Circadian rhythm and melatonin

This study uses Mendelian randomization to identify genetic links between chronotype and brain volume differences outside the suprachiasmatic nucleus in the UK Biobank.

This study shows environmental circadian disruption rewrites liver circadian gene expression rhythms, affecting metabolism, and these changes persist after recovery.

The paper identifies 8 functional subtypes of rodent ipRGCs and shows they have distinct photosensitivity and response timing, with varying performance under different light conditions.

This study shows that loss of functional dpCry1 in monarch butterflies disrupts circadian eclosion and flight activity rhythms, but not temperature entrainment, indicating a unique role for dpCRY1 in light entrainment.

TW68, a Cryptochrome stabilizer, reduces fasting blood glucose in diabetic mice by enhancing CRY stability and decreasing gluconeogenic gene expression.

This study shows fetal circadian rhythms develop early in pregnancy and synchronize with the maternal rhythm, influenced by maternal glucocorticoids.

This study uses single-cell time-lapse microscopy to show that RpoD4 pulses at cell division and links the circadian clock and cell cycle in Synechococcus elongatus.

The paper identifies a new vascular portal pathway from the SCN to the OVLT, showing circadian-regulated blood flow and AVP transport, suggesting a mechanism for circadian signaling.

The paper investigates how Bmal1 rescue and time-restricted feeding affect liver and muscle proteomes in mice, finding BMAL1 has a greater impact than feeding cycles.

This study tests a home-based protocol for measuring circadian phase via salivary DLMO, showing feasibility and accuracy in 10 participants.

The paper identifies circadian gene expression patterns in Drosophila using single-cell and bulk RNA-seq, revealing three mechanisms for generating daily gene expression rhythms.

This study examines circadian genetic architecture in fibroblasts to assess its contribution to bipolar disorder risk, finding limited gene expression patterns and no significant genetic associations with BD.

The paper defines and analyzes two types of amplitude-period correlations in circadian rhythms and shows their impact on oscillator-environment interactions.

The paper identifies robust ~12h transcriptional rhythms in human peripheral white blood cells under free-living conditions, showing homology to circatidal gene programs in marine species.

Kronos is an R-based tool for analyzing circadian rhythms in biological datasets, supporting complex study designs and high-dimensional omics data.

The paper shows that light affects eclosion and locomotor activity in Drosophila through distinct sensory pathways.

This study shows that gradual exposure to a fragmented day-night cycle induces reversible circadian arrhythmia in mice.

This study investigates the role of lin-42 and kin-20 in the circadian clock of C. elegans using a bioluminescence reporter, showing they regulate the period length through neuronal cells.

The paper identifies synaptic protein alterations and circadian rhythm disruptions in brain regions associated with opioid use disorder using proteomics.

The paper examines time-of-day-dependent transcriptome and metabolome variations in human NAFL and NASH livers, finding disruptions in rhythmic gene expression and metabolites.

This study shows that terminal uridylation of mRNA is rhythmic in mouse liver and that knocking down TUT4 and TUT7 disrupts circadian rhythms.

This study shows that human CLOCK has extra-circadian functions in the neocortex, enhancing cognitive flexibility and neural connectivity through altered gene expression in excitatory neurons.

The paper identifies a leptin-responsive hypothalamic circuit that influences circadian feeding rhythms by modulating SCN activity and food entrainment.

This study shows that Bmal1 and Per2 in the nucleus accumbens reduce alcohol consumption in male mice, but not in females, with Bmal1's effect being specific to the nucleus accumbens in females.

This study shows coupling enables robust circadian rhythms in redox oscillators despite noise and heterogeneity.

Browser-based cosinor fitting for circadian and ultradian rhythms with no install; 24-hour results matched two existing programs, ultradian results diverged slightly from one of them.

The paper shows that timed activation of VIP neurons in the SCN and late afternoon light exposure can rescue dysregulated estrus cycles in mice.

This study identifies a novel circadian feedback loop between Per1 and Per2 genes in CA1 that mediates mood-related behaviors, with Per1 promoting Per2 expression and Per2 inhibiting Per1, contributing to depression and bipolar disorder pathophysiology.

This study examines how individual light history affects circadian phase shifts in response to increased light exposure in the Antarctic summer.

This study shows that the circadian clock gene bmal1 is necessary for circatidal rhythms in Eurydice pulchra, while other negative regulators are not.