Circadian rhythm and melatonin

Computational modeling establishes mechanotransduction as a potent modulatory cue for the mammalian circadian clock

This study develops a computational model showing mechanotransduction modulates the mammalian circadian clock by affecting YAP/TAZ and MRTF nuclear translocation, with implications for disease states.

Circadian gene Bmal1 in the lateral habenula regulates alcohol drinking behavior in a sex specific manner

This study shows that Bmal1 in the lateral habenula regulates alcohol drinking behavior differently in male and female mice, with males showing increased intake and females showing reduced intake under aversive conditions.

Light and dopamine impact two circadian neurons to promote morning wakefulness

The paper identifies two circadian neurons in Drosophila that are influenced by light and dopamine to promote morning wakefulness.

Rhythmidia: a modern tool for circadian period analysis of filamentous fungi

Rhythmidia is a Python-based GUI tool for analyzing circadian periods and growth rates in Neurospora crassa race tube experiments, offering efficient and accurate results.

Collective flow of circadian clock information in honeybee colonies

The paper tracks honeybee colony activity over time and shows that mechanical interactions transfer circadian information, leading to synchronized collective behavior.

Feeding status modulates diel vertical migration ofzooplankton via effects on circadian rhythms

This study shows that feeding status affects diel vertical migration of zooplankton by altering circadian rhythms, using high-resolution tracking of copepods.

The rhythmic transcriptional landscape in Caenorhabditis elegans: daily, circadian and novel 16-hour cycling gene expression revealed by RNA-sequencing

This study identifies daily and 16-hour gene expression rhythms in C. elegans using RNA-seq, revealing both circadian and novel oscillatory patterns.

Dopamine enhances GABAA receptor-mediated current amplitude in a subset of intrinsically photosensitive retinal ganglion cells

The paper investigates how dopamine affects GABAergic synaptic currents in intrinsically photosensitive retinal ganglion cells, finding that D1R activation enhances GABA current amplitude via a cAMP/PKA pathway.

EPILEPTOGENESIS INHIBITS THE CIRCADIAN CLOCK AND RESHAPES THE DIURNAL TRANSCRIPTOMIC RHYTHMICITY IN THE MOUSE HIPPOCAMPUS

This study shows that epileptogenesis disrupts the circadian clock and alters diurnal transcriptomic rhythms in the mouse hippocampus, with implications for human epilepsy.

Model integration of circadian and sleep-wake driven contributions to rhythmic gene expression reveals novel regulatory principles

The paper develops a model to integrate circadian and sleep-wake influences on gene expression, revealing tissue-specific regulatory effects and desynchronization after sleep deprivation.

Rhythmic variation in proteomics: challenges and opportunities for statistical power and biomarker identification

This paper shows that time-of-day variation in proteomics increases Type II errors and recommends accounting for rhythmicity in study design to improve statistical power and reproducibility.

Inactivation of the DREAM complex mimics the molecular benefits of sleep.

This study identifies the DREAM complex as a mediator of sleep and circadian benefits, showing that inhibiting DREAM can mimic sleep's cellular repair effects in sleep-deprived organisms.

Altered circadian rhythm, sleep, and rhodopsin 7-dependent shade preference during diapause in Drosophila melanogaster

This study shows that cool temperatures induce deep sleep and alter circadian rhythms in Drosophila melanogaster during diapause, with sleep overriding light-aversion behaviors.

BMAL1 represses transposable elements independently of CLOCK in pluripotent cells

This study shows BMAL1 represses transposable elements in pluripotent cells independently of CLOCK, leading to genome-wide changes and totipotency features when BMAL1 is deleted.

Single-cell variations of circadian clock and immune gene expression in microglia and neurodegeneration

The paper examines circadian gene expression in microglia across health and Huntington's disease, finding disrupted rhythms in symptomatic mice.

Altered Metabolism During the Dark Period in Drosophila Short Sleep Mutants

This study examines metabolic changes in Drosophila short sleep mutants during the dark period, revealing altered metabolite levels and rhythmicity patterns compared to wild type.

Obscured Complexity: How External Cycles Simplify the Dynamics of the Endogenous Circadian Oscillator--take the time series of body temperature records as an example

This study uses a mathematical model to simulate circadian rhythms and shows how external cycles affect the complexity and resetting behavior of the endogenous clock.

Extensive Soma-Soma Plate-Like Contact Sites (Ephapses) Connect Suprachiasmatic Nucleus Neurons

The paper identifies extensive soma-soma plate-like contacts (ephapses) between SCN neurons that may enable synchronization without chemical or electrical synapses.

Clock-dependent chromatin accessibility rhythms regulate circadian transcription

This study shows that chromatin accessibility oscillates with the circadian cycle in Drosophila clock neurons, with distinct motifs associated with dusk and dawn accessibility, and that Period protein is essential for these rhythms.

Circadian clock neurons use activity-regulated gene expression for structural plasticity

The paper shows that activity-regulated genes like Hr38 and Sr control structural plasticity in Drosophila s-LNv circadian neurons by regulating sif transcription.

Bone marrow by day, lymph nodes by night: Undernutrition imparts a distinct circadian rhythm to T cells in mice

This study shows undernutrition disrupts T cell circadian migration in mice, increasing bone marrow residency and reducing lymph node migration during the light phase.

STGram: Non-Invasive Visualization and Analysis of Circadian Rhythms Through Surface Temperature Monitoring

This study uses surface temperature monitoring to visualize and analyze circadian rhythms in adults with jet lag and infants, showing circadian shifts and developmental progression.

PowerCHORD: constructing optimal experimental designs for biological rhythm discovery

PowerCHORD improves biological rhythm detection by optimizing measurement schedules to enhance statistical power for circadian, circalunar, and circannual rhythms.

FlyBox: A Flexible Open-Source Behavior Monitoring System

The paper introduces FlyBox, an open-source behavior monitoring system for Drosophila that is affordable and customizable, along with FlyBoxScanner software for activity monitoring.

Knockout of cryptochrome 1 disrupts circadian rhythm and photoperiodic diapause induction in the silkworm, Bombyx mori

This study shows that knocking out cryptochrome 1 in silkworms disrupts circadian rhythms and photoperiodic diapause induction, highlighting its role as a photoreceptor in the circadian clock.

ninna nanna links circadian and homeostatic sleep drive in Drosophila

This paper identifies the ninna nanna gene in Drosophila, showing it encodes two isoforms that integrate circadian and homeostatic sleep regulation through interconnected neurons.

Quantifying Differential Rhythmicity based on Effect Sizes with LimoRhyde2

The paper extends LimoRhyde2 to analyze differential rhythmicity by estimating effect sizes between conditions, improving biological interpretation in circadian systems biology.

tauFisher accurately predicts circadian time from a single sample of bulk and single-cell transcriptomic data

tauFisher predicts circadian time from bulk and single-cell transcriptomic data by analyzing rhythmic gene correlations, showing strong performance across multiple tissues and experimental settings.

Reorganisation of circadian activity and the pacemaker circuit under novel light regimes

This study investigates how novel light regimes affect circadian activity waveforms in Drosophila, showing dim scotopic illumination induces activity bifurcation and reveals conserved circadian circuit reorganisation.

Flp-recombinase mouse line for genetic manipulation of ipRGCs

This paper describes the generation of a mouse line (Opn4FlpO) that expresses Flp-recombinase specifically in ipRGCs, enabling targeted genetic manipulation of these cells.