evolution, finding that mRNA import remains undemonstrated despite existing short RNA import mechanisms.

The paper investigates how mitochondria near synapses remodel to increase ATP production and support synaptic plasticity through structural and functional changes.

This study shows that Tafazzin-mediated cardiolipin remodeling is essential for metabolic stress response and effector function of inflammatory T cells, with implications for Barth syndrome.

This paper shows that renalase activates mitochondrial leak metabolism to enhance protein synthesis and protect cells from stress and injury.

This study shows that mutant CHCHD10 causes mitochondrial dysfunction and cardiomyopathy by disrupting cytochrome c oxidation and activating retrograde signaling.

This study identifies FATE1 as a mitochondrial fusion-promoting factor that antagonizes fission and protects against fragmentation under cytotoxic stress.

The paper tests optimization strategies for isolating mitochondria from rat liver tissue but finds that modifications do not significantly improve mitochondrial quality.

This study shows that mtDNA mutations in mice lead to metabolic dysfunction in the retina and RPE, impairing retinal function through altered energy metabolism and glucose transport.

This study identifies MNP33, a novel mitochondrial microprotein, and shows it regulates bioenergetics, lipid metabolism, and stress responses by interacting with ANT2 and modulating mitochondrial function.

The paper shows that saturated lipid stress reduces mtDNA synthesis in human cells by disrupting ER-mitochondria contact sites and fatty acid trafficking, which is reversed by monounsaturated fatty acids.

The paper develops a computational model to estimate mitochondrial transplantation doses for barrier-limited tissues, finding route-adjusted requirements differ from cardiac estimates.

This paper shows that NDUFS2 in mitochondrial Complex I is critical for oxygen responsiveness in human DASMCs, affecting calcium, cell shortening, and mROS without altering respiration.

This paper develops a quantitative systems pharmacology model to study mitochondrial metabolism in heart failure and predicts how changes in metabolic pathways affect exercise capacity.